公开(公告)号：US08877283B2

公开(公告)日：2014-11-04

申请号：US13318918

申请日：2009-07-09

申请人： Fang Wu ,  Yi Huang ,  Lei Song ,  Xiaoguang Liu ,  Yanfeng Xiao ,  Jiamin Feng ,  Jiyong Chen

发明人： Fang Wu ,  Yi Huang ,  Lei Song ,  Xiaoguang Liu ,  Yanfeng Xiao ,  Jiamin Feng ,  Jiyong Chen

IPC分类号： A61L33/00 ,  A61L27/32 ,  C23C4/12 ,  C23C4/10 ,  A61L27/56

CPC分类号： A61L27/32 ,  A61L27/56 ,  C23C4/11 ,  C23C4/134

摘要： The present invention relates to a preparation method for porous hydroxyapatite coatings. In particular, it is a method of using suspension plasma spraying to prepare porous hydroxyapatite coatings, which belongs to the technical field of biomedical material preparations. The present invention added a pore-forming agent into the hydroxyapatite suspension with a solid content of 16%-45%. After full stirring, the feedstock materials for plasma spraying were transferred into the injection system, and injected into the high temperature area of the central plasma flame. Then, the feedstock materials made the heat exchange with the high plasma flame of plasma spraying gun. Then the sprayed raw materials were subjected to breakup and refinement of the droplets, solvent evaporation, the decomposition and gasification of the pore-forming agent and melting of feedstock materials. Finally, the porous hydroxyapatite coatings are directly deposited onto the substrate surfaces of the biomedical materials.

摘要翻译： 本发明涉及一种多孔羟基磷灰石涂料的制备方法。 特别是采用悬浮等离子喷涂法制备多孔羟基磷灰石涂层的方法，属于生物医药材料制备技术领域。 本发明在固体含量为16％-45％的羟基磷灰石悬浮液中加入成孔剂。 充分搅拌后，将用于等离子体喷涂的原料转移到注射系统中，并注入中心等离子体火焰的高温区域。 然后，原料与等离子体喷枪的高等离子体火焰进行热交换。 然后将喷雾的原料进行液滴的分解和精制，溶剂蒸发，造孔剂的分解和气化以及原料的熔化。 最后，将多孔羟基磷灰石涂层直接沉积在生物医学材料的基材表面上。

公开(公告)号：US20120052183A1

公开(公告)日：2012-03-01

申请号：US13318918

申请日：2009-07-09

申请人： Fang Wu ,  Yi Huang ,  Lei Song ,  Xiaoguang Liu ,  Yanfeng Xiao ,  Jiamin Feng ,  Jiyong Chen

发明人： Fang Wu ,  Yi Huang ,  Lei Song ,  Xiaoguang Liu ,  Yanfeng Xiao ,  Jiamin Feng ,  Jiyong Chen

IPC分类号： C23C4/12 ,  C23C4/18

CPC分类号： A61L27/32 ,  A61L27/56 ,  C23C4/11 ,  C23C4/134

摘要： The present invention relates to a preparation method for porous hydroxyapatite coatings. In particular, it is a method of using suspension plasma spraying to prepare porous hydroxyapatite coatings, which belongs to the technical field of biomedical material preparations. The present invention added a pore-forming agent into the hydroxyapatite suspension with a solid content of 16%-45%. After full stirring, the feedstock materials for plasma spraying were transferred into the injection system, and injected into the high temperature area of the central plasma flame. Then, the feedstock materials made the heat exchange with the high plasma flame of plasma spraying gun. Then the sprayed raw materials were subjected to breakup and refinement of the droplets, solvent evaporation, the decomposition and gasification of the pore-forming agent and melting of feedstock materials. Finally, the porous hydroxyapatite coatings are directly deposited onto the substrate surfaces of the biomedical materials.

摘要翻译： 本发明涉及一种多孔羟基磷灰石涂料的制备方法。 特别是采用悬浮等离子喷涂法制备多孔羟基磷灰石涂层的方法，属于生物医药材料制备技术领域。 本发明在固体含量为16％-45％的羟基磷灰石悬浮液中加入成孔剂。 充分搅拌后，将用于等离子体喷涂的原料转移到注射系统中，并注入中心等离子体火焰的高温区域。 然后，原料与等离子体喷枪的高等离子体火焰进行热交换。 然后将喷雾的原料进行液滴的分解和精制，溶剂蒸发，造孔剂的分解和气化以及原料的熔化。 最后，将多孔羟基磷灰石涂层直接沉积在生物医学材料的基材表面上。

公开(公告)号：US08852667B2

公开(公告)日：2014-10-07

申请号：US13318925

申请日：2009-07-10

申请人： Fang Wu ,  Yanfeng Xiao ,  Lei Song ,  Xiaoguang Liu ,  Yi Huang ,  Tao Huang ,  Jiamin Feng

发明人： Fang Wu ,  Yanfeng Xiao ,  Lei Song ,  Xiaoguang Liu ,  Yi Huang ,  Tao Huang ,  Jiamin Feng

