公开(公告)号：US20150219678A1

公开(公告)日：2015-08-06

申请号：US14412317

申请日：2012-07-04

申请人： Fangyang He ,  Caiwei Feng ,  Yuping Wan ,  Nianqin Xu ,  Xiaoqin Luo ,  Jing Feng ,  Guangcan Tao ,  Houmei Yu ,  Yong Li ,  Sheng Fu ,  Peng Wu ,  Haifeng Cui

发明人： Fangyang He ,  Caiwei Feng ,  Yuping Wan ,  Nianqin Xu ,  Xiaoqin Luo ,  Jing Feng ,  Guangcan Tao ,  Houmei Yu ,  Yong Li ,  Sheng Fu ,  Peng Wu ,  Haifeng Cui

IPC分类号： G01N33/94 ,  G01N33/577

CPC分类号： G01N33/94 ,  G01N33/577 ,  G01N2430/00

摘要： The present invention discloses an enzyme-linked immunosorbent assay kit for detecting dinitolmide and use thereof. The enzyme-linked immunosorbent assay kit of the present invention comprises dinitolmide antibody and coating antigen and enzyme conjugate; wherein, the dinitolmide antibody is dinitolmide monoclonal antibody or dinitolmide polyclonal antibody; when the coating antigen is the conjugate of dinitolmide hapten and carrier protein, the enzyme conjugate is enzyme-labeled secondary antibody, or enzyme-labeled specific anti-dinitolmide monoclonal or polyclonal antibody; when the coating antigen is dinitolmide antibody or secondary antibody, the enzyme conjugate is enzyme-labeled dinitolmide hapten. The enzyme-linked immunosorbent assay kit has a simple structure, and it is convenient for use, cheap and portable. Its detection is high effective, accurate, and convenient. It can be used for on-site monitoring and is suitable for qualitative and quantitative screenings of a great number of samples. And thus, it will play an important role in the detection of dinitolmide.

摘要翻译： 本发明公开了一种用于检测二胺类化合物的酶联免疫吸附测定试剂盒及其应用。 本发明的酶联免疫吸附测定试剂盒包含二胺体抗体和包被抗原和酶结合物; 其中，二胺类抗体为二氨基甲酸单克隆抗体或二糖醇多克隆抗体; 当包被抗原是二氨基半胱氨酸半抗原和载体蛋白的结合物时，酶缀合物是酶标记的二抗或酶标记的特异性抗二糖醇单克隆或多克隆抗体; 当包被抗原是二胺抗体或二抗时，酶缀合物是酶标记的二胺体半抗原。 酶联免疫吸附测定试剂盒结构简单，使用方便，便宜便携。 其检测效率高，准确，方便。 它可用于现场监测，适用于大量样品的定性和定量筛选。 因此，它将在二硝基苯胺的检测中发挥重要作用。

公开(公告)号：US10234470B2

公开(公告)日：2019-03-19

申请号：US14412317

申请日：2012-07-04

申请人： Fangyang He ,  Yuping Wan ,  Caiwei Feng ,  Xiaoqin Luo ,  Jing Feng ,  Haifeng Cui ,  Nianqin Xu ,  Liangliang Zhu ,  Yumei Liu ,  Fangfang Jia ,  Zhengmiao Zhao

发明人： Fangyang He ,  Yuping Wan ,  Caiwei Feng ,  Xiaoqin Luo ,  Jing Feng ,  Haifeng Cui ,  Nianqin Xu ,  Liangliang Zhu ,  Yumei Liu ,  Fangfang Jia ,  Zhengmiao Zhao

IPC分类号： G01N33/94 ,  G01N33/577

摘要： The present invention discloses an enzyme-linked immunosorbent assay kit for detecting dinitolmide and use thereof. The enzyme-linked immunosorbent assay kit of the present invention comprises dinitolmide antibody and coating antigen and enzyme conjugate; wherein, the dinitolmide antibody is dinitolmide monoclonal antibody or dinitolmide polyclonal antibody; when the coating antigen is the conjugate of dinitolmide hapten and carrier protein, the enzyme conjugate is enzyme-labeled secondary antibody, or enzyme-labeled specific anti-dinitolmide monoclonal or polyclonal antibody; when the coating antigen is dinitolmide antibody or secondary antibody, the enzyme conjugate is enzyme-labeled dinitolmide hapten. The enzyme-linked immunosorbent assay kit has a simple structure, and it is convenient for use, cheap and portable. Its detection is high effective, accurate, and convenient. It can be used for on-site monitoring and is suitable for qualitative and quantitative screenings of a great number of samples. And thus, it will play an important role in the detection of dinitolmide.

公开(公告)号：US07547779B2

公开(公告)日：2009-06-16

申请号：US10574676

申请日：2004-10-06

申请人： Dennis Lee ,  Robert A. Stavenger ,  Krista B. Goodman ,  Mark A. Hilfiker ,  Haifeng Cui ,  Andrew Q. Viet ,  Joseph P. Marino

发明人： Dennis Lee ,  Robert A. Stavenger ,  Krista B. Goodman ,  Mark A. Hilfiker ,  Haifeng Cui ,  Andrew Q. Viet ,  Joseph P. Marino

IPC分类号： C07D413/00 ,  C07D401/00 ,  C07D471/02 ,  C07D491/02

CPC分类号： C07D471/04

摘要： Novel inhibitors of Rho-kinases are disclosed.

