公开(公告)号：US20240099975A1

公开(公告)日：2024-03-28

申请号：US18517448

申请日：2023-11-22

Applicant: FUJIFILM Corporation

Inventor： Susumu SHIMOYAMA ,  Keiko SUZUKI ,  Mikinaga MORI ,  Takeshi MATSUMOTO ,  Shinji NAKAYAMA ,  Yasushi MOROHASHI ,  Toshifumi KIMURA

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/4745 ,  A61K33/04 ,  A61K47/10 ,  A61K47/28 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K9/1271 ,  A61K9/0019 ,  A61K31/4745 ,  A61K33/04 ,  A61K47/10 ,  A61K47/28 ,  A61K47/544 ,  A61P35/00

Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.