公开(公告)号：US20160153981A1

公开(公告)日：2016-06-02

申请号：US15016028

申请日：2016-02-04

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Masataka NISHIDA ,  Nobumitsu YAMANAKA ,  Kazutomi MIYOSHI ,  Michio OHKUBO

IPC: G01N33/552 ,  G01N33/58

Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

Abstract translation: 表面具有硫醇基的二氧化硅粒子，满足以下条件（a）〜（c）：（a）粒径为20〜1000nm; （b）二氧化硅粒子表面的硫醇基的密度为0.002〜0.2片/ nm 2， 和（c）二氧化硅颗粒表面上存在的硫醇基的量B（片/颗粒）与二氧化硅颗粒中硫元素的量A（硫数）之比（B / A） 源自硫醇/二氧化硅颗粒的元素）为0.10〜0.60。

公开(公告)号：US20140242720A1

公开(公告)日：2014-08-28

申请号：US13778609

申请日：2013-02-27

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Masataka NISHIDA ,  Hideki AIZAWA

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5023 ,  G01N21/645 ,  G01N21/8483 ,  G01N33/558

Abstract: A kit for immunochromatography, having: a planar test strip having a test area and a reference area, the test area having a test purpose capturing substance, the reference area having a reference purpose capturing substance; fluorescent particulates provided with a binding property to a target substance, the target substance provided with a binding property to the test purpose capturing substance; and light absorbing particulates provided with a binding property to the reference purpose capturing substance.

Abstract translation: 一种用于免疫层析的试剂盒，具有：具有测试区域和参考区域的平面测试条，所述测试区域具有测试目的捕获物质，所述参考区域具有参考目的捕获物质; 提供与目标物质的结合性的荧光微粒，所述目标物质与测试目的捕获物质具有结合性; 以及提供与参考目的捕获物质的结合特性的光吸收颗粒。

公开(公告)号：US20140051186A1

公开(公告)日：2014-02-20

申请号：US14063666

申请日：2013-10-25

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Hideki AIZAWA ,  Michio OHKUBO ,  Masataka NISHIDA

IPC: C07K17/14 ,  G01N33/552

CPC classification number: C07K17/14 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/552 ,  G01N33/558 ,  Y10T436/143333

Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.

Abstract translation: 一种制备其上结合有生物分子的含有功能分子的二氧化硅纳米颗粒的方法，包括以下步骤：使含有功能分子的二氧化硅纳米粒子与其表面上的硫醇基团共存于具有马来酰亚胺基和 羧基在非质子溶剂中，从而在硫醇基和马来酰亚胺基之间形成硫醚键，并获得其上键合有连接分子的含功能分子的二氧化硅纳米颗粒; 并且使含有连接体分子的功能性分子的二氧化硅纳米粒子与碳二亚胺和在水性溶剂中具有氨基的生物分子共存，由此可以在由碳二亚胺酯化的羧基之间形成酰胺键，和 生物分子的氨基。

公开(公告)号：US20160291003A1

公开(公告)日：2016-10-06

申请号：US15088742

申请日：2016-04-01

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Masayuki FUKUSHIMA ,  Michio OHKUBO ,  Kazutomi MIYOSHI ,  Masataka NISHIDA

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/552

CPC classification number: G01N33/54333 ,  G01N21/6428 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/552 ,  G01N33/582 ,  G01N2021/6439

Abstract: A method of detecting a target substance, containing the steps of: incorporating labeling particles into a test liquid containing an analyte; heating the test liquid; irradiating the test liquid with excitation light, and detecting the target substance contained in the test liquid depending on a state of light emission of the labeling particles; wherein an aggregation state of the labeling particles is changed by the heating step; and wherein the labeling particles have a thermoresponsive polymer on a surface of a composite particle containing a magnetic material and a fluorescent material, and further have a biomolecule having properties of binding with the target substance.

公开(公告)号：US20190170758A1

公开(公告)日：2019-06-06

申请号：US16267107

申请日：2019-02-04

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Masataka NISHIDA ,  Michio OHKUBO ,  Kazutomi MIYOSHI ,  Masayuki FUKUSHIMA

IPC: G01N33/58 ,  G01N33/552 ,  G01N33/543 ,  B03C1/00 ,  H01F1/00 ,  G01N21/64

Abstract: A fluorescent labeling particle for detecting a target substance, containing a composite particle having a phase containing a magnetic material and a phase containing a fluorescent material, and a thermoresponsive polymer on a surface of the composite particle.

公开(公告)号：US20160216273A1

公开(公告)日：2016-07-28

申请号：US15088758

申请日：2016-04-01

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Masataka NISHIDA ,  Michio OHKUBO ,  Kazutomi MIYOSHI ,  Masayuki FUKUSHIMA

IPC: G01N33/58 ,  G01N33/543

CPC classification number: G01N33/582 ,  B03C1/00 ,  B03C1/01 ,  B82Y25/00 ,  B82Y30/00 ,  C09K11/02 ,  C09K11/025 ,  C09K11/06 ,  G01N21/6428 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/5434 ,  G01N33/552 ,  H01F1/0054

Abstract: A fluorescent labeling particle for detecting a target substance, containing a composite particle having a phase containing a magnetic material and a phase containing a fluorescent material, and a thermoresponsive polymer on a surface of the composite particle.

Abstract translation: 一种用于检测目标物质的荧光标记颗粒，其含有含有磁性材料的相和包含荧光材料的相的复合颗粒和在该复合颗粒的表面上的热反应性聚合物。