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公开(公告)号：US5339347A
公开(公告)日：1994-08-16
申请号：US52927
申请日：1993-04-27
CPC分类号： A61N5/1084 , A61B90/10 , A61N2005/1091 , A61N5/1064
摘要： A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.
摘要翻译： 一种对患者进行放射治疗的方法，包括将目标物（通常为肿瘤）暴露于治疗剂量的高能量电磁辐射（优选X射线辐射），其形式为至少两个非重叠的微束辐射束 具有小于约1毫米宽度的微束。 暴露于微束的靶组织在暴露期间接受辐射剂量，超过这种组织可以存活的最大剂量。 微束之间的非目标组织接受低于可由组织存活的阈值量的辐射的剂量，从而允许非目标组织再生。 微束可以从一个方向或多于一个方向引导靶，在这种情况下，微束在靶组织内重叠，从而增强照射的致死作用，同时保护周围的健康组织。
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公开(公告)号：US4864594A
公开(公告)日：1989-09-05
申请号：US78896
申请日：1987-07-29
申请人： Dan Inbar , F. Avraham Dilmanian , Gideon Berlad
发明人： Dan Inbar , F. Avraham Dilmanian , Gideon Berlad
CPC分类号： A61B6/505 , A61B6/037 , A61B6/4007 , A61B6/482 , G01T1/161 , G01T1/1642
摘要： In-vivo bone density measuring system using a modified emission computed tomographic gamma camera arrangement for detecting radiation from two separate sources located outside of the body of the patient and oppositely disposed to the gamma camera during rotation of the gamma camera and sources means about the patient for obtaining tomographic data. The two separate sources emitting at least two energy levels. The system includes processing means for the detected radiation to provide a bone mineral density map.
摘要翻译： 使用改进的发射计算机断层摄影伽马照相机装置的体内骨密度测量系统，用于检测来自位于患者身体外侧的两个单独源的辐射，并且在伽马照相机和源的旋转期间相对地设置于伽马照相机 用于获取断层摄影数据。 两个独立的光源发射至少两个能级。 该系统包括用于检测的辐射的提供骨矿物质密度图的处理装置。
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3.发明申请公开(公告)号：US20090093863A1
公开(公告)日：2009-04-09
申请号：US11867233
申请日：2007-10-04
申请人： F. Avraham Dilmanian
发明人： F. Avraham Dilmanian
CPC分类号： A61N5/1084 , A61N2005/1091 , G21K1/046
摘要： A radiation delivery system generally includes either a synchrotron source or a support frame and a plurality of microbeam delivery devices supported on the support frame, both to deliver a beam in a hemispherical arrangement. Each of the microbeam delivery devices or synchrotron irradiation ports is adapted to deliver at least one microbeam of radiation along a microbeam delivery axis, wherein the microbeam delivery axes of the plurality of microbeam delivery devices cross within a common target volume.
摘要翻译： 辐射传送系统通常包括同步加速器源或支撑框架以及支撑在支撑框架上的多个微束输送装置，以便以半球形布置的方式输送光束。 每个微束输送装置或同步加速器照射端口适于沿着微束输送轴递送至少一束辐射，其中多个微束输送装置的微束输送轴线在共同目标体积内交叉。
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4.发明申请Methods for Assisting Recovery of Damaged Brain and Spinal Cord and Treating Various Diseases Using Arrays of X-Ray Microplanar Beams 有权使用X射线微平面光束阵列辅助损伤脑脊髓的恢复和治疗各种疾病的方法公开(公告)号：US20080292052A1
公开(公告)日：2008-11-27
申请号：US11884158
申请日：2006-02-10
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/1064 , A61N2005/1091
摘要： A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.
