公开(公告)号：US20190168444A1

公开(公告)日：2019-06-06

申请号：US16213648

申请日：2018-12-07

Applicant: FUJIFILM Corporation

Inventor： Manabu KATSUMURA ,  Takahiro HIRATSUKA ,  Hideo FUSHIMI ,  Yoshio ISHII ,  Ai OKAMURA ,  Hiroshi OTA ,  Jun ARAKAWA

IPC: B29C64/112 ,  B29C64/209 ,  A61L27/22 ,  A61L27/50 ,  B29C64/188

Abstract: An object of the present invention is to provide a method for producing a gelatin formed body having a minimized content of a component harmful to a living body and high biocompatibility with high shaping accuracy, and a gelatin formed body produced by the method. According to the present invention, provided is a method for producing a gelatin formed body, the method including: a step a of forming, on a substrate, a layer containing a powder which is obtained by air-drying an aqueous gelatin solution and has an average particle diameter of 25 to 200 μm; and a step b of jetting liquid droplets of an aqueous solution containing alcohols having a boiling point of 120° C. or lower toward the layer formed in the step a from a nozzle and flying the jetted liquid droplets so that the liquid droplets are landed on the layer formed in the step a, thereby forming a gelatin formed body.

公开(公告)号：US20190167841A1

公开(公告)日：2019-06-06

申请号：US16204987

申请日：2018-11-29

Applicant: FUJIFILM Corporation

Inventor： Hiroshi OTA ,  Manabu KATSUMURA ,  Kazuya KAWASAKI ,  Yoshio ISHII ,  Hideo FUSHIMI ,  Takahiro HIRATSUKA ,  Ai OKAMURA ,  Mamoru NISHITANI ,  Masayuki EZUMI

IPC: A61L27/12 ,  A61L27/22 ,  B28B1/30 ,  B28B1/00

Abstract: Provided are a method for rapidly producing a calcium phosphate molded article having high strength with high shaping precision, a calcium phosphate molded article produced by the method, and a material for transplantation. Disclosed is a method for producing a calcium phosphate molded article, the method including: step (a) of forming a layer containing a calcium phosphate powder having a ratio of the numbers of atoms of Ca/P of 1.4 to 1.8 on a substrate; and step (b) of producing a calcium phosphate molded article by jetting an organic acid solution having a pH of 3.5 or lower and including an organic acid whose calcium salt has a solubility in water of 1 g/100 mL or less, through a nozzle unit into a liquid droplet state, thereby dropping the organic acid solution onto the layer containing a calcium phosphate powder formed in step (a).

公开(公告)号：US20160008508A1

公开(公告)日：2016-01-14

申请号：US14838545

申请日：2015-08-28

Applicant: FUJIFILM CORPORATION

Inventor： Izumi NAKAHARA ,  Hideo FUSHIMI ,  Takahiro HIRATSUKA ,  Ai OKAMURA ,  Shoji OYA ,  Hidekazu SAKAI ,  Yoshitaka OONO

IPC: A61L27/22 ,  A61L27/54 ,  A61L27/56 ,  C07K14/78

CPC classification number: A61L27/222 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/412 ,  A61L2430/02 ,  C07K14/78

Abstract: A tissue repair material includes gelatin granules, and the tissue repair material exhibits a water absorptivity of 800% by mass or more, and a residual ratio of 60% by mass or less after three hours of decomposition treatment using 1 mol/L hydrochloric acid. A block-shaped tissue repair material includes gelatin, and the block-shaped tissue repair material exhibits a water absorptivity of 800% by mass or more, and a residual ratio of 60% by mass or less after three hours of decomposition treatment using 1 mol/L hydrochloric acid.

Abstract translation: 组织修复材料包括明胶颗粒，组织修复材料在使用1mol / L盐酸分解处理3小时后，其吸水率为800质​​量％以上，残留率为60质量％以下。 块形组织修复材料包括明胶，并且块状组织修复材料在3小时的分解处理后，使用1摩尔，表现出800质量％以上的吸水率和60质量％以下的残留率 / L盐酸。

公开(公告)号：US20250058019A1

公开(公告)日：2025-02-20

申请号：US18822673

申请日：2024-09-03

Applicant: FUJIFILM Corporation

Inventor： Sayami ITO ,  Ai OKAMURA

IPC: A61L27/22 ,  A61L27/56

Abstract: A tissue repair material and a manufacturing method of a tissue repair material, in which a crosslinked gelatin is contained in the tissue repair material and in an elution curve of the crosslinked gelatin, which is obtained by gel permeation chromatography under the following conditions, at least one absorption peak with an absorbance of 0.025 or more is present in a molecular weight range of 14 kDa or more and 51 kDa or less.

公开(公告)号：US20170143767A1

公开(公告)日：2017-05-25

申请号：US15425518

申请日：2017-02-06

Applicant: FUJIFILM Corporation

Inventor： Hayato MIYOSHI ,  Ai OKAMURA ,  Ciara C. TATE ,  Monique A. DAO

IPC: A61K35/30 ,  C12N5/0797 ,  C12N5/079 ,  A61K38/39

CPC classification number: A61K35/30 ,  A61K38/39 ,  C12N5/0622 ,  C12N5/0623 ,  C12N2501/01 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2501/385 ,  C12N2501/42 ,  C12N2506/1353 ,  C12N2510/00 ,  C12N2533/54

Abstract: It is an object of the present invention to provide a cell-containing composition capable of suppressing the outflow of the cells after transplantation and improving the survival rate of the cells. The present invention provides a composition which comprises any of bone marrow stromal cell-derived neural precursor cells, bone marrow stromal cell-derived Schwann cells, or bone marrow stromal cell-derived skeletal muscle cells; and a biocompatible polymer.

公开(公告)号：US20150272998A1

公开(公告)日：2015-10-01

申请号：US14739483

申请日：2015-06-15

Applicant: FUJIFILM CORPORATION

Inventor： Hayato MIYOSHI ,  Ai OKAMURA ,  Ciara C. TATE ,  Monique A. DAO

IPC: A61K35/30 ,  A61K38/39

CPC classification number: A61K35/30 ,  A61K38/39 ,  C12N5/0622 ,  C12N5/0623 ,  C12N2501/01 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2501/385 ,  C12N2501/42 ,  C12N2506/1353 ,  C12N2510/00 ,  C12N2533/54

Abstract: It is an object of the present invention to provide a cell-containing composition capable of suppressing the outflow of the cells after transplantation and improving the survival rate of the cells. The present invention provides a composition which comprises any of bone marrow stromal cell-derived neural precursor cells, bone marrow stromal cell-derived Schwann cells, or bone marrow stromal cell-derived skeletal muscle cells; and a biocompatible polymer.

Abstract translation: 本发明的目的是提供一种能够抑制移植后细胞流出并提高细胞存活率的含细胞的组合物。 本发明提供了包含骨髓基质细胞衍生的神经前体细胞，骨髓基质细胞衍生的雪旺烷细胞或骨髓基质细胞衍生的骨骼肌细胞中的任一种的组合物; 和生物相容性聚合物。