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公开(公告)号：US20210174506A1
公开(公告)日：2021-06-10
申请号：US17181651
申请日：2021-02-22
Applicant: FUJIFILM Corporation
Inventor： Sohichiro NAKAMURA , Ryusuke OSAKI , Sho ONOZAWA
Abstract: A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a phase difference amount density by dividing a total phase difference amount that is a value obtained by integrating a phase difference amount of each of a plurality of pixels constituting the phase difference image by a volume of the aggregate, and determining a state of the aggregate on the basis of a time transition of the phase difference amount density.
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公开(公告)号：US20210174507A1
公开(公告)日：2021-06-10
申请号：US17182569
申请日：2021-02-23
Applicant: FUJIFILM Corporation
Inventor： Sohichiro NAKAMURA , Sho ONOZAWA , Ryusuke OSAKI
Abstract: A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a first index value that indicates a randomness of an array of a phase difference amount in a plurality of pixels constituting the phase difference image, and determining a state of the cells constituting the aggregate on the basis of the first index value.
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公开(公告)号：US20230353888A1
公开(公告)日：2023-11-02
申请号：US18348311
申请日：2023-07-06
Applicant: FUJIFILM Corporation
Inventor： Masayuki NAYA , Ryusuke OSAKI , Sohichiro NAKAMURA
CPC classification number: H04N23/95 , H04N23/56 , G02B26/0833
Abstract: Pixels of a mask image with which a target object is irradiated are shifted by a determined distance by sequentially turning on one light emission point or two or more light emission points of a light source with respect to a single mask pattern generated in a spatial modulation element, a pixel shift amount of the mask pattern determined by a position of the light emission point to be turned on of the light source is known, the target object is irradiated with mask images according to a plurality of mask patterns depending on the positions of the light emission point of the light source and the spatial modulation element, and a computer calculates a correlation between a light intensity detected by a detector and the mask image with which the target object is irradiated, to construct an image of the target object. With this, an imaging device and an imaging method capable of achieving an increase in speed of mask pattern irradiation in single-pixel imaging and significantly increasing an input speed of single-pixel imaging are provided.
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Patent Agency Ranking
公开(公告)号：US20240029253A1
公开(公告)日：2024-01-25
申请号：US18479832
申请日：2023-10-03
Applicant: FUJIFILM CORPORATION
Inventor： Takeharu TANI , Ryusuke OSAKI
CPC classification number: G06T7/0012 , G06T7/70 , G06T17/00 , G01N15/1436 , G03H1/0443 , G03H1/0005 , G06T2207/30044 , G01N2015/1454 , G01N2015/0065
Abstract: Provided is a method for acquiring an evaluation value that can suppress an influence caused by an orientation of an object to be evaluated on an evaluation value derived based on a phase image of the object to be evaluated. The method for acquiring an evaluation value includes generating a phase image showing a phase distribution of light transmitted through an object, deriving an evaluation value of the object based on the phase image, and correcting the evaluation value by using a correction coefficient determined in accordance with an orientation of the object in the phase image.
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公开(公告)号：US20240027959A1
公开(公告)日：2024-01-25
申请号：US18476317
申请日：2023-09-28
Applicant: FUJIFILM CORPORATION
Inventor： Hideki YASUDA , Ryusuke OSAKI
CPC classification number: G03H1/02 , G03H1/22 , G06T7/0012 , G06T2207/30024
Abstract: A holography apparatus 10 includes an optical system 200 that forms an interference image due to interference between object light L1 and reference light L2. The optical system 200 includes a retarder 30 that is disposed on an optical path of the object light or the reference light, and a rotation mechanism 31 that rotates the retarder 30 with an optical axis of the object light L1 or the reference light L2 as a rotation axis. The holography apparatus 10 includes an imaging unit 40 that captures the interference image, a control unit 50 that derives an evaluation value for the interference image captured by the imaging unit 40 and controls a rotational position of the rotation mechanism 31 based on the evaluation value.
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公开(公告)号：US20220244243A1
公开(公告)日：2022-08-04
申请号：US17727049
申请日：2022-04-22
Applicant: FUJIFILM Corporation
Inventor： Yuta MURAKAMI , Ryusuke OSAKI , Sho ONOZAWA , Sohichiro NAKAMURA
Abstract: There is provided a method including generating a phase contrast image of an aggregate of a pluripotent stem cell from a hologram in which the aggregate is captured; deriving, based on the phase contrast image, an index value indicating a complexity or simplicity of a contour line, the index value being determined according to a relationship between an area of the aggregate and a length of the contour line of the aggregate; and sorting the pluripotent stem cell based on the index value.
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7.发明申请公开(公告)号：US20220083004A1
公开(公告)日：2022-03-17
申请号：US17537590
申请日：2021-11-30
Applicant: FUJIFILM Corporation
Inventor： Sohichiro NAKAMURA , Sho ONOZAWA , Ryusuke OSAKI
Abstract: An image processing apparatus includes an acquisition unit that acquires a hologram obtained by imaging a plurality of granules contained within an imaging visual field, a generation unit that generates, from the hologram, phase difference images at positions different from each other in an optical axis direction in a case in which the hologram is captured, a specifying unit that specifies a plurality of image ranges in a direction of a plane intersecting the optical axis direction, which correspond to the plurality of granules, in an averaged image obtained by averaging at least some of the phase difference images, and an extraction unit that extracts the phase difference image at a center position of a corresponding granule in the optical axis direction for each of the plurality of image ranges.
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公开(公告)号：US20200342599A1
公开(公告)日：2020-10-29
申请号：US16928974
申请日：2020-07-14
Applicant: FUJIFILM Corporation
Inventor： Sohichiro NAKAMURA , Ryusuke OSAKI , Sho ONOZAWA , Akihiro ASAKURA
Abstract: Provided is a determination method capable of non-destructively and simply determining a state of a sphere that is an aggregate of a plurality of cells. A phase difference image of a sphere that is an aggregate of a plurality of cells is generated from a hologram obtained by imaging the sphere, and a state of the sphere is determined on the basis of the phase difference image and a shape index value corresponding to a shape of the sphere.
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