METHOD OF PRODUCING LABELED ANTIBODY
    1.
    发明申请
    METHOD OF PRODUCING LABELED ANTIBODY 审中-公开
    生产标签抗体的方法

    公开(公告)号:US20150338395A1

    公开(公告)日:2015-11-26

    申请号:US14816836

    申请日:2015-08-03

    Abstract: A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.

    Abstract translation: 一种制备标记抗体的方法,包括以下步骤:a)使含有功能性分子的二氧化硅纳米粒子和表面上具有硫醇基的二氧化硅纳米粒子和含有马来酰亚胺基和氨基的连接体共存于溶剂中 在硫醇基和马来酰亚胺基之间形成硫醚键,从而得到其上键合有连接分子的含功能分子的二氧化硅纳米粒子; b)使含有连接子分子键合的功能性分子的二氧化硅纳米粒子,碳二亚胺和抗体在水性溶剂中共存,从而在连接分子的氨基与抗体的羧基之间形成酰胺键。

    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD OF PRODUCING THE SAME
    2.
    发明申请
    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD OF PRODUCING THE SAME 审中-公开
    具有表面反应性官能团的二氧化硅颗粒及其生产方法

    公开(公告)号:US20160153981A1

    公开(公告)日:2016-06-02

    申请号:US15016028

    申请日:2016-02-04

    Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

    Abstract translation: 表面具有硫醇基的二氧化硅粒子,满足以下条件(a)〜(c):(a)粒径为20〜1000nm; (b)二氧化硅粒子表面的硫醇基的密度为0.002〜0.2片/ nm 2, 和(c)二氧化硅颗粒表面上存在的硫醇基的量B(片/颗粒)与二氧化硅颗粒中硫元素的量A(硫数)之比(B / A) 源自硫醇/二氧化硅颗粒的元素)为0.10〜0.60。

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