公开(公告)号：US20200253939A1

公开(公告)日：2020-08-13

申请号：US15929436

申请日：2020-05-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Anna Ericsson ,  Neal Green ,  Gary Gustafson ,  David R. Lancia ,  Gary Marshall ,  Lorna Mitchell ,  David Richard ,  Zhongguo Wang

IPC: A61K31/436 ,  A61K9/00 ,  A61P7/06

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

公开(公告)号：US10029995B2

公开(公告)日：2018-07-24

申请号：US15255817

申请日：2016-09-02

Applicant: Forma Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Bingsong Han ,  Nicholas Barczak ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia ,  Kenneth W. Bair

IPC: C07D265/36 ,  C07D413/12 ,  C07D413/06 ,  C07D401/04 ,  C07D279/16 ,  C07D491/107 ,  C07D413/10 ,  C07D471/04 ,  C07D417/06 ,  C07D513/04 ,  C07D487/04 ,  C07D265/34 ,  C07D279/14

Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.