专利检索 ap:("FUJIFILM Corporation" OR "Assistance Publique - Hôpitaux de Paris") AND inv:"Guillaume Churlaud" 第 1 页

1.

发明公开
GENERATION OF SECRETOME-CONTAINING COMPOSITIONS, AND METHODS OF USING AND ANALYZING THE SAME 审中-公开

公开(公告)号：US20230365936A1

公开(公告)日：2023-11-16

申请号：US18319224

申请日：2023-05-17

申请人： FUJIFILM Corporation , Assistance Publique - Hôpitaux de Paris

发明人： Nisa K. E. RENAULT , Michele L. Hamrick , Chad H. Koonce , Philippe Menasche , Valerie Bellamy , Camille Humbert , Guillaume Churlaud , Jerome Larghero

IPC分类号： C12N5/0775 , C12N5/00 , A61P9/10

CPC分类号： C12N5/0662 , C12N5/0031 , A61P9/10 , C12N2501/998 , C12N2501/115

摘要： The present disclosure provides methods for generating and/or purifying secretomes, extracellular vesicles, and fractions thereof, from progenitor cells; and provides compositions containing such generated secretomes, extracellular vesicles, and fractions thereof. The present disclosure further provides methods for analyzing activities, and the functionality and potency, of such secretomes, extracellular vesicles, and fractions thereof. The present disclosure also relates to the therapeutic use of secretomes, extracellular vesicles, and fractions thereof. The present disclosure further relates to a good manufacturing practices (GMP)-ready, scalable, culture protocol for the release of clinic-ready secretomes.