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1.发明申请公开(公告)号：US20100179415A1
公开(公告)日：2010-07-15
申请号：US12665783
申请日：2008-05-27
申请人： Fabian Wenzel , Stewart Young , Torjoern Vik , Frank O. Thiele , Ralph Buchert
发明人： Fabian Wenzel , Stewart Young , Torjoern Vik , Frank O. Thiele , Ralph Buchert
IPC分类号： A61B5/055
CPC分类号： G06T7/0012 , G06T2200/24 , G06T2207/10104 , G06T2207/20092 , G06T2207/30016
摘要： When detecting and classifying hypo-metabolic regions in the brain to facilitate dementia diagnosis, a patient's brain scan image, generated using an FDG-PET scan, is compared to a plurality of hypo-metabolic region patterns in brain scan images associated with a plurality of types of dementia. In a fully automated mode, the patient's scan is compared to all scans stored in a knowledge base, and a type of dementia associated with a most likely match is output to a user along with a highlighted image of the patient' s brain. In a semi-automated mode, a user specifies two or more types of dementia, and the patient's scan is compared to scans typical of the specified types. Diagnosis information including respective likelihoods for each type is then output to the user. Additionally, the user can adjust a threshold significance level to increase or decrease a number of voxels that are included in hypo-metabolic regions highlighted in the patient' brain scan image.
摘要翻译： 当检测和分类大脑中的低代谢区域以促进痴呆诊断时，将使用FDG-PET扫描产生的患者的脑扫描图像与多个相关联的脑扫描图像中的多个低代谢区域模式进行比较 痴呆症类型。 在完全自动化模式下，将患者的扫描与存储在知识库中的所有扫描进行比较，并将与最可能匹配的类型的痴呆一起输出到患者大脑的突出显示的图像。 在半自动模式下，用户指定两种或更多种类型的痴呆，并将患者的扫描与特定类型的典型扫描进行比较。 然后，向用户输出包括各种类型的各自可能性的诊断信息。 此外，用户可以调整阈值显着性水平以增加或减少患者脑扫描图像中突出显示的次代谢区域中包含的体素数量。
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2.发明授权Model-based differential diagnosis of dementia and interactive setting of level of significance 有权基于模型的痴呆鉴别诊断和交互设置的意义水平公开(公告)号：US08423118B2
公开(公告)日：2013-04-16
申请号：US12665783
申请日：2008-05-27
申请人： Fabian Wenzel , Stewart Young , Torjoern Vik , Frank O. Thiele , Ralph Buchert
发明人： Fabian Wenzel , Stewart Young , Torjoern Vik , Frank O. Thiele , Ralph Buchert
IPC分类号： A61B5/00
CPC分类号： G06T7/0012 , G06T2200/24 , G06T2207/10104 , G06T2207/20092 , G06T2207/30016
摘要： When detecting and classifying hypo-metabolic regions in the brain to facilitate dementia diagnosis, a patient's brain scan image, generated using an FDG-PET scan, is compared to a plurality of hypo-metabolic region patterns in brain scan images associated with a plurality of types of dementia. In a fully automated mode, the patient's scan is compared to all scans stored in a knowledge base, and a type of dementia associated with a most likely match is output to a user along with a highlighted image of the patient' s brain. In a semi-automated mode, a user specifies two or more types of dementia, and the patient's scan is compared to scans typical of the specified types. Diagnosis information including respective likelihoods for each type is then output to the user. Additionally, the user can adjust a threshold significance level to increase or decrease a number of voxels that are included in hypo-metabolic regions highlighted in the patient' brain scan image.
摘要翻译： 当检测和分类大脑中的低代谢区域以促进痴呆诊断时，将使用FDG-PET扫描产生的患者的脑扫描图像与多个相关联的脑扫描图像中的多个低代谢区域模式进行比较 痴呆症类型。 在完全自动化模式下，将患者的扫描与存储在知识库中的所有扫描进行比较，并将与最可能匹配的类型的痴呆一起输出到患者大脑的突出显示的图像。 在半自动模式下，用户指定两种或更多种类型的痴呆，并将患者的扫描与特定类型的典型扫描进行比较。 然后，向用户输出包括各种类型的各自可能性的诊断信息。 此外，用户可以调整阈值显着性水平以增加或减少患者脑扫描图像中突出显示的次代谢区域中包含的体素数量。
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公开(公告)号：US20110293143A1
公开(公告)日：2011-12-01
申请号：US13147402
申请日：2010-01-12
IPC分类号： G06K9/00
CPC分类号： G06T7/0028 , A61B6/037 , G06T7/33 , G06T2207/10104 , G06T2207/30004 , G06T2207/30204
摘要： A method includes generating a kinetic parameter value for a VOI in a functional image of a subject based on motion corrected projection data using an iterative algorithm, including determining a motion correction for projection data corresponding to the VOI based on the VOI, motion correcting the projection data corresponding to the VOI to generate the motion corrected projection data, and estimating the at least one kinetic parameter value based on the motion corrected projection data or image data generated with the motion corrected projection data. In another embodiment, a method includes registering functional image data indicative of tracer uptake in a scanned patient with image data from a different imaging modality, identifying a VOI in the image based on the registered images, generating at least one kinetic parameter for the VOI, and generating a feature vector including the at least one generated kinetic parameter and at least one bio- marker.
