公开(公告)号：US20240108607A1

公开(公告)日：2024-04-04

申请号：US18112423

申请日：2023-02-21

Applicant: FUJIFILM Corporation

Inventor： Hirofumi FUKUNAGA ,  Sachiko SHINJO ,  Daisuke NAKAGAWA ,  Shinichiro SEKINE ,  Takayuki YAMAKAWA

IPC: A61K31/4375 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/395 ,  A61K31/555 ,  A61K31/785 ,  A61K51/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07D471/04 ,  C07D487/00 ,  C07F1/08 ,  C07F5/00

CPC classification number: A61K31/4375 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/395 ,  A61K31/555 ,  A61K31/785 ,  A61K51/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07D471/04 ,  C07D487/00 ,  C07F1/08 ,  C07F5/00

Abstract: A compound represented by Formula [3] or a salt thereof and a method of making the






in the formula, L3 represents a group represented by Formula [2c]










wherein R3c, R4c, R5c and R6c are the same as or different from each other and represent a hydrogen atom or a C1-6 alkyl group; p3 represents an integer of 1 to 3; q3 represents an integer of 0 to 3; and r3 represents an integer of 1 to 6; A1 represents any one of the groups represented by Formulae [4] to [9],










wherein * represents a binding position; and R7 represents a carboxyl-protecting group; and m represents an integer of 1 to 3.

公开(公告)号：US20210015802A1

公开(公告)日：2021-01-21

申请号：US17037103

申请日：2020-09-29

Applicant: FUJIFILM Corporation

Inventor： Hirofumi FUKUNAGA ,  Sachiko SHINJO ,  Daisuke NAKAGAWA ,  Shinichiro SEKINE ,  Takayuki YAMAKAWA

IPC: A61K31/4375 ,  A61K31/395 ,  A61K31/555 ,  C07F5/00 ,  C07D257/02 ,  C07D255/02 ,  C07F1/08 ,  C07D471/04 ,  A61K51/00 ,  C07B59/00 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/785 ,  C07D487/00

Abstract: A compound represented by Formula [3] or a salt thereof and a method of making the same, in the formula, L3 represents a group represented by Formula [2c] wherein R3c, R4c, R5c, and R6c are the same as or different from each other and represent a hydrogen atom or a C1-6 alkyl group; p3 represents an integer of 1 to 3; q3 represents an integer of 0 to 3; and r3 represents an integer of 1 to 6; A1 represents any one of the groups represented by Formulae [4] to [9], wherein * represents a binding position; and R7 represents a carboxyl-protecting group; and m represents an integer of 1 to 3.

公开(公告)号：US20180008583A1

公开(公告)日：2018-01-11

申请号：US15712815

申请日：2017-09-22

Applicant: FUJIFILM Corporation

Inventor： Hirofumi FUKUNAGA ,  Sachiko SHINJO ,  Daisuke NAKAGAWA ,  Shinichiro SEKINE ,  Takayuki YAMAKAWA

IPC: A61K31/4375 ,  A61K31/27 ,  A61K31/145 ,  A61K31/223 ,  C07D487/00 ,  A61K31/785

Abstract: Provided are a method for efficiently manufacturing a nitrogen-containing compound, which is used for manufacturing a treatment agent for integrin-related diseases, or a salt thereof and a manufacturing intermediate of the compound or a salt thereof.A method for manufacturing a novel nitrogen-containing compound or a salt thereof includes (1) a step of obtaining a compound represented by Formula [10] or a salt thereof through an amidation reaction; and (2) a step of deprotecting the compound represented by Formula [10] or a salt thereof.