公开(公告)号：US08423118B2

公开(公告)日：2013-04-16

申请号：US12665783

申请日：2008-05-27

申请人： Fabian Wenzel ,  Stewart Young ,  Torjoern Vik ,  Frank O. Thiele ,  Ralph Buchert

发明人： Fabian Wenzel ,  Stewart Young ,  Torjoern Vik ,  Frank O. Thiele ,  Ralph Buchert

IPC分类号： A61B5/00

CPC分类号： G06T7/0012 ,  G06T2200/24 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30016

摘要： When detecting and classifying hypo-metabolic regions in the brain to facilitate dementia diagnosis, a patient's brain scan image, generated using an FDG-PET scan, is compared to a plurality of hypo-metabolic region patterns in brain scan images associated with a plurality of types of dementia. In a fully automated mode, the patient's scan is compared to all scans stored in a knowledge base, and a type of dementia associated with a most likely match is output to a user along with a highlighted image of the patient' s brain. In a semi-automated mode, a user specifies two or more types of dementia, and the patient's scan is compared to scans typical of the specified types. Diagnosis information including respective likelihoods for each type is then output to the user. Additionally, the user can adjust a threshold significance level to increase or decrease a number of voxels that are included in hypo-metabolic regions highlighted in the patient' brain scan image.

摘要翻译： 当检测和分类大脑中的低代谢区域以促进痴呆诊断时，将使用FDG-PET扫描产生的患者的脑扫描图像与多个相关联的脑扫描图像中的多个低代谢区域模式进行比较 痴呆症类型。 在完全自动化模式下，将患者的扫描与存储在知识库中的所有扫描进行比较，并将与最可能匹配的类型的痴呆一起输出到患者大脑的突出显示的图像。 在半自动模式下，用户指定两种或更多种类型的痴呆，并将患者的扫描与特定类型的典型扫描进行比较。 然后，向用户输出包括各种类型的各自可能性的诊断信息。 此外，用户可以调整阈值显着性水平以增加或减少患者脑扫描图像中突出显示的次代谢区域中包含的体素数量。

公开(公告)号：US20100179415A1

公开(公告)日：2010-07-15

申请号：US12665783

申请日：2008-05-27

申请人： Fabian Wenzel ,  Stewart Young ,  Torjoern Vik ,  Frank O. Thiele ,  Ralph Buchert

发明人： Fabian Wenzel ,  Stewart Young ,  Torjoern Vik ,  Frank O. Thiele ,  Ralph Buchert

IPC分类号： A61B5/055

CPC分类号： G06T7/0012 ,  G06T2200/24 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30016

摘要： When detecting and classifying hypo-metabolic regions in the brain to facilitate dementia diagnosis, a patient's brain scan image, generated using an FDG-PET scan, is compared to a plurality of hypo-metabolic region patterns in brain scan images associated with a plurality of types of dementia. In a fully automated mode, the patient's scan is compared to all scans stored in a knowledge base, and a type of dementia associated with a most likely match is output to a user along with a highlighted image of the patient' s brain. In a semi-automated mode, a user specifies two or more types of dementia, and the patient's scan is compared to scans typical of the specified types. Diagnosis information including respective likelihoods for each type is then output to the user. Additionally, the user can adjust a threshold significance level to increase or decrease a number of voxels that are included in hypo-metabolic regions highlighted in the patient' brain scan image.

