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公开(公告)号：US10407662B2
公开(公告)日：2019-09-10
申请号：US15291246
申请日：2016-10-12
Applicant: FUJIFILM Corporation
Inventor： Yuta Murakami , Rie Iwata , Yoshihide Iwaki , Tasuku Sasaki
Abstract: A polypeptide including: (1) a first region containing at least one selected from the group consisting of an amino acid sequence represented by CSYYQSC (SEQ ID NO:1) and an amino acid sequence represented by RGD; and (2) a second region containing (2-i) an amino acid sequence represented by PRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQN (SEQ ID NO:2), (2-ii) an amino acid sequence having an identity of not less than 50% to the amino acid sequence represented by SEQ ID NO:2 and having an adsorption ability to a cultivation container, or (2-iii) an amino acid sequence that is the amino acid sequence represented by SEQ ID NO:2 in which from 1 to 30 amino acid residues are added, substituted, or deleted, and has an adsorption ability to a cultivation container, in which the polypeptide includes from 40 to 450 amino acid residues.
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公开(公告)号：US09932557B2
公开(公告)日：2018-04-03
申请号：US14640218
申请日：2015-03-06
Applicant: FUJIFILM Corporation
Inventor： Yuichi Yoshino , Rie Iwata , Kentaro Nakamura
CPC classification number: C12N5/0655 , A61K38/00 , A61L27/227 , A61L2300/252 , A61L2430/06 , C07K14/78 , C12N2501/998
Abstract: A polypeptide having an amino acid sequence in which the number of RGD sequences contained per molecular weight of 10 kDa is not less than 0.30; the number of GFPGER sequences contained per molecular weight of 10 kDa is not less than 0.15; and the number of GVMGFP sequences contained per molecular weight of 10 kDa is less than 0.30; is provided. A scaffold composition, a composition for repairing a cartilage tissue, a composition for culturing cartilage cells, and a composition for promoting glycosaminoglycan production, which compositions contain the above polypeptide, are also provided.
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