摘要翻译： 辅助恢复中枢神经系统（CNS）的损伤部位或治疗疾病的方法包括通过平行微平面光束阵列向目标体积提供治疗剂量的X射线辐射。 治疗CNS损伤的剂量暂时从照射部位移除再生抑制剂。 在梁之间存活的基本未照射的细胞迁移到入射梁部分并辅助恢复。 剂量可以使用角度可变的相交微束阵列（AVIMA）在会话上以分数交错。 通过改变梁的取向来施加额外的剂量。 通过将干细胞注射到损伤部位来增强该方法。 应用一个阵列或AVIMA方法来消融与疾病相关的目标体内的选择的细胞用于姑息治疗或治疗效果。 通过照射心房壁来破坏心肌细胞，同时持续旋转受试者来治疗房颤。
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公开(公告)号：US20080192892A1
公开(公告)日：2008-08-14
申请号：US11884179
申请日：2006-02-10
IPC分类号： A61N5/10
CPC分类号： A61N5/1045 , A61N2005/109 , A61N2005/1091 , A61N2005/1098
摘要： A method of performing microbeam radiation therapy (MRT) includes delivering a dose only to selected tissue in a target volume (10) with continuous broad beam, first, by interleaving arrays of microplanar beams (30,36) only at the target (10). Administered contrast agents can supplement the effect by preferentially increasing the target dose relative to dose in normal tissue. A broad beam effect is alternatively created using non-interleaving microbeam array(s) with scattering agents administered to selected tissue that preferentially increase valley dose (69) within target to approximate broad beam. The methods of interleaving microbeams are also applied to treat diseases and conditions by ablating at least a portion of selected tissue, or by damaging blood-brain barrier for efficient drug and/or cell administration. A system for performing interlaced microbeam radiosurgery preferably includes two orthogonal radiation source arms (102) for producing and interleaving microbeam arrays (30,36) at the target volume (10). The methods treat tumors, pain, epilepsy, and neurological diseases.
摘要翻译： 一种执行微束放射治疗（MRT）的方法包括：只向具有连续宽束的目标体积（10）中的选定组织递送剂量，首先，仅通过在目标（10）上交错微平面波束阵列（30,36） 。 施用的造影剂可以通过相对于正常组织中的剂量优先增加目标剂量来补充该作用。 交替地使用非交错微束阵列产生广泛的束效应，其具有施用于选定组织的散射剂，其优先地增加靶内的谷剂量（69）以接近宽束。 交织微束束的方法也适用于通过消融选定组织的至少一部分，或通过损害血脑屏障以有效的药物和/或细胞给药来治疗疾病和病症。 用于执行交织微束放射外科的系统优选地包括用于在目标体积（10）处产生和交织微束阵列（30,36）的两个正交辐射源臂（102）。 该方法治疗肿瘤，疼痛，癫痫和神经系统疾病。
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6.发明授权公开(公告)号：US10021087B2
公开(公告)日：2018-07-10
申请号：US14837144
申请日：2015-08-27
IPC分类号： H04L29/06 , H04W12/06 , G06F21/60 , G06F21/62 , G06F21/34 , G16H10/60 , H04W12/08 , H04W4/80
CPC分类号： H04L63/0823 , G06F21/34 , G06F21/606 , G06F21/6245 , G16H10/60 , H04L63/102 , H04W4/80 , H04W12/003 , H04W12/06 , H04W12/08
摘要： A system and method for communicating secure, privatized data stored on a first user device with a second user device requesting access thereto includes initiating a timed access gate for receiving verification of authenticating credentials from the second user device, after the first user credentials associated with the first user device are verified. If the second user device is verified within the predetermined period of time, an authentication handshake between the first user device and the second user device is completed. On completion of the handshake, a communication channel is opened for transmitting the first user's privatized data between the first user device and the second user device.
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公开(公告)号：US20170128739A1
公开(公告)日：2017-05-11
申请号：US15318581
申请日：2015-06-24
申请人： F. Avraham Dilmanian , Sunil KRISHNAN , John ELEY , Board of Regents, The University of Texas System
发明人： F. Avraham DILMANIAN , Sunil KRISHNAN , John ELEY
CPC分类号： A61N5/06 , A61N5/1045 , A61N5/1084 , A61N2005/1087
摘要： A method for delivering therapeutic light ion radiation to a target volume of a subject, wherein the target volume is located at a predetermined depth from the skin, includes irradiating a surface of the skin with an array of light ion minibeams comprising parallel, spatially distinct minibeams at the surface in an amount and spatially arranged and sized to maintain a tissue-sparing effect from the skin to a proximal side of the target volume, and to merge into a solid beam at a proximal side of the target volume. A gap between the parallel, spatially distinct minibeams at the surface and a species of light ions forming the minibeams are selected such that the array merges into a solid beam at a predetermined beam energy, and across all energies for Bragg-peak spreading, at a proximal side of the target volume.
