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1.发明公开公开(公告)号：US20230192870A1
公开(公告)日：2023-06-22
申请号：US17812592
申请日：2022-07-14
发明人： Katherine E. Lewis , Serena Kimi Perna , Michael Carleton , Ke Xu , Penny Phillips , Dimple Pandya , Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Janine Powers , Ernestine Lee
IPC分类号： C07K16/28 , A61K47/69 , A61K47/64 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/395 , C12Q1/6886
CPC分类号： C07K16/2866 , A61K47/6929 , A61K47/643 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/3955 , C07K16/2818 , C12Q1/6886 , A61K2039/507
摘要： The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
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公开(公告)号：US10975153B2
公开(公告)日：2021-04-13
申请号：US15319143
申请日：2015-06-18
发明人： Julie Hambleton , Emma Masteller , James Zanghi , Robert Sikorski , Hong Xiang
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395
摘要： Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis.
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公开(公告)号：US20160152715A1
公开(公告)日：2016-06-02
申请号：US14925534
申请日：2015-10-28
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2803 , C07K16/2818 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
摘要翻译： 提供了与PD-1 / PD-L1抑制剂结合使用结合集落刺激因子1受体（CSF1R）的抗体治疗癌症的方法。
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公开(公告)号：US11566076B2
公开(公告)日：2023-01-31
申请号：US16808910
申请日：2020-03-04
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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公开(公告)号：US11421034B2
公开(公告)日：2022-08-23
申请号：US16646690
申请日：2018-09-12
发明人： Katherine E. Lewis , Serena Kimi Perna , Michael Carleton , Ke Xu , Penny Phillips , Dimple Pandya , Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Janine Powers , Ernestine Lee
IPC分类号： C07K16/28 , A61K47/69 , A61K47/64 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/395 , C12Q1/6886 , A61K39/00
摘要： The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
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公开(公告)号：US20200299392A1
公开(公告)日：2020-09-24
申请号：US16808910
申请日：2020-03-04
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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公开(公告)号：US20190119390A1
公开(公告)日：2019-04-25
申请号：US16015371
申请日：2018-06-22
IPC分类号： C07K16/28
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
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公开(公告)号：US10221244B2
公开(公告)日：2019-03-05
申请号：US15680664
申请日：2017-08-18
发明人： Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Katherine E. Lewis
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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公开(公告)号：US10040858B2
公开(公告)日：2018-08-07
申请号：US14976346
申请日：2015-12-21
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
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公开(公告)号：US20170145103A1
公开(公告)日：2017-05-25
申请号：US15358941
申请日：2016-11-22
发明人： Kristen Pierce , Janine Powers , Servando Palencia , Robert Sikorski , Majid Ghoddusi , Kartik Krishnan
IPC分类号： C07K16/28 , G01N33/574 , G01N33/50 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , A61K2039/507 , A61K2039/55 , C07K16/2818 , C07K16/2896 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K16/3084 , C07K2317/34 , C07K2317/41 , G01N33/5091 , G01N33/57407 , G01N33/57446 , G01N33/57492 , G01N2333/71 , G01N2800/52
摘要： Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of PD-1 or PD-L1. In some embodiments, FGFR2 inhibitors may comprise FGFR2 antibodies or FGFR2 extracellular domain (ECD) polypeptides, or FGFR2 ECD fusion molecules comprising an FGFR2 ECD and a fusion partner. In some embodiments, PD-1/PD-L1 inhibitors may comprise anti-PD-1 antibodies such as antibodies that bind to PD-1 or to PD-L1 and inhibit interactions between these proteins, as well as PD-1 fusion proteins or polypeptides. This application also provides methods of predicting response to treatment of cancer, such as bladder or gastric cancer, with FGFR2 inhibitors by determining FGFR2 overexpression and/or gene amplification in tumor cells of cancer subjects before treatment with FGFR2 inhibitors either alone or in combination with immune stimulating agents.
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