公开(公告)号：US20240099975A1

公开(公告)日：2024-03-28

申请号：US18517448

申请日：2023-11-22

Applicant: FUJIFILM Corporation

Inventor： Susumu SHIMOYAMA ,  Keiko SUZUKI ,  Mikinaga MORI ,  Takeshi MATSUMOTO ,  Shinji NAKAYAMA ,  Yasushi MOROHASHI ,  Toshifumi KIMURA

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/4745 ,  A61K33/04 ,  A61K47/10 ,  A61K47/28 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K9/1271 ,  A61K9/0019 ,  A61K31/4745 ,  A61K33/04 ,  A61K47/10 ,  A61K47/28 ,  A61K47/544 ,  A61P35/00

Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.

公开(公告)号：US20170296465A1

公开(公告)日：2017-10-19

申请号：US15486312

申请日：2017-04-13

Applicant: FUJIFILM Corporation

Inventor： Junya YOSHIDA ,  Ikuo KAWAUCHI ,  Yasushi MOROHASHI

IPC: A61K9/00 ,  A61K47/26 ,  A61K47/36 ,  A61M37/00 ,  A61K38/27 ,  B29C39/02 ,  B29C39/26 ,  B29L31/00 ,  B29K105/00

CPC classification number: A61K9/0021 ,  A61K38/27 ,  A61K47/26 ,  A61K47/36 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  B29C39/026 ,  B29C39/26 ,  B29K2105/0035 ,  B29K2105/0058 ,  B29K2883/00 ,  B29L2031/00 ,  B29L2031/7544 ,  B29L2031/756

Abstract: To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy.Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 μm≦L2≦L−L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is μm.