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公开(公告)号:US20180009943A1
公开(公告)日:2018-01-11
申请号:US15545272
申请日:2016-01-20
发明人: Donald BROOKS , Jayachandran KIZHAKKEDATHU , Rajesh SHENOI , Marie WEINHART , Benjamin LAI , Rainer HAAG , Dominic GROEGER
IPC分类号: C08G65/334 , A61K31/255 , A61K38/36
CPC分类号: C08G65/3344 , A61K31/255 , A61K38/36 , C08G65/32 , C08G2650/54
摘要: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.
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公开(公告)号:US20230132202A1
公开(公告)日:2023-04-27
申请号:US17793907
申请日:2021-02-19
IPC分类号: C09D133/26 , C09D5/16 , C08L33/26 , C08K3/28 , C09D5/14
摘要: Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.
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公开(公告)号:US20210345601A1
公开(公告)日:2021-11-11
申请号:US17269238
申请日:2019-08-16
发明人: Marcelo CYPEL , Aizhou WANG , Shafique KESHAVJEE , Stephen G. WITHERS , Peter RAHFELD , Jayachandran KIZHAKKEDATHU
摘要: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods, uses, associated therewith. In particular, the perfusion fluids comprise two enzymes, GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore, the compositions described herein were found to have activity at temperatures and pH levels suitable for cell viability.
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公开(公告)号:US20210324361A1
公开(公告)日:2021-10-21
申请号:US17269235
申请日:2019-08-16
摘要: Provided herein are enzymatic compositions for carbohydrate antigen cleavage, methods, uses, apparatuses and systems associated therewith. In particular, the composition comprises two enzymes, GalNAcDeacetylase and Galactosaminidase and the composition may further comprise a crowding agent. Furthermore, the compositions described herein were found to have activity a temperatures and pH levels suitable for cell viability.
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