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公开(公告)号：US20080220989A1
公开(公告)日：2008-09-11
申请号：US11864164
申请日：2007-09-28
申请人： Fan Gang Tseng , Hsin Yi Hsieh , Chun Lung Wu
发明人： Fan Gang Tseng , Hsin Yi Hsieh , Chun Lung Wu
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , C40B80/00
摘要： A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first self-assembled monolayer by micro-titration technique. After the bonding reaction between the first biomedical molecular point and the first self-assembled monolayer, a second self-assembled monolayer is deposited on the surface of the first self-assembled monolayer by evaporation. The second self-assembled monolayer attached on the plurality of first biomedical molecular dots and the first self-assembled monolayer not bonded to the substrate are removed, so that the first biomedical molecular dots immobilized on the first self-assembled monolayer are exposed. Finally, a second biomedical molecular layer is immobilized on the exposed portions of the first biomedical molecular dots.
摘要翻译： 提供一种制造生物芯片的方法。 首先，将第一自组装单层涂覆在基材上。 接下来，通过微滴定技术在第一自组装单层上形成多个第一生物医学分子点。 在第一生物医学分子点和第一自组装单层之间的结合反应之后，第二自组装单层通过蒸发沉积在第一自组装单层的表面上。 去除附着在多个第一生物医学分子点上的第二自组装单层和未结合到基底的第一自组装单层，使得固定在第一自组装单层上的第一生物医学分子点被暴露。 最后，将第二生物医学分子层固定在第一生物医学分子点的暴露部分上。
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公开(公告)号：US08802024B2
公开(公告)日：2014-08-12
申请号：US11864164
申请日：2007-09-28
申请人： Fan Gang Tseng , Hsin Yi Hsieh , Chun Lung Wu
发明人： Fan Gang Tseng , Hsin Yi Hsieh , Chun Lung Wu
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , C40B80/00
摘要： A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first self-assembled monolayer by micro-titration technique. After the bonding reaction between the first biomedical molecular point and the first self-assembled monolayer, a second self-assembled monolayer is deposited on the surface of the first self-assembled monolayer by evaporation. The second self-assembled monolayer attached on the plurality of first biomedical molecular dots and the first self-assembled monolayer not bonded to the substrate are removed, so that the first biomedical molecular dots immobilized on the first self-assembled monolayer are exposed. Finally, a second biomedical molecular layer is immobilized on the exposed portions of the first biomedical molecular dots.
摘要翻译： 提供一种制造生物芯片的方法。 首先，将第一自组装单层涂覆在基材上。 接下来，通过微滴定技术在第一自组装单层上形成多个第一生物医学分子点。 在第一生物医学分子点和第一自组装单层之间的结合反应之后，第二自组装单层通过蒸发沉积在第一自组装单层的表面上。 去除附着在多个第一生物医学分子点上的第二自组装单层和未结合到基底的第一自组装单层，使得固定在第一自组装单层上的第一生物医学分子点被暴露。 最后，将第二生物医学分子层固定在第一生物医学分子点的暴露部分上。
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