摘要翻译： 当检测和分类大脑中的低代谢区域以促进痴呆诊断时，将使用FDG-PET扫描产生的患者的脑扫描图像与多个相关联的脑扫描图像中的多个低代谢区域模式进行比较 痴呆症类型。 在完全自动化模式下，将患者的扫描与存储在知识库中的所有扫描进行比较，并将与最可能匹配的类型的痴呆一起输出到患者大脑的突出显示的图像。 在半自动模式下，用户指定两种或更多种类型的痴呆，并将患者的扫描与特定类型的典型扫描进行比较。 然后，向用户输出包括各种类型的各自可能性的诊断信息。 此外，用户可以调整阈值显着性水平以增加或减少患者脑扫描图像中突出显示的次代谢区域中包含的体素数量。

公开(公告)号：US08488857B2

公开(公告)日：2013-07-16

申请号：US12529195

申请日：2008-02-14

申请人： Stewart M. Young ,  Michael Kuhn ,  Fabian Wenzel ,  Ingwer C. Carlsen ,  Kirsten Meetz ,  Ralph Buchert

发明人： Stewart M. Young ,  Michael Kuhn ,  Fabian Wenzel ,  Ingwer C. Carlsen ,  Kirsten Meetz ,  Ralph Buchert

IPC分类号： G06K9/00 ,  G06K9/62 ,  A61B5/02

CPC分类号： A61B6/5247 ,  A61B5/0035 ,  A61B5/055 ,  A61B5/4088 ,  A61B6/037 ,  A61B6/507

摘要： A scanner (10) is used to provide images for automated diagnoses of neurodegenerative diseases, such as Alzheimers disease. The images are registered (90) to a template (78). The aligned image is analyzed (60) in relation to reference image data (76, 80) which has been registered to the template which is contained in a knowledge maintenance engine (70) for similar patterns of hypo-intensity that would indicate (in the case of an FDG tracer) reduced glucose uptake in the brain. The most appropriate reference images for the analysis of the present study are chosen by a filter (74). The present study is then given a dementia score (84) as a diagnostic feature vector that indicates to a clinician the type and severity of the ailment based on the analysis. The scanner (10) can produce PET or other metabolic and MR images for diagnosis. The MR can be used to measure blood flow rate into the brain. From the blood flow rate and the metabolic image, tracer, e.g. FDG, uptake maps can be generated for use in the automated diagnoses.

摘要翻译： 扫描仪（10）用于提供自动诊断神经变性疾病如阿尔茨海默病的图像。 将图像（90）注册到模板（78）。 对已经注册到包含在知识维护引擎（70）中的模板的参考图像数据（76,80）进行对准的图像的分析（60），用于类似的低强度模式，其将指示（在 FDG示踪剂的情况）降低了脑中的葡萄糖摄取。 用于本研究分析的最合适的参考图像由滤波器（74）选择。 然后，本研究给予痴呆评分（84）作为诊断特征向量，其基于分析向临床医生指示疾病的类型和严重程度。 扫描仪（10）可以产生PET或其他代谢和MR图像进行诊断。 MR可用于测量进入脑部的血液流量。 从血流速度和代谢图像，示踪剂，例如， 可以生成FDG，摄影图可用于自动诊断。

公开(公告)号：US10373375B2

公开(公告)日：2019-08-06

申请号：US14007698

申请日：2012-03-30

申请人： Fabian Wenzel ,  Roel Truyen ,  Jean-Pierre Franciscus Alexander Maria Ermes ,  Johan Michiel Den Harder

发明人： Fabian Wenzel ,  Roel Truyen ,  Jean-Pierre Franciscus Alexander Maria Ermes ,  Johan Michiel Den Harder

IPC分类号： G06T19/00 ,  G06T15/20 ,  G06F1/16 ,  G06F3/0481 ,  H04N13/388 ,  H04N13/398

摘要： Image processing system 100 for enabling a user to navigate through image data having at least three spatial dimensions by displaying views 155 of the image data, the image processing system comprising an image device 110 comprising a display 130 for displaying the views of the image data and an orientation sensor 120 for measuring an orientation of the image device with respect to a reference orientation for providing rotation data 125 indicative of a device rotation of the image device, means 140 for establishing a center of rotation in the image data, and an image processor 150 for establishing the views of the image data in relation to the device rotation by, for establishing a current view, (i) receiving the rotation data from the orientation sensor, (ii) establishing a view rotation in relation to the device rotation, and (iii) establishing the current view in dependence on the view rotation around the center of rotation with respect to a reference view.

