公开(公告)号：US20080292052A1

公开(公告)日：2008-11-27

申请号：US11884158

申请日：2006-02-10

申请人： F. Avraham Dilmanian ,  David J. Anchel ,  Glenn Gaudette ,  Pantaleo Romanelli ,  James Hainfeld

发明人： F. Avraham Dilmanian ,  David J. Anchel ,  Glenn Gaudette ,  Pantaleo Romanelli ,  James Hainfeld

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

摘要翻译： 辅助恢复中枢神经系统（CNS）的损伤部位或治疗疾病的方法包括通过平行微平面光束阵列向目标体积提供治疗剂量的X射线辐射。 治疗CNS损伤的剂量暂时从照射部位移除再生抑制剂。 在梁之间存活的基本未照射的细胞迁移到入射梁部分并辅助恢复。 剂量可以使用角度可变的相交微束阵列（AVIMA）在会话上以分数交错。 通过改变梁的取向来施加额外的剂量。 通过将干细胞注射到损伤部位来增强该方法。 应用一个阵列或AVIMA方法来消融与疾病相关的目标体内的选择的细胞用于姑息治疗或治疗效果。 通过照射心房壁来破坏心肌细胞，同时持续旋转受试者来治疗房颤。

公开(公告)号：US07746979B2

公开(公告)日：2010-06-29

申请号：US11884158

申请日：2006-02-10

申请人： F. Avraham Dilmanian ,  David J. Anchel ,  Glenn Gaudette ,  Pantaleo Romanelli ,  James Hainfeld

发明人： F. Avraham Dilmanian ,  David J. Anchel ,  Glenn Gaudette ,  Pantaleo Romanelli ,  James Hainfeld

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/1064 ,  A61N2005/1091

摘要： A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

摘要翻译： 辅助恢复中枢神经系统（CNS）的损伤部位或治疗疾病的方法包括通过平行微平面光束阵列向目标体积提供治疗剂量的X射线辐射。 治疗CNS损伤的剂量暂时从照射部位移除再生抑制剂。 在梁之间存活的基本未照射的细胞迁移到入射梁部分并辅助恢复。 剂量可以使用角度可变的相交微束阵列（AVIMA）在会话上以分数交错。 通过改变梁的取向来施加额外的剂量。 通过将干细胞注射到损伤部位来增强该方法。 应用一个阵列或AVIMA方法来消融与疾病相关的目标体内的选择的细胞用于姑息治疗或治疗效果。 通过照射心房壁来破坏心肌细胞，同时持续旋转受试者来治疗房颤。

公开(公告)号：US20140194944A1

公开(公告)日：2014-07-10

申请号：US14111172

申请日：2012-04-17

申请人： Pantaleo Romanelli ,  Fabio Sebastiano ,  Antonino Paris ,  Stefano Marchetti ,  Paolo Cristiani

发明人： Pantaleo Romanelli ,  Fabio Sebastiano ,  Antonino Paris ,  Stefano Marchetti ,  Paolo Cristiani

IPC分类号： A61N1/36

CPC分类号： A61N1/36064 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/6868 ,  A61N1/0476 ,  A61N1/0529 ,  A61N1/0531

摘要： An implantable device for the acquisition and monitoring of brain bioelectric signals is described. The implantable device has a plurality of active electrodes configured to detect brain bioelectric signals, the active electrodes being arranged on a grid connected to an electronic module of the implantable device according to a predefined pattern. The active electrodes are connected to a microprocessor of the electronic module through respective paths formed on the grid and connected to at least one analog input unit arranged in the electronic module, the at least one analog input unit being in turn connected to at least one passive electrode and to the microprocessor through a data bus. The at least one analog input unit has an analog-to-digital converter for each active electrode connected thereto. A data acquisition and processing system, which includes the implantable device is also described.

摘要翻译： 描述了用于获取和监测大脑生物电信号的可植入装置。 可植入装置具有配置成检测大脑生物电信号的多个有效电极，有源电极根据预定图案被布置在与可植入装置的电子模块连接的格栅上。 有源电极通过形成在电网上的相应路径连接到电子模块的微处理器，并连接到布置在电子模块中的至少一个模拟输入单元，所述至少一个模拟输入单元依次连接至至少一个被动 电极和通过数据总线的微处理器。 所述至少一个模拟输入单元具有用于连接到其上的每个有源电极的模拟 - 数字转换器。 还描述了包括可植入装置的数据采集和处理系统。