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公开(公告)号:US20120003212A1
公开(公告)日:2012-01-05
申请号:US13030978
申请日:2011-02-18
申请人: FRANK S. WALSH , MARGARET M. ZALESKA , DAVID S. HOWLAND , ERIKA L.F. HOLZBAUR-HOWLAND , LIOUDMILA TCHISTIAKOVA , RIYEZ KARIM , PAMELA KELLEY , XIANG-YANG TAN , SEUNG POON KWAK , KAREN WALLACE , NICHOLAS WEBER , MENELAS N. PANGALOS , WILLIAM KELLEY
发明人: FRANK S. WALSH , MARGARET M. ZALESKA , DAVID S. HOWLAND , ERIKA L.F. HOLZBAUR-HOWLAND , LIOUDMILA TCHISTIAKOVA , RIYEZ KARIM , PAMELA KELLEY , XIANG-YANG TAN , SEUNG POON KWAK , KAREN WALLACE , NICHOLAS WEBER , MENELAS N. PANGALOS , WILLIAM KELLEY
IPC分类号: A61K39/395 , A61P21/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.