公开(公告)号：US20130227052A1

公开(公告)日：2013-08-29

申请号：US13882601

申请日：2011-10-27

申请人： Fabian Wenzel ,  Thomas Netsch ,  Sebastian Peter Michael Dries

发明人： Fabian Wenzel ,  Thomas Netsch ,  Sebastian Peter Michael Dries

IPC分类号： H04L29/08 ,  G06T19/00

CPC分类号： H04L67/1097 ,  G06T19/003

摘要： Cache controller (120) for use in a system (180) comprising an image client (100) and an image server (140), the image client enabling a user to navigate through image data having at least three spatial dimensions by displaying views of the image data that are obtained from the image server in dependence on navigation requests of the user, and the cache controller comprising a processor (122) configured for obtaining content data indicative of a content shown in a current view of the image client (100), the current view representing a first viewpoint in the three spatial dimensions of the image data, the processor being further configured for predicting a view request of the image client in dependence on the content data, the view request corresponding to a view representing a second viewpoint in the three spatial dimensions of the image data, and a communication means (124) for obtaining the view from the image server in dependence on the view request, and for caching the view in a cache (130).

摘要翻译： 用于在包括图像客户机（100）和图像服务器（140）的系统（180）中使用的高速缓存控制器（120），所述图像客户端使得用户能够通过显示所述图像客户端的视图来导航具有至少三个空间维度的图像数据 图像数据，其根据用户的导航请求从图像服务器获得，并且所述高速缓存控制器包括被配置用于获取指示所述图像客户端（100）的当前视图中显示的内容的内容数据的处理器（122） 所述当前视图表示所述图像数据的三个空间维度中的第一视点，所述处理器还被配置为根据所述内容数据来预测所述图像客户端的视图请求，所述视图请求对应于表示第二视点的视图 图像数据的三个空间维度，以及用于根据视图请求从图像服务器获得视图的通信装置（124），以及用于将视图缓存在ca （130）。

公开(公告)号：US20100152577A1

公开(公告)日：2010-06-17

申请号：US12529195

申请日：2008-02-14

申请人： Stewart M. Young ,  Michael Kuhn ,  Fabian Wenzel ,  Ingwer C. Carlsen ,  Kirsten Meetz ,  Ralph Bucheri

发明人： Stewart M. Young ,  Michael Kuhn ,  Fabian Wenzel ,  Ingwer C. Carlsen ,  Kirsten Meetz ,  Ralph Bucheri

IPC分类号： A61B6/00 ,  G06K9/62

CPC分类号： A61B6/5247 ,  A61B5/0035 ,  A61B5/055 ,  A61B5/4088 ,  A61B6/037 ,  A61B6/507

摘要： A scanner (10) is used to provide images for automated diagnoses of neurodegenerative diseases, such as Alzheimers disease. The images are registered (90) to a template (78). The aligned image is analyzed (60) in relation to reference image data (76, 80) which has been registered to the template which is contained in a knowledge maintenance engine (70) for similar patterns of hypo-intensity that would indicate (in the case of an FDG tracer) reduced glucose uptake in the brain. The most appropriate reference images for the analysis of the present study are chosen by a filter (74). The present study is then given a dementia score (84) as a diagnostic feature vector that indicates to a clinician the type and severity of the ailment based on the analysis. The scanner (10) can produce PET or other metabolic and MR images for diagnosis. The MR can be used to measure blood flow rate into the brain. From the blood flow rate and the metabolic image, tracer, e.g. FDG, uptake maps can be generated for use in the automated diagnoses.