摘要翻译： 一种方法包括：使用迭代算法，基于运动校正的投影数据，生成用于对象的功能图像中的VOI的动力学参数值，包括基于所述VOI确定对应于所述VOI的投影数据的运动校正，校正所述投影的运动 对应于VOI的数据以生成运动校正的投影数据，以及基于运动校正的投影数据或利用运动校正的投影数据生成的图像数据来估计至少一个动力学参数值。 在另一个实施例中，一种方法包括将来自不同成像模式的图像数据指示在扫描患者中的示踪剂吸收的功能图像数据，基于注册图像识别图像中的VOI，为VOI生成至少一个动力学参数， 以及生成包括所述至少一个生成的动力学参数和至少一个生物标志物的特征向量。
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公开(公告)号：US08805036B2
公开(公告)日：2014-08-12
申请号：US13144172
申请日：2009-12-09
申请人： Frank O. Thiele , Satoshi Minoshima
发明人： Frank O. Thiele , Satoshi Minoshima
IPC分类号： G06K9/00
CPC分类号： A61B5/4848 , G06F19/00 , G06Q10/06313 , G06T7/0012 , G06T7/30 , G06T7/344 , G06T2207/10072 , G06T2207/30004 , G16H10/40
摘要： A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial. The method further includes co-registering the images and mapping the co-registered images to a reference image representing the region of interest. The method further includes generating a trial image of the region of interest showing at least one of structural or functional physiological changes that occurred during the trial time period based on the mapped co-registered images, and displaying the trial image.
摘要翻译： 用于评估试验中的治疗的方法包括获得从在受试者的相同感兴趣区域的试验时间段期间的不同时间获取的图像数据生成的图像。 该治疗被用于受试者的试验。 该方法还包括共同配准图像并将共同注册的图像映射到表示感兴趣区域的参考图像。 该方法还包括产生感兴趣区域的试验图像，其显示基于所映射的共同注册的图像在试用时间段期间发生的结构或功能生理变化中的至少一个，并显示试验图像。
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公开(公告)号：US09420972B2
公开(公告)日：2016-08-23
申请号：US14334757
申请日：2014-07-18
申请人： Frank O. Thiele , Satoshi Minoshima
发明人： Frank O. Thiele , Satoshi Minoshima
CPC分类号： A61B5/4848 , G06F19/00 , G06Q10/06313 , G06T7/0012 , G06T7/30 , G06T7/344 , G06T2207/10072 , G06T2207/30004 , G16H10/40
摘要： A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial. The method further includes co-registering the images and mapping the co-registered images to a reference image representing the region of interest. The method further includes generating a trial image of the region of interest showing at least one of structural or functional physiological changes that occurred during the trial time period based on the mapped co-registered images, and displaying the trial image.
摘要翻译： 用于评估试验中的治疗的方法包括获得从在受试者的相同感兴趣区域的试验时间段期间的不同时间获取的图像数据生成的图像。 该治疗被用于受试者的试验。 该方法还包括共同配准图像并将共同注册的图像映射到表示感兴趣区域的参考图像。 该方法还包括产生感兴趣区域的试验图像，其显示基于所映射的共同注册的图像在试用时间段期间发生的结构或功能生理变化中的至少一个，并显示试验图像。
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公开(公告)号：US20110263949A1
公开(公告)日：2011-10-27
申请号：US13144172
申请日：2009-12-09
申请人： Frank O. Thiele , Satoshi Minoshima
发明人： Frank O. Thiele , Satoshi Minoshima
CPC分类号： A61B5/4848 , G06F19/00 , G06Q10/06313 , G06T7/0012 , G06T7/30 , G06T7/344 , G06T2207/10072 , G06T2207/30004 , G16H10/40
摘要： A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial. The method further includes co-registering the images and mapping the co-registered images to a reference image representing the region of interest. The method further includes generating a trial image of the region of interest showing at least one of structural or functional physiological changes that occurred during the trial time period based on the mapped co-registered images, and displaying the trial image.
摘要翻译： 用于评估试验中的治疗的方法包括获得从在受试者的相同感兴趣区域的试验时间段期间的不同时间获取的图像数据生成的图像。 该治疗被用于受试者的试验。 该方法还包括共同配准图像并将共同注册的图像映射到表示感兴趣区域的参考图像。 该方法还包括产生感兴趣区域的试验图像，其显示基于所映射的共同注册的图像在试用时间段期间发生的结构或功能生理变化中的至少一个，并显示试验图像。
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公开(公告)号：US08787643B2
公开(公告)日：2014-07-22
申请号：US13147402
申请日：2010-01-12
CPC分类号： G06T7/0028 , A61B6/037 , G06T7/33 , G06T2207/10104 , G06T2207/30004 , G06T2207/30204
摘要： A method includes generating a kinetic parameter value for a VOI in a functional image of a subject based on motion corrected projection data using an iterative algorithm, including determining a motion correction for projection data corresponding to the VOI based on the VOI, motion correcting the projection data corresponding to the VOI to generate the motion corrected projection data, and estimating the at least one kinetic parameter value based on the motion corrected projection data or image data generated with the motion corrected projection data. In another embodiment, a method includes registering functional image data indicative of tracer uptake in a scanned patient with image data from a different imaging modality, identifying a VOI in the image based on the registered images, generating at least one kinetic parameter for the VOI, and generating a feature vector including the at least one generated kinetic parameter and at least one bio-marker.
