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公开(公告)号：US10980858B2
公开(公告)日：2021-04-20
申请号：US16226348
申请日：2018-12-19
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura , Sayako Kozakai
IPC: A61P29/00 , A61K38/19 , A61K35/28 , A61P1/00 , A61K47/36 , A61K47/42 , C07K14/78 , A61K41/17 , A61K47/60 , A61K9/00 , A61K9/107 , A61K9/70 , A61K38/01 , A61K38/39 , A61K47/34
Abstract: An object of the present invention is to provide a trophic factor releasing agent and an inflammatory disease treating agent in which an amount of trophic factors released from cells in a cell transplantation treatment or the like is increased. According to the present invention, there is provided a trophic factor releasing agent including a cell structure that includes biocompatible polymer blocks and cells and in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the cells, in which a size of one of the biocompatible polymer blocks is 20 μm to 200 μm, and trophic factors are released from the cells.
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公开(公告)号：US10471180B2
公开(公告)日：2019-11-12
申请号：US15374604
申请日：2016-12-09
Applicant: FUJIFILM Corporation
Inventor： Reiko Iwazawa , Kentaro Nakamura
Abstract: An object of the present invention is to provide a cell structure which does not contain glutaraldehyde and can form blood vessels after transplantation, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and has voids and in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, in which a ratio of the volume of the biocompatible macromolecular blocks with respect to the volume of the cell structure is 10% to 30%, a ratio of the volume of the cells with respect to the volume of the cell structure is 20% to 50%, and a ratio of the volume of the voids with respect to the volume of the cell structure is 35% to 60%.
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公开(公告)号：US12018282B2
公开(公告)日：2024-06-25
申请号：US16870388
申请日：2020-05-08
Applicant: FUJIFILM Corporation , Tokushima University
Inventor： Kentaro Nakamura , Mitsuo Shimada , Tetsuya Ikemoto
CPC classification number: C12N5/0676 , C12N2500/38 , C12N2501/12 , C12N2501/16 , C12N2501/335 , C12N2506/1384
Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition. According to the present invention, there is provided a method for producing an insulin-producing cell from a mesenchymal stem cell, including (a) a step of producing a cell structure by incubating a plurality of biocompatible macromolecular blocks and a plurality of mesenchymal stem cells, and (b) a step of culturing one or more of the mesenchymal stem cells before the incubation in the step (a), the mesenchymal stem cell in the incubation in the step (a), or the cell structure produced in the step (a) in a medium containing the GLP-1 receptor agonist, and (c) a step of culturing the cell structure obtained in the step (a) or the step (b) in a medium containing the water-soluble vitamin and the hepatocyte growth factor.
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公开(公告)号：US10898612B2
公开(公告)日：2021-01-26
申请号：US15866735
申请日：2018-01-10
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura
Abstract: An object of the present invention is to provide a cell structure which can be produced within a short period of time and has a predetermined or larger size, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure including: a biocompatible macromolecular block; and two or more kinds of cells, in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, and in which the two or more kinds of cells contain at least one kind of first cell selected from the group consisting of vascular endothelial cells, cardiac muscle cells, pancreatic islet cells, liver cells, epithelial cells, endothelial cells, nerve cells, embryonic stem cells, induced pluripotent stem cells, corneal epithelial cells, and retinal pigment epithelial cells, and at least one kind of second cell selected from the group consisting of mesenchymal cells, stromal cells, fibroblasts, smooth muscle cells, myoblasts, mesenchymal stem cells, adipose-derived stem cells, and umbilical cord-derived stem cells.
