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1.发明申请公开(公告)号：US20200165329A1
公开(公告)日：2020-05-28
申请号：US16700788
申请日：2019-12-02
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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2.发明申请CAMELID SINGLE-DOMAIN ANTIBODY DIRECTED AGAINST AMYLOID BETA AND METHODS FOR PRODUCING CONJUGATES THEREOF 有权针对AMYLOID BETA的CAMELID单抗体抗体及其生产方法公开(公告)号：US20160347831A1
公开(公告)日：2016-12-01
申请号：US15035582
申请日：2014-11-13
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6843 , A61K49/0058 , A61K49/108 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/22 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387 , G01N2800/52
摘要： The present invention relates to variable domain of a camelid heavy-chain antibodies directed to amyloid β and conjugates thereof. The present invention also relates to the use of these antibody conjugates for treating or diagnosing disorders mediated by amyloid β deposits.
摘要翻译： 本发明涉及针对淀粉样蛋白β的骆驼重链抗体及其缀合物的可变结构域。 本发明还涉及这些抗体缀合物用于治疗或诊断由淀粉样蛋白β沉积物介导的病症的用途。
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公开(公告)号：US20160355575A1
公开(公告)日：2016-12-08
申请号：US15035602
申请日：2014-11-13
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
摘要： The present invention relates to an oligopeptide and conjugates thereof. The present invention also relates to the use of these oligopeptide conjugates for treating or diagnosing disorders mediated by amyloid β deposits. Finally, the present invention also relates to a coupling method for obtaining oligopeptide coupled with a substance of interest (functional conjugates).
摘要翻译： 本发明涉及寡肽及其缀合物。 本发明还涉及这些寡肽缀合物用于治疗或诊断由淀粉样蛋白β沉积物介导的病症的用途。 最后，本发明还涉及用于获得与感兴趣物质（功能性共轭物）偶联的寡肽的偶联方法。
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4.发明申请CAMELID SINGLE-DOMAIN ANTIBODY DIRECTED AGAINST PHOSPHORYLATED TAU PROTEINS AND METHODS FOR PRODUCING CONJUGATES THEREOF 审中-公开针对磷酸化TAU蛋白的CAMELID单抗体抗体及其生产方法公开(公告)号：US20170058022A1
公开(公告)日：2017-03-02
申请号：US15114324
申请日：2015-01-28
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES AL TERNATIVES , CENTRE NATION DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
CPC分类号： C07K16/18 , A61K49/0041 , A61K49/0058 , A61K49/16 , A61K51/10 , C07K2317/22 , C07K2317/34 , C07K2317/569 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
摘要翻译： 本发明涉及针对磷酸化tau蛋白及其缀合物的骆驼重链抗体的可变结构域。 本发明还涉及这些结构域或缀合物用于治疗或诊断由神经原纤维缠结，神经纤维丝或营养不良神经突诸如tau蛋白病介导的病症的用途。
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