摘要翻译： 一种方法包括：使用迭代算法，基于运动校正的投影数据，生成用于对象的功能图像中的VOI的动力学参数值，包括基于所述VOI确定对应于所述VOI的投影数据的运动校正，校正所述投影的运动 对应于VOI的数据以生成运动校正的投影数据，以及基于运动校正的投影数据或利用运动校正的投影数据生成的图像数据来估计至少一个动力学参数值。 在另一个实施例中，一种方法包括将来自不同成像模式的图像数据指示在扫描患者中的示踪剂吸收的功能图像数据，基于注册图像识别图像中的VOI，为VOI生成至少一个动力学参数， 以及生成包括所述至少一个生成的动力学参数和至少一个生物标记的特征向量。
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公开(公告)号：US08692681B2
公开(公告)日：2014-04-08
申请号：US13382191
申请日：2010-06-15
IPC分类号： G08B21/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A nuclear imaging system includes a scanner (8), such as a PET scanner. A patient is injected with a [13N]ammonia radioisotope tracer which is contaminated with a small percent of 18F contamination. The scanner receives radiation from the injected tracer and a reconstruction processor (28) reconstructs the detected radiation into image representations. A calibration processor (16) generates an estimated decay curve based on the proton bombardment and a priori information about the tracer. An activity meter (42) measures radiation emitted from a sample of the tracer and a dose calibrator (44) determines a decay curve from the measured radiation. The detected radiation is corrected with one of the decay curves during reconstruction or a correction processor (50) corrects reconstructed images with one or both of the decay curves. A display (14) displays uncorrected reconstructed images and the decay curve and/or the corrected images.
摘要翻译： 核成像系统包括诸如PET扫描仪的扫描器（8）。 注射一个[13N]氨放射性同位素示踪剂，其被少量的18F污染物污染。 扫描仪接收来自被注入示踪剂的辐射，并且重建处理器（28）将检测到的辐射重建成图像表示。 校准处理器（16）基于质子轰击和关于示踪器的先验信息产生估计衰减曲线。 活性计量器（42）测量从示踪剂的样品发射的辐射，剂量校准器（44）从测量的辐射确定衰减曲线。 在重建过程中用一个衰减曲线来校正检测到的辐射，或者校正处理器（50）用一个或两个衰减曲线校正重建图像。 显示器（14）显示未校正的重建图像和衰减曲线和/或校正图像。
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公开(公告)号：US20120098671A1
公开(公告)日：2012-04-26
申请号：US13382191
申请日：2010-06-15
CPC分类号： G01T1/2985 , A61B6/037
摘要： A nuclear imaging system includes a scanner (8), such as a PET scanner. A patient is injected with a [13N]ammonia radioisotope tracer which is contaminated with a small percent of 18F contamination. The scanner receives radiation from the injected tracer and a reconstruction processor (28) reconstructs the detected radiation into image representations. A warning generator (12) generates warnings to the clinician concerning the effects of the 18F contamination. A calibration processor (16) generates an estimated decay curve based on a time since the end of the proton bombardment which created the tracer and a priori information about the tracer. An activity meter (42) measures radiation emitted from a sample of the tracer and a dose calibrator (44) determines a decay curve from the measured radiation. Either the detected radiation is corrected in accordance with one of the decay curves during reconstruction or a correction processor (50) corrects reconstructed images in accordance with one or both of the decay curves. A display (14) displays uncorrected reconstructed images and the decay curve and/or the corrected images.
摘要翻译： 核成像系统包括诸如PET扫描仪的扫描器（8）。 注射一个[13N]氨放射性同位素示踪剂，其被少量的18F污染物污染。 扫描仪接收来自被注入示踪剂的辐射，并且重建处理器（28）将检测到的辐射重建成图像表示。 警告发生器（12）向临床医生发出关于18F污染的影响的警告。 校准处理器（16）基于自产生示踪剂的质子轰击结束以及关于示踪剂的先验信息之后的时间产生估计衰减曲线。 活性计量器（42）测量从示踪剂的样品发射的辐射，剂量校准器（44）从测量的辐射确定衰减曲线。 根据重建期间的衰减曲线之一校正检测到的辐射，或者校正处理器（50）根据衰减曲线中的一个或两个来校正重建图像。 显示器（14）显示未校正的重建图像和衰减曲线和/或校正图像。
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