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1.发明公开公开(公告)号：US20230192870A1
公开(公告)日：2023-06-22
申请号：US17812592
申请日：2022-07-14
发明人： Katherine E. Lewis , Serena Kimi Perna , Michael Carleton , Ke Xu , Penny Phillips , Dimple Pandya , Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Janine Powers , Ernestine Lee
IPC分类号： C07K16/28 , A61K47/69 , A61K47/64 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/395 , C12Q1/6886
CPC分类号： C07K16/2866 , A61K47/6929 , A61K47/643 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/3955 , C07K16/2818 , C12Q1/6886 , A61K2039/507
摘要： The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
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公开(公告)号：US20220168416A1
公开(公告)日：2022-06-02
申请号：US17554423
申请日：2021-12-17
IPC分类号： A61K39/395 , C07K16/28 , A61K33/243 , A61K31/337 , A61K31/513 , A61K45/06
摘要： The present invention provides antibodies that bind FGFR2IIIb, wherein the antibodies are afucosylated. The present invention provides compositions comprising antibodies that bind FGFR2IIIb, wherein at least 95% of the antibodies in the composition are afucosylated. In some embodiments, methods of treating cancer comprising administering afucosylated anti-FGFR2IIIb antibodies are provided.
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公开(公告)号：US10975153B2
公开(公告)日：2021-04-13
申请号：US15319143
申请日：2015-06-18
发明人： Julie Hambleton , Emma Masteller , James Zanghi , Robert Sikorski , Hong Xiang
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395
摘要： Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis.
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公开(公告)号：US20160152715A1
公开(公告)日：2016-06-02
申请号：US14925534
申请日：2015-10-28
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2803 , C07K16/2818 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
摘要翻译： 提供了与PD-1 / PD-L1抑制剂结合使用结合集落刺激因子1受体（CSF1R）的抗体治疗癌症的方法。
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公开(公告)号：US20150050273A1
公开(公告)日：2015-02-19
申请号：US14447751
申请日：2014-07-31
IPC分类号： C07K16/28
CPC分类号： A61K39/3955 , A61K31/337 , A61K31/513 , A61K33/24 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/92 , A61K2300/00
摘要： The present invention provides antibodies that bind FGFR2IIIb, wherein the antibodies are afucosylated. The present invention provides compositions comprising antibodies that bind FGFR2IIIb, wherein at least 95% of the antibodies in the composition are afucosylated. In some embodiments, methods of treating cancer comprising administering afucosylated anti-FGFR2IIIb antibodies are provided.
摘要翻译： 本发明提供了结合FGFR2IIIb的抗体，其中抗体是非糖基化的。 本发明提供了包含结合FGFR2IIIb的抗体的组合物，其中组合物中至少95％的抗体是非岩藻糖基化的。 在一些实施方案中，提供了治疗癌症的方法，其包括施用非成胶质细胞的抗FGFR2IIIb抗体。
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公开(公告)号：US20230212299A1
公开(公告)日：2023-07-06
申请号：US18069511
申请日：2022-12-21
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
CPC分类号： C07K16/2863 , C07K16/2896 , A61P35/00 , C07K2317/565
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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公开(公告)号：US10730949B2
公开(公告)日：2020-08-04
申请号：US16015371
申请日：2018-06-22
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
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公开(公告)号：US20180094067A1
公开(公告)日：2018-04-05
申请号：US15680664
申请日：2017-08-18
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2803 , C07K16/2818 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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公开(公告)号：US20160185869A1
公开(公告)日：2016-06-30
申请号：US14976346
申请日：2015-12-21
发明人： Robert Sikorski , Julie Hambleton , Neil Sankar
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
摘要翻译： 提供了结合集落刺激因子1受体（CSF1R）的抗体治疗色素沉着绒毛结节滑膜炎（PVNS）的方法。
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公开(公告)号：US11566076B2
公开(公告)日：2023-01-31
申请号：US16808910
申请日：2020-03-04
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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