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    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF, USE THEREOF, AND INTERMEDIATE THEREOF
    2.
    发明公开
    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF, USE THEREOF, AND INTERMEDIATE THEREOF 审中-公开

    公开(公告)号：US20230167074A1

    公开(公告)日：2023-06-01

    申请号：US18160690

    申请日：2023-01-27

    Applicant: FUJIFILM Corporation

    Inventor： Takayuki YAMAKAWA ,  Yasuhiro TSUTSUI

    IPC: C07D241/28 ,  A61P35/02 ,  C07D405/12 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D405/04

    CPC classification number: C07D241/28 ,  A61P35/02 ,  C07D405/12 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D405/04

    Abstract: An object of the present invention is to provide a compound useful as an anti-tumor agent or the like; an intermediate thereof; and a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, there is provided a compound represented by General Formula (1) or a salt thereof:






    in the formula, Z1, Z2, and Z3 are the same as or different from each other and represent a nitrogen atom or CH; Z4 represents a nitrogen atom or a general formula of CR6; Z5 represents a nitrogen atom or a general formula of CR7 provided that at least one of Z1, Z2, Z3, Z4, or Z5 represents a nitrogen atom; R1 represents a general formula of CONHR8 or the like; R2 represents a C3-8 cycloalkyl group which may be substituted or the like; R3, R5, R6, and R7 are the same as or different from each other and represent a hydrogen atom, a halogen atom, or the like; R4 represents an aryl group which may be substituted or a heterocyclic group which may be substituted; R8 represents a general formula of SO2R9 or the like; and R9 represents an amino group which may be protected or the like.

    PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME
    3.
    发明申请
    PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME 有权

    公开(公告)号：US20220259185A1

    公开(公告)日：2022-08-18

    申请号：US17732717

    申请日：2022-04-29

    Applicant: FUJIFILM Corporation

    Inventor： Takayuki YAMAKAWA ,  Yasuhiro Tsutsui

    IPC: C07D405/12

    Abstract: An object of the present invention is to provide a compound useful as an anti-tumor agent or the like, as well as a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, a compound represented by General Formula (1) or a salt thereof is provided. In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; R2, R3, R4, and R5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted, a C1-6 alkoxy group which may be substituted, or the like; R6's are the same as or different from each other and each represent a halogen atom, a C1-6 alkyl group which may be substituted, or a C1-6 alkoxy group which may be substituted; R7 represents a C3-8 cycloalkyl group which may be substituted, or the like; m represents an integer of 0 to 6; and a broken line represents a single bond or a double bond.

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