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公开(公告)号:US10787505B2
公开(公告)日:2020-09-29
申请号:US15035602
申请日:2014-11-13
申请人: F. HOFFMAN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
摘要: The present invention relates to an oligopeptide and conjugates thereof. The present invention also relates to the use of these oligopeptide conjugates for treating or diagnosing disorders mediated by amyloid β deposits. Finally, the present invention also relates to a coupling method for obtaining oligopeptide coupled with a substance of interest (functional conjugates).
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公开(公告)号:US11124563B2
公开(公告)日:2021-09-21
申请号:US16700788
申请日:2019-12-02
申请人: F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
摘要: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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公开(公告)号:US10538582B2
公开(公告)日:2020-01-21
申请号:US16141914
申请日:2018-09-25
申请人: F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
摘要: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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4.
公开(公告)号:US20190077853A1
公开(公告)日:2019-03-14
申请号:US16141914
申请日:2018-09-25
申请人: F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
CPC分类号: C07K16/18 , A61K49/0041 , A61K49/0058 , A61K49/16 , A61K51/10 , C07K2317/22 , C07K2317/34 , C07K2317/569 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821
摘要: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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公开(公告)号:US10087245B2
公开(公告)日:2018-10-02
申请号:US15114324
申请日:2015-01-28
申请人: F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
摘要: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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公开(公告)号:US09738712B2
公开(公告)日:2017-08-22
申请号:US15035582
申请日:2014-11-13
申请人: F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人: Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
IPC分类号: C07K16/18 , G01N33/68 , A61K49/16 , C07H21/04 , A61K47/48 , A61K51/10 , A61K49/00 , A61K49/10 , A61K39/00
CPC分类号: C07K16/18 , A61K47/6803 , A61K47/6843 , A61K49/0058 , A61K49/108 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/22 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387 , G01N2800/52
摘要: The present invention relates to variable domain of a camelid heavy-chain antibodies directed to amyloid β and conjugates thereof. The present invention also relates to the use of these antibody conjugates for treating or diagnosing disorders mediated by amyloid β deposits.
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