摘要翻译： 扫描仪（10）用于提供自动诊断神经变性疾病如阿尔茨海默病的图像。 将图像（90）注册到模板（78）。 对已经注册到包含在知识维护引擎（70）中的模板的参考图像数据（76,80）进行对准的图像的分析（60），用于类似的低强度模式，其将指示（在 FDG示踪剂的情况）降低了脑中的葡萄糖摄取。 用于本研究分析的最合适的参考图像由滤波器（74）选择。 然后，本研究给予痴呆评分（84）作为诊断特征向量，其基于分析向临床医生指示疾病的类型和严重程度。 扫描仪（10）可以产生PET或其他代谢和MR图像进行诊断。 MR可用于测量进入脑部的血液流量。 从血流速度和代谢图像，示踪剂，例如， 可以生成FDG，摄影图可用于自动诊断。

公开(公告)号：US09514575B2

公开(公告)日：2016-12-06

申请号：US13825824

申请日：2011-09-23

申请人： Sebastian Peter Michael Dries ,  Fabian Wenzel ,  Thomas Netsch

发明人： Sebastian Peter Michael Dries ,  Fabian Wenzel ,  Thomas Netsch

IPC分类号： G06T19/20 ,  G06T19/00

CPC分类号： G06T19/20 ,  G06T19/00 ,  G06T2219/004 ,  G06T2219/008

摘要： A system (100) for displaying a multi-dimensional image and an annotation located therein, the system comprising receiving means (110) for receiving: the multi-dimensional image, the annotation, and representation data associated with the annotation, the representation data being indicative of a preferred representation of the multi-dimensional image and the annotation located therein; display means (130) for displaying an initial representation (300) of the multi-dimensional image and the annotation located therein; input means (120) for enabling a user to provide a visualization request when the initial representation shows at least a first part (310) of the annotation; and the display means (130) being arranged for, after receiving the visualization request, displaying the preferred representation (400) of the multi-dimensional image and the annotation located therein in accordance with the representation data, the preferred representation showing at least a second part (410) of the annotation, the second part being different from the first part.

摘要翻译： 一种用于显示位于其中的多维图像和注释的系统（100），所述系统包括接收装置（110），用于接收：所述多维图像，所述注释和与所述注释相关联的表示数据，所述表示数据是 指示多维图像和位于其中的注释的优选表示; 显示装置（130），用于显示多维图像的初始表示（300）和位于其中的注释; 输入装置（120），用于当所述初始表示显示至少所述注释的第一部分（310）时，使用户能够提供可视化请求; 并且所述显示装置（130）被布置用于在接收到所述可视化请求之后，根据所述表示数据显示所述多维图像和位于其中的注释的优选表示（400），所述优选表示显示至少第二 注释的部分（410），第二部分与第一部分不同。

公开(公告)号：US10015250B2

公开(公告)日：2018-07-03

申请号：US13882601

申请日：2011-10-27

申请人： Fabian Wenzel ,  Thomas Netsch ,  Sebastian Peter Michael Dries

发明人： Fabian Wenzel ,  Thomas Netsch ,  Sebastian Peter Michael Dries

IPC分类号： G06F15/167 ,  H04L29/08 ,  G06T19/00

CPC分类号： H04L67/1097 ,  G06T19/003

摘要： Cache controller (120) for use in a system (180) comprising an image client (100) and an image server (140), the image client enabling a user to navigate through image data having at least three spatial dimensions by displaying views of the image data that are obtained from the image server in dependence on navigation requests of the user, and the cache controller comprising a processor (122) configured for obtaining content data indicative of a content shown in a current view of the image client (100), the current view representing a first viewpoint in the three spatial dimensions of the image data, the processor being further configured for predicting a view request of the image client in dependence on the content data, the view request corresponding to a view representing a second viewpoint in the three spatial dimensions of the image data, and a communication means (124) for obtaining the view from the image server in dependence on the view request, and for caching the view in a cache (130).