IPC分类号： A61L33/00 ,  C23C18/12 ,  C23C4/12 ,  C03C1/00 ,  C03C4/00 ,  C03C3/112 ,  A61L27/32 ,  C03C3/062 ,  C03C3/097

CPC分类号： C23C4/121 ,  A61L27/32 ,  A61L2420/02 ,  C03C1/008 ,  C03C3/062 ,  C03C3/097 ,  C03C3/112 ,  C03C4/0007 ,  C23C4/123 ,  C23C18/1212 ,  C23C18/1245 ,  C23C18/1254 ,  C23C18/1258

摘要： The present invention belongs to the field of biomedical material, and is particularly related to a method of preparing bioactive glass coatings by liquid precursor thermal spray. The objective of the present invention is to overcome the shortcomings of the air plasma spraying where the powder feedstock preparation is complicated and time-consuming, and sol-gel or other wet chemistry method where the synthesized coating generally has thin coating thickness and with low production efficiency. Therefore, a new method is provided for preparation of bioactive glass coatings. In this method, organic and inorganic raw materials were first weighed in accordance with the chemical composition of bioactive glasses, and sol or suspension was prepared; then the sol or suspension was used as the feedstock for thermal spray, and was deposited on the biomedical materials substrate, at high temperature to form the bioactive glass coating. The invention possesses the following advantages: simple operation, less complicated procedures, synthesis with high efficiency, low production cost, suitable for industrial production, and so on. This method can be used to prepare bioactive glass coatings.

摘要翻译： 本发明属于生物医学材料领域，特别涉及通过液体前体热喷涂制备生物活性玻璃涂层的方法。 本发明的目的是克服粉末原料制备复杂和耗时的空气等离子体喷涂的缺点，以及合成涂层通常具有薄的涂层厚度和低生产量的溶胶 - 凝胶或其它湿法化学方法 效率。 因此，提供了用于制备生物活性玻璃涂层的新方法。 在该方法中，首先根据生物活性玻璃的化学成分称量有机和无机原料，制备溶胶或悬浮液; 然后将溶胶或悬浮液用作热喷涂的原料，并在高温下沉积在生物医学材料基材上以形成生物活性玻璃涂层。 本发明具有操作简单，程序复杂程度低，合成效率高，生产成本低，适合工业生产等优点。 该方法可用于制备生物活性玻璃涂层。

公开(公告)号：US20120058250A1

公开(公告)日：2012-03-08

申请号：US13318925

申请日：2009-07-10

申请人： Fang Wu ,  Yanfeng Xiao ,  Lei Song ,  Xiaoguang Liu ,  Yi Huang ,  Tao Huang ,  Jiamin Feng

发明人： Fang Wu ,  Yanfeng Xiao ,  Lei Song ,  Xiaoguang Liu ,  Yi Huang ,  Tao Huang ,  Jiamin Feng

IPC分类号： A61L27/30 ,  A61L27/32

CPC分类号： C23C4/121 ,  A61L27/32 ,  A61L2420/02 ,  C03C1/008 ,  C03C3/062 ,  C03C3/097 ,  C03C3/112 ,  C03C4/0007 ,  C23C4/123 ,  C23C18/1212 ,  C23C18/1245 ,  C23C18/1254 ,  C23C18/1258

摘要： The present invention belongs to the field of biomedical material, and is particularly related to a method of preparing bioactive glass coatings by liquid precursor thermal spray. The objective of the present invention is to overcome the shortcomings of the air plasma spraying where the powder feedstock preparation is complicated and time-consuming, and sol-gel or other wet chemistry method where the synthesized coating generally has thin coating thickness and with low production efficiency. Therefore, a new method is provided for preparation of bioactive glass coatings. In this method, organic and inorganic raw materials were first weighed in accordance with the chemical composition of bioactive glasses, and sol or suspension was prepared; then the sol or suspension was used as the feedstock for thermal spray, and was deposited on the biomedical materials substrate, at high temperature to form the bioactive glass coating. The invention possesses the following advantages: simple operation, less complicated procedures, synthesis with high efficiency, low production cost, suitable for industrial production, and so on. This method can be used to prepare bioactive glass coatings.

摘要翻译： 本发明属于生物医学材料领域，特别涉及通过液体前体热喷涂制备生物活性玻璃涂层的方法。 本发明的目的是克服粉末原料制备复杂和耗时的空气等离子体喷涂的缺点，以及合成涂层通常具有薄的涂层厚度和低生产量的溶胶 - 凝胶或其它湿法化学方法 效率。 因此，提供了用于制备生物活性玻璃涂层的新方法。 在该方法中，首先根据生物活性玻璃的化学成分称量有机和无机原料，制备溶胶或悬浮液; 然后将溶胶或悬浮液用作热喷涂的原料，并在高温下沉积在生物医学材料基材上以形成生物活性玻璃涂层。 本发明具有操作简单，程序复杂程度低，合成效率高，生产成本低，适合工业生产等优点。 该方法可用于制备生物活性玻璃涂层。