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公开(公告)号：US20200056210A1
公开(公告)日：2020-02-20
申请号：US16610053
申请日：2018-04-27
Applicant: Firmenich SA
Inventor： Pan Li , Qi Wang , Xiu-Feng He , Olivier Haefliger
Abstract: Described herein is a method of producing drimenol and/or drimenol derivatives, the method including contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.
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公开(公告)号：US11124807B2
公开(公告)日：2021-09-21
申请号：US16610053
申请日：2018-04-27
Applicant: Firmenich SA
Inventor： Pan Li , Qi Wang , Xiu-Feng He , Olivier Haefliger
Abstract: Described herein is a method of producing drimenol and/or drimenol derivatives, the method including contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.
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公开(公告)号：US20210254039A1
公开(公告)日：2021-08-19
申请号：US17059071
申请日：2019-05-28
Applicant: FIRMENICH SA
Inventor： Didier Belorgey , Xiu-Feng He , Qi Wang , Lily Ji-Xiu Zhang
Abstract: Described herein is a method of producing a drimane sesquiterpene, such as an albicanol compound and/or derivatives thereof, by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide of the Haloacid dehalogenase-like (HAD-like) hydrolase superfamily as obtainable from plants of the genus Dryopteris, in particular of the species Dryopteris fragrans. The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as an albicanol compound.
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公开(公告)号：US11874272B2
公开(公告)日：2024-01-16
申请号：US16757983
申请日：2019-01-09
Applicant: FIRMENICH SA
Inventor： Xiu-Feng He , Lily Ji-Xiu Zhang
CPC classification number: G01N33/50 , G01N1/405 , G01N30/06 , G01N30/7206 , G01N33/497 , G01N2001/4061 , G01N2030/025 , G01N2030/128 , G01N2033/4975
Abstract: The present disclosure related to a method for screening compounds having the ability to prevent, treat or reduce malodor development on body surfaces. In particular, the method screens for compounds having the ability of preventing sweat malodor development caused by malodor causing volatile acid compounds and/or malodor causing volatile sulphur compounds. The present disclosure is based on a sensitive analytical method to determine the presence of the precursors of malodor causing volatile acid compounds and/or malodor causing volatile sulphur compounds present in sweat, which are metabolised by bacteria, such as, for example, Cornebacteria or Staphylococci to malodor causing volatile acid compounds and malodor causing volatile sulphur compounds.
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公开(公告)号：US20210395786A1
公开(公告)日：2021-12-23
申请号：US17407892
申请日：2021-08-20
Applicant: Firmenich SA
Inventor： Pan Li , Qi Wang , Xiu-Feng He , Olivier Haefliger
Abstract: The present application relates to a method of producing drimenol and/or drimenol derivatives by comprising contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also provided are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.
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Patent Agency Ranking
公开(公告)号：US11773414B2
公开(公告)日：2023-10-03
申请号：US17407892
申请日：2021-08-20
Applicant: Firmenich SA
Inventor： Pan Li , Qi Wang , Xiu-Feng He , Olivier Haefliger
CPC classification number: C12P7/02 , C12N9/88 , C12P5/007 , C12Y402/03126
Abstract: The present application relates to a method of producing drimenol and/or drimenol derivatives by comprising contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also provided are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.
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公开(公告)号：US11345907B2
公开(公告)日：2022-05-31
申请号：US17059071
申请日：2019-05-28
Applicant: FIRMENICH SA
Inventor： Didier Belorgey , Xiu-Feng He , Qi Wang , Lily Ji-Xiu Zhang
Abstract: Described herein is a method of producing a drimane sesquiterpene, such as an albicanol compound and/or derivatives thereof, by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide of the Haloacid dehalogenase-like (HAD-like) hydrolase superfamily as obtainable from plants of the genus Dryopteris, in particular of the species Dryopteris fragrans. The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as an albicanol compound.
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公开(公告)号：US10550409B2
公开(公告)日：2020-02-04
申请号：US15772567
申请日：2016-11-07
Applicant: Firmenich SA
Inventor： Eric Wen-Bo Liu , Xiu-Feng He , Olivier Haefliger , Zong-Xia Yu , Pan Li
IPC: C12P7/02
Abstract: The present invention discloses a method of producing drimenol and/or drimenol derivatives by contacting a polypeptide with farnesyl pyrophosphate. Also provided is an amino acid sequence of a polypeptide useful in the methods of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.
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公开(公告)号：US20210386103A1
公开(公告)日：2021-12-16
申请号：US17420517
申请日：2020-04-23
Applicant: FIRMENICH SA
Inventor： Xiu-Feng He , Christian Starkenmann , Christoph Cerny , Yi-Min Wang
Abstract: Described herein are an extract from lettuce (Lactuca sativa), in particular of stalk lettuce (Lactuca sativa var. angustana), including 2-acetyl-1-pyrroline and, optionally, precursors of 2-acetyl-1-pyrroline as well as flavoring compositions including such an extract and a method for the preparation of such an extract. Also described herein are the use of such an extract as a taste or flavor ingredient in a consumer product and a method of enhancing, improving, modifying the taste or flavor of a consumer product by making use of such an extract.
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公开(公告)号：US20200340975A1
公开(公告)日：2020-10-29
申请号：US16757983
申请日：2019-01-09
Applicant: FIRMENICH SA
Inventor： Xiu-Feng He , Lily Ji-Xiu Zhang
IPC: G01N33/50 , G01N33/497 , G01N1/40 , G01N30/06 , G01N30/72
Abstract: The present disclosure related to a method for screening compounds having the ability to prevent, treat or reduce malodor development on body surfaces. In particular, the method screens for compounds having the ability of preventing sweat malodor development caused by malodor causing volatile acid compounds and/or malodor causing volatile sulphur compounds. The present disclosure is based on a sensitive analytical method to determine the presence of the precursors of malodor causing volatile acid compounds and/or malodor causing volatile sulphur compounds present in sweat, which are metabolised by bacteria, such as, for example, Cornebacteria or Staphylococci to malodor causing volatile acid compounds and malodor causing volatile sulphur compounds.
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