公开(公告)号：US20140022242A1

公开(公告)日：2014-01-23

申请号：US14007698

申请日：2012-03-30

申请人： Fabian Wenzel ,  Roel Truyen ,  Jean-Pierre Franciscus Alexander Maria Ermes ,  Johan Michiel Den Harder

发明人： Fabian Wenzel ,  Roel Truyen ,  Jean-Pierre Franciscus Alexander Maria Ermes ,  Johan Michiel Den Harder

IPC分类号： G06T19/00

CPC分类号： G06T19/003 ,  G06F1/1694 ,  G06F3/04815 ,  G06F2200/1637 ,  G06F2203/04806 ,  G06T15/20 ,  H04N13/349 ,  H04N13/388 ,  H04N13/398

摘要： Image processing system 100 for enabling a user to navigate through image data having at least three spatial dimensions by displaying views 155 of the image data, the image processing system comprising an image device 110 comprising a display 130 for displaying the views of the image data and an orientation sensor 120 for measuring an orientation of the image device with respect to a reference orientation for providing rotation data 125 indicative of a device rotation of the image device, means 140 forN establishing a center of rotation in the image data, and an image processor 150 for establishing the views of the image data in relation to the device rotation by, for establishing a current view, (i) receiving the rotation data from the orientation sensor, (ii) establishing a view rotation in relation to the device rotation, and (iii) establishing the current view in dependence on the view rotation around the center of rotation with respect to a reference view.

摘要翻译： 图像处理系统100，用于使用户能够通过显示图像数据的视图155导航具有至少三个空间维度的图像数据，该图像处理系统包括图像装置110，该图像装置110包括用于显示图像数据的视图的显示器130和 用于测量图像装置相对于参考方向的取向的方向传感器120，用于提供指示图像装置的装置旋转的旋转数据125，N在图像数据中建立旋转中心的装置140和图像 处理器150，用于通过用于建立当前视图来建立相对于设备旋转的图像数据的视图，（i）从定向传感器接收旋转数据，（ii）建立与设备旋转相关的视图旋转， 并且（iii）根据相对于参考视图围绕旋转中心的视图旋转来建立当前视图。

公开(公告)号：US20130187911A1

公开(公告)日：2013-07-25

申请号：US13825824

申请日：2011-09-23

申请人： Sebastian Peter Michael Dries ,  Fabian Wenzel ,  Thomas Netsch

发明人： Sebastian Peter Michael Dries ,  Fabian Wenzel ,  Thomas Netsch

IPC分类号： G06T19/20

CPC分类号： G06T19/20 ,  G06T19/00 ,  G06T2219/004 ,  G06T2219/008

摘要： A system (100) for displaying a multi-dimensional image and an annotation located therein, the system comprising receiving means (110) for receiving: the multi-dimensional image, the annotation, and representation data associated with the annotation, the representation data being indicative of a preferred representation of the multi-dimensional image and the annotation located therein; display means (130) for displaying an initial representation (300) of the multi-dimensional image and the annotation located therein; input means (120) for enabling a user to provide a visualization request when the initial representation shows at least a first part (310) of the annotation; and the display means (130) being arranged for, after receiving the visualization request, displaying the preferred representation (400) of the multi-dimensional image and the annotation located therein in accordance with the representation data, the preferred representation showing at least a second part (410) of the annotation, the second part being different from the first part.

摘要翻译： 一种用于显示位于其中的多维图像和注释的系统（100），所述系统包括接收装置（110），用于接收：所述多维图像，所述注释和与所述注释相关联的表示数据，所述表示数据是 指示多维图像和位于其中的注释的优选表示; 显示装置（130），用于显示多维图像的初始表示（300）和位于其中的注释; 输入装置（120），用于当所述初始表示显示至少所述注释的第一部分（310）时，使用户能够提供可视化请求; 并且所述显示装置（130）被布置用于在接收到所述可视化请求之后，根据所述表示数据显示所述多维图像和位于其中的注释的优选表示（400），所述优选表示显示至少第二 注释的部分（410），第二部分与第一部分不同。