公开(公告)号：US10219690B2

公开(公告)日：2019-03-05

申请号：US13420490

申请日：2012-03-14

申请人： Fabrice Manns ,  Manuel Bacci ,  David Borja ,  Stephanie Delgado ,  Jean-Marie Parel ,  Arthur Ho ,  Richard Allen Shelby ,  Lutz Andersohn ,  Andres Bernal

发明人： Fabrice Manns ,  Manuel Bacci ,  David Borja ,  Stephanie Delgado ,  Jean-Marie Parel ,  Arthur Ho ,  Richard Allen Shelby ,  Lutz Andersohn ,  Andres Bernal

IPC分类号： A61B3/10 ,  A61B3/103 ,  A61B3/107

摘要： An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.

公开(公告)号：US20120238904A1

公开(公告)日：2012-09-20

申请号：US13420490

申请日：2012-03-14

申请人： Fabrice Manns ,  Manuel Bacci ,  David Borja ,  Stephanie Delgado ,  Jean-Marie Parel ,  Arthur Ho ,  Richard Allen Shelby ,  Lutz Andersohn ,  Andres Bernal

发明人： Fabrice Manns ,  Manuel Bacci ,  David Borja ,  Stephanie Delgado ,  Jean-Marie Parel ,  Arthur Ho ,  Richard Allen Shelby ,  Lutz Andersohn ,  Andres Bernal

IPC分类号： A61B3/103

CPC分类号： A61B3/1015 ,  A61B3/103 ,  A61B3/107

摘要： An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.

摘要翻译： 描述了一种眼科折射仪，其通过将用于折射器的传感器系统的参考平面定位在角膜前方来提供球面光焦度和屈光不正之间的非线性关系。 折射器可以具有使其能够安装在手术显微镜上的工作距离和动态范围。 还描述了使用误差最小化，线性回归和傅里叶变换分析来分析眼科折射仪的输出的计算方法。

公开(公告)号：US07060095B2

公开(公告)日：2006-06-13

申请号：US10275496

申请日：2001-05-08

申请人： Arthur Ho ,  Paul Erickson ,  Fabrice Manns ,  Jean-Marie Parel

发明人： Arthur Ho ,  Paul Erickson ,  Fabrice Manns ,  Jean-Marie Parel

IPC分类号： A61F2/14

CPC分类号： A61F2/1616 ,  A61F2/1664 ,  Y10S623/905

摘要： The present invention is directed to a supplemental endo capsular lens (SECL) and the method of inserting and embedding the SECL within either a gel or polymer, inside the capsule of the crystalline lens, during phaco-ersatz or similar surgical procedures in order to supplement the refractive power of the eye with a view to (1) correcting ametropia while (2) maintaining a useable amplitude of accommodation.

公开(公告)号：US20120101375A1

公开(公告)日：2012-04-26

申请号：US13289709

申请日：2011-11-04

申请人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

发明人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

IPC分类号： A61B6/00

CPC分类号： A61N5/0601 ,  A61B5/015 ,  A61B6/583 ,  A61B2017/00084 ,  A61B2018/2005

摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed through the volume, generating a first image signal from the portions of the first beam detected, applying heat to at least a localized region of tissue within the volume after the illuminating and detecting, illuminating the volume with a second beam of X-rays, detecting portions of the second beam that passed through the volume during the illuminating with the second beam, generating a second image signal from the portions of the second beam detected, and generating a difference image signal based upon a comparison of the first and second image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume due to the application of heat.

摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，其利用第一射线束X射线照射一定体积的组织，检测穿过该体积的第一束的部分，从第一束的部分产生第一图像信号 检测到光束，在照射和检测之后，将热量施加到体积内的组织的至少局部区域，用第二射线束照射体积，检测在照射期间通过体积的第二束的部分， 第二光束，从所检测的第二光束的部分产生第二图像信号，并且基于第一和第二图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供体积内组织的局部区域的X射线衰减变化的信息。

公开(公告)号：US08099147B2

公开(公告)日：2012-01-17

申请号：US12081278

申请日：2008-04-14

申请人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

发明人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

IPC分类号： A61B5/00

CPC分类号： A61N5/0601 ,  A61B5/015 ,  A61B6/583 ,  A61B2017/00084 ,  A61B2018/2005

摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays that passed through the volume of tissue, generating a first X-ray image signal from the portions of X10 rays of the first beam detected, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays that passed through the volume of tissue during the illuminating with the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume of tissue due to the application of heat.

摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，用第一束X射线照射一定体积的组织，检测穿过组织体积的X射线的第一束束的部分，产生第一X 检测到的来自第一光束的X10射线的部分的图像信号，在照射之后并且在检测之后，将热量施加到组织体内的组织的至少局部区域，并用第二光束X照射组织的体积 检测在用第二光束X射线照射期间通过组织体积的第二X射线束的部分，从第二X射线的X射线的部分产生第二X射线图像信号 并且基于第一和第二X射线图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供组织体内的组织的局部区域的X射线衰减的变化信息。

公开(公告)号：US06684097B1

公开(公告)日：2004-01-27

申请号：US09556958

申请日：2000-04-21

申请人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

发明人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

IPC分类号： A61B500

CPC分类号： A61N5/0601 ,  A61B5/015 ,  A61B6/583 ,  A61B2017/00084 ,  A61B2018/2005

摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam of X-rays, generating a first X-ray image signal from the detected X-rays of the first beam, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume of tissue due to the application of heat.

摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，其利用第一X射线束照射一定体积的组织，检测第一X射线束的部分，从检测到的X生成第一X射线图像信号 - 第一光束的阵列，在照射之后并且在检测之后，将热量施加到组织体内的组织的至少局部区域，用第二光束X射线照射组织的体积，检测第二束的部分 从所检测的第二光束的X射线的部分生成第二X射线图像信号，并且基于第一和第二X射线图像信号的比较来生成差分图像信号。 差分图像信号由于施加热量而提供组织体内的组织的局部区域的X射线衰减的变化信息。

公开(公告)号：US08974059B2

公开(公告)日：2015-03-10

申请号：US13132748

申请日：2009-12-02

申请人： Omer Kocaoglu ,  Stephen Uhlhorn ,  Eleut Hernandez ,  Vittorio Porciatti ,  Jean-Marie Parel ,  Fabrice Manns

发明人： Omer Kocaoglu ,  Stephen Uhlhorn ,  Eleut Hernandez ,  Vittorio Porciatti ,  Jean-Marie Parel ,  Fabrice Manns

IPC分类号： A61B3/14 ,  A61B3/10 ,  A61B19/00 ,  A61F9/008

CPC分类号： A61B3/102 ,  A61B2090/3735 ,  A61F9/008 ,  A61F2009/00863

摘要： A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included coupled to the base element. An OCT imaging apparatus is also included coupled to the base element. An X-Y scanner is also included coupled to the base element in communication with the OCT imaging apparatus.

摘要翻译： 一种小型动物成像系统，包括基座元件和耦合到所述基座元件的照相机，所述相机的尺寸被设计成对小动物的眼睛进行成像。 发光二极管还包括耦合到基本元件。 还包括耦合到基本元件的OCT成像设备。 X-Y扫描器还包括与OCT成像设备连接的基座元件。

公开(公告)号：US08606346B2

公开(公告)日：2013-12-10

申请号：US13289709

申请日：2011-11-04

申请人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

发明人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

IPC分类号： A61B5/00

CPC分类号： A61N5/0601 ,  A61B5/015 ,  A61B6/583 ,  A61B2017/00084 ,  A61B2018/2005

摘要： A method of thermally inducing and monitoring changes to localized regions of tissue by illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed through the volume, generating a first image signal from the portions of the first beam detected, applying heat to at least a localized region of tissue within the volume after the illuminating and detecting, illuminating the volume with a second beam of X-rays, detecting portions of the second beam that passed through the volume during the illuminating with the second beam, generating a second image signal from the portions of the second beam detected, and generating a difference image signal based upon a comparison of the first and second image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume due to the application of heat.

摘要翻译： 一种通过用第一束X射线照射一定体积的组织来热诱导和监测对组织的局部区域的变化的方法，检测通过该体积的第一束的部分，从该部分中产生第一图像信号 检测到第一光束，在照射和检测之后，将热量施加到体积内的组织的至少局部区域，用第二射线束照射体积，检测在照射期间通过体积的第二光束的部分， 第二光束，从所检测的第二光束的部分产生第二图像信号，并且基于第一和第二图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供体积内组织的局部区域的X射线衰减变化的信息。

公开(公告)号：US20090052610A1

公开(公告)日：2009-02-26

申请号：US12081278

申请日：2008-04-14

申请人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

发明人： Jean-Marie Parel ,  Fabrice Manns ,  David S. Robinson ,  Peter Milne ,  David B. Denham ,  Xochitl Gonzalez-Cirre

IPC分类号： A61B6/00 ,  A61B18/04

CPC分类号： A61N5/0601 ,  A61B5/015 ,  A61B6/583 ,  A61B2017/00084 ,  A61B2018/2005

摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays that passed through the volume of tissue, generating a first X-ray image signal from the portions of X10 rays of the first beam detected, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays that passed through the volume of tissue during the illuminating with the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume of tissue due to the application of heat.

摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，用第一束X射线照射一定体积的组织，检测穿过组织体积的X射线的第一束束的部分，产生第一X 检测到的来自第一光束的X10射线的部分的图像信号，在照射之后并且在检测之后，将热量施加到组织体内的组织的至少局部区域，并用第二光束X照射组织的体积 检测在用第二光束X射线照射期间通过组织体积的第二X射线束的部分，从第二X射线的X射线的部分产生第二X射线图像信号 并且基于第一和第二X射线图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供组织体内的组织的局部区域的X射线衰减的变化信息。

公开(公告)号：US06640121B1

公开(公告)日：2003-10-28

申请号：US09635395

申请日：2000-08-10

申请人： Fred Telischi ,  Ozcan Ozdamar ,  Jean-Marie Parel ,  Fabrice Manns

发明人： Fred Telischi ,  Ozcan Ozdamar ,  Jean-Marie Parel ,  Fabrice Manns

IPC分类号： A61B504

CPC分类号： A61B5/6817 ,  A61B1/12 ,  A61B1/227 ,  A61B5/0261 ,  A61B5/04001 ,  A61B5/042 ,  A61B5/121 ,  A61B5/4041 ,  A61B5/4047 ,  A61B18/20 ,  A61B2018/00702 ,  A61B2018/0088

摘要： A microprobe useful for assessing auditory function by enabling clinical and intraoperative measurements of blood flow, particularly cochlear blood flow and neural compound action potentials, particularly of the auditory nerve (cranial nerve VIII) is disclosed. In addition, a monitoring system containing this microprobe and a method of using the microprobe are described.

摘要翻译： 公开了一种用于评估听觉功能的微探针，其能够进行血流的临床和术中测量，特别是耳蜗血流和神经复合动作电位，特别是听觉神经（颅神经VIII）的测量。 此外，描述了包含该微探针的监视系统以及使用该微探针的方法。