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公开(公告)号：US20100187446A1
公开(公告)日：2010-07-29
申请号：US12692216
申请日：2010-01-22
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095
摘要： A method for delivering therapeutic heavy ion radiation to a subject, wherein a therapeutic dose of heavy ions is delivered substantially only to a target volume within the subject by generating a broad field of radiation effect substantially only within the target volume, and wherein the broad field of radiation effect is not generated in non-targeted tissue. The method includes the step of irradiating the target volume with at least two arrays of heavy ion microbeams, wherein the at least two arrays each have at least two parallel, spatially distinct heavy ion microbeams. The two arrays of microbeams are interleaved substantially only within the target volume to form a substantially continuous broad beam of radiation substantially only within the target volume.
摘要翻译： 一种用于将治疗性重离子辐射递送到受试者的方法，其中通过基本上仅在所述目标体积内产生广泛的辐射效应，其中治疗剂量的重离子基本上仅输送到受试者内的目标体积，并且其中所述宽场 在非目标组织中不产生辐射效应。 该方法包括用至少两个重离子微束阵列照射目标体积的步骤，其中至少两个阵列各自具有至少两个平行的空间上不同的重离子微束。 微阵列的两个阵列基本上仅在目标体积内交错以形成基本上仅在目标体积内的基本上连续的宽的辐射束。
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9.发明授权公开(公告)号：US07661146B2
公开(公告)日：2010-02-09
申请号：US11173133
申请日：2005-07-01
CPC分类号： H04L9/3271 , G06F19/00 , G06F19/328 , G06F21/604 , G06F21/6227 , G06F21/6245 , G06F2221/2141 , G06F2221/2153 , G16H10/65 , H04L9/3231 , H04L9/3263 , H04L9/3297 , H04L2209/88
摘要： A system and method for providing, managing, and accessing a multi-user secure portable database using secure memory cards is provided. The database has a secure portion for storing security keys and a non-secure portion for encrypted data files. Access to the encrypted data files is controlled by assigning access rights through an access control matrix to each encrypted data file according to a hierarchical structure of users. A user requesting access is identified in the hierarchy, associated with a key for allowing the requested access, and the requested access allowed to a file in accordance with the rights allocated through the access control matrix. A patient can selectively grant access to encrypted medical records on his card to a physician. Authentication of the owner/patient is preferably required. Other records required by emergency medical personnel are readable from the same card without requiring permission from the patient.
摘要翻译： 提供了一种使用安全存储卡提供，管理和访问多用户安全便携式数据库的系统和方法。 数据库具有用于存储安全密钥的安全部分和用于加密的数据文件的非安全部分。 根据用户的层次结构，通过访问控制矩阵向每个加密数据文件分配访问权限来控制对加密数据文件的访问。 在层次结构中识别与用于允许所请求的访问的密钥相关联的请求访问的用户，以及根据通过访问控制矩阵分配的权限允许的所请求的访问文件。 患者可以选择性地向医师授予他卡上的加密医疗记录的访问权限。 所有者/患者的认证最好是需要的。 紧急医务人员所需的其他记录可从同一张卡片中读取，无需患者许可。
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10.发明申请METHOD AND SYSTEM FOR PROVIDING A SECURE COMMUNICATION CHANNEL TO PORTABLE PRIVATIZED DATA 审中-公开提供安全通信信道到便携式私有数据的方法和系统公开(公告)号：US20160080364A1
公开(公告)日：2016-03-17
申请号：US14837144
申请日：2015-08-27
CPC分类号： H04L63/0823 , G06F19/00 , G06F21/34 , G06F21/606 , G06F21/6245 , G16H10/60 , H04L63/102 , H04W4/80 , H04W12/06 , H04W12/08
摘要： A system and method for communicating secure, privatized data stored on a first user device with a second user device requesting access thereto includes initiating a timed access gate for receiving verification of authenticating credentials from the second user device, after the first user credentials associated with the first user device are verified. If the second user device is verified within the predetermined period of time, an authentication handshake between the first user device and the second user device is completed. On completion of the handshake, a communication channel is opened for transmitting the first user's privatized data between the first user device and the second user device.
摘要翻译： 用于将存储在第一用户设备上的安全私有化数据与请求访问的第二用户设备通信的系统和方法包括在与所述第二用户认证相关联的所述第一用户凭证之后启动用于接收来自所述第二用户设备的认证凭证的验证的定时访问门 第一个用户设备被验证。 如果在预定时间段内验证第二用户设备，则完成第一用户设备和第二用户设备之间的认证握手。 在握手完成时，打开通信通道，用于在第一用户设备和第二用户设备之间发送第一用户的私有化数据。
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