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公开(公告)号：US20190192632A1
公开(公告)日：2019-06-27
申请号：US16226348
申请日：2018-12-19
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura , Sayako Kozakai
IPC: A61K38/19 , A61K35/28 , A61K38/01 , A61K38/39 , A61K9/00 , A61K9/70 , A61K9/107 , A61K41/00 , A61K47/34 , A61K47/60
CPC classification number: A61K38/19 , A61K9/0002 , A61K9/0024 , A61K9/1075 , A61K9/703 , A61K35/28 , A61K38/014 , A61K38/39 , A61K41/0019 , A61K47/34 , A61K47/36 , A61K47/42 , A61K47/60 , A61P1/00 , A61P29/00 , C07K14/78
Abstract: An object of the present invention is to provide a trophic factor releasing agent and an inflammatory disease treating agent in which an amount of trophic factors released from cells in a cell transplantation treatment or the like is increased. According to the present invention, there is provided a trophic factor releasing agent including a cell structure that includes biocompatible polymer blocks and cells and in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the cells, in which a size of one of the biocompatible polymer blocks is 20 μm to 200 μm, and trophic factors are released from the cells.
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Patent Agency Ranking
公开(公告)号：US11471564B2
公开(公告)日：2022-10-18
申请号：US16804823
申请日：2020-02-28
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura , Ryo Kogawa
Abstract: An object of the present invention is to provide an angiogenic agent that can sufficiently exhibit an angiogenic effect due to mesenchymal stem cells in a state where the angiogenic agent does not allow permeation of host cells while being protected from immune rejection, and a method for method for manufacturing the same. According to the present invention, an angiogenic agent including a mesenchymal stem cell (A); and an immunoisolation membrane (B) that encloses the mesenchymal stem cell is provided.
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公开(公告)号：US11439960B2
公开(公告)日：2022-09-13
申请号：US16805075
申请日：2020-02-28
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura , Ryo Kogawa , Yusuke Mochizuki , Ryuta Takegami
Abstract: An object of the present invention is to provide a cell transplant device having an ability to induce angiogenesis around the cell transplant device, and a method for manufacturing the same. According to the present invention, a cell transplant device including a cell structure (A) that includes a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure is provided.
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8.发明授权公开(公告)号：US11045587B2
公开(公告)日：2021-06-29
申请号：US16408894
申请日：2019-05-10
Applicant: FUJIFILM Corporation
Inventor： Yusuke Mochizuki , Kentaro Nakamura , Shigeaki Ohtani , Naohiro Matsunaga , Ryuta Takegami
IPC: A61L31/14 , A61L27/16 , A61F2/02 , A61L27/18 , A61L27/38 , A61L31/16 , A61L31/04 , A61K9/00 , A61K38/28
Abstract: According to the present invention, there is provided a membrane for immunoisolation, including a porous membrane that contains a polymer, in which Formulas (I) and (II) are satisfied for at least one surface of the porous membrane, B/A≤0.7 (I) and A≥0.015 (II) (in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane); a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation includes the above-described chamber for transplantation enclosing the above-described biological constituent therein. The membrane for immunoisolation of the present invention has a high bioaffinity.
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公开(公告)号：US11027044B2
公开(公告)日：2021-06-08
申请号：US15941187
申请日：2018-03-30
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura
Abstract: An object of the present invention is to provide a method for producing a sheet-like cell structure having excellent strength and shape-maintaining performance, and a sheet-like cell structure having excellent strength and shape-maintaining performance. According to the present invention, there is provided a method for producing a sheet-like cell structure, including: a step of adding a biocompatible macromolecular block, a cell, and a liquid medium onto a culture support body having a plurality of recessed portions on a culture surface, and immersing the biocompatible macromolecular block and the cell in uppermost portions of the recessed portions; and a step of culturing the cell to obtain a sheet-like cell structure.
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公开(公告)号：US10576184B2
公开(公告)日：2020-03-03
申请号：US15499977
申请日：2017-04-28
Applicant: FUJIFILM Corporation
Inventor： Kentaro Nakamura
Abstract: An object of the present invention is to provide a cell-containing bioabsorbable tubular structure having molecular permeability, a device for manufacturing the tubular structure, and a method for manufacturing the tubular structure. According to the present invention, there is provided a tubular structure constituted with a cell structure which contains biocompatible polymer blocks and cells, in which the plurality of polymer blocks is disposed in voids between the plurality of cells.
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