摘要翻译： 公开了Rho激酶的新型抑制剂。

公开(公告)号：US07921034B2

公开(公告)日：2011-04-05

申请号：US11568853

申请日：2006-05-15

申请人： Deqiang Zhang ,  Xiangdong Wang ,  Haifeng Cui ,  Zhengjun Zhang ,  Chonghui Huang ,  Xiaoyi Dong

发明人： Deqiang Zhang ,  Xiangdong Wang ,  Haifeng Cui ,  Zhengjun Zhang ,  Chonghui Huang ,  Xiaoyi Dong

IPC分类号： G06Q40/00

CPC分类号： H04M3/42 ,  G06Q30/0241 ,  G06Q30/0277 ,  G06Q40/00 ,  H04M3/42017 ,  H04M3/4878

摘要： The present invention discloses an Advertisement Platform (ADP), including an ADP Switch Point (ADP-SP), a voice playing unit and a service logic supporting unit; wherein the ADP-SP connects a call from a calling LS or an MS and initiates an advertisement service call to the service logic supporting unit; upon receiving the advertisement service call from the ADP-SP, the service logic supporting unit returns advertisement service instruction to the ADP-SP after parsing the advertisement service call; upon receiving the advertisement service instruction returned by the service logic supporting unit, the ADP-SP instructs the voice playing unit to play a ring back tone which includes advertisement according to the advertisement service instruction and connects a voice channel used for the voice playing unit playing advertisement with the calling voice channel or the MS voice channel. The present invention also discloses a system and method for playing advertisement.

摘要翻译： 本发明公开了一种广告平台（ADP），包括ADP交换点（ADP-SP），语音播放单元和业务逻辑支持单元; 其中所述ADP-SP连接来自主叫LS或MS的呼叫，并向所述业务逻辑支持单元发起广告业务呼叫; 在接收到来自ADP-SP的广告服务呼叫之后，服务逻辑支持单元在解析广告服务呼叫之后向ADP-SP返回广告服务指令; ADP-SP在接收到业务逻辑支持单元返回的广告业务指令后，指示语音播放单元根据广告业务指令播放包含广告的回铃音，并连接用于语音播放单元播放的语音信道 广播与主叫语音信道或MS语音信道。 本发明还公开了播放广告的系统和方法。

公开(公告)号：US20050197328A1

公开(公告)日：2005-09-08

申请号：US10508760

申请日：2003-03-21

申请人： Nicholas Bailey ,  Mark Bamford ,  Haifeng Cui ,  Stephen Garland ,  Krista Goodman ,  Mark Hilfiker ,  Dennis Lee ,  Terence Panchal ,  Robert Stavenger ,  David Wilson ,  Jason Witherington

发明人： Nicholas Bailey ,  Mark Bamford ,  Haifeng Cui ,  Stephen Garland ,  Krista Goodman ,  Mark Hilfiker ,  Dennis Lee ,  Terence Panchal ,  Robert Stavenger ,  David Wilson ,  Jason Witherington

IPC分类号： C07D473/36 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/52 ,  A61K31/5377 ,  A61P1/04 ,  A61P11/06 ,  A61P19/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  A61K31/551 ,  A61K31/498 ,  A61K31/503 ,  C07D473/14 ,  C07D487/02

CPC分类号： C07D471/04

摘要： A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

摘要翻译： 下式的化合物及其生理上可接受的盐和/或其N-氧化物，其中X 1是N或CR 3; X 2是N或CR 4; X 3是N或CR 5; X 4是N或CR 6。 条件是X 1，X 2，X 3和X 4中的至少一个但不多于两个， SUB>表示N. R 1是选自a，b，c或d的5-或6-元杂环基，其中X 5是选自 N或CR 7和X 6是选自O，S或NR 8的基团; 可以相同或不同的是选自N或CR 9的基团;其中X 1和X 3可以相同或不同。 X 9是选自O，S或NR 8和X 10的基团是N或CR 10; X 11，X 12和X 13可以相同或不同，选自基团N或CR 13， 11 其制备方法，含有它们的药物组合物及其在医药中的用途。

公开(公告)号：US07348339B2

公开(公告)日：2008-03-25

申请号：US10508760

申请日：2003-03-21

申请人： Nicholas Bailey ,  Mark James Bamford ,  Haifeng Cui ,  Stephen Garland ,  Krista B Goodman ,  Mark A Hilfiker ,  Dennis Lee ,  Terence Aaron Panchal ,  Robert A Stavenger ,  David Matthew Wilson ,  Jason Witherington

发明人： Nicholas Bailey ,  Mark James Bamford ,  Haifeng Cui ,  Stephen Garland ,  Krista B Goodman ,  Mark A Hilfiker ,  Dennis Lee ,  Terence Aaron Panchal ,  Robert A Stavenger ,  David Matthew Wilson ,  Jason Witherington

IPC分类号： A61K31/44 ,  A01N43/42 ,  C07D265/30 ,  C07D295/00 ,  C07D498/02

CPC分类号： C07D471/04

摘要： A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

摘要翻译： 下式的化合物及其生理上可接受的盐和/或其N-氧化物，其中X 1是N或CR 3; X 2是N或CR 4; X 3是N或CR 5; X 4是N或CR 6。 条件是X 1，X 2，X 3和X 4中的至少一个但不多于两个， SUB>表示N. R 1是选自a，b，c或d的5-或6-元杂环基，其中X 5是选自 N或CR 7和X 6是选自O，S或NR 8的基团; X 7和X 8可以相同或不同，是选自N或CR 9的基团。 X 9是选自O，S或NR 8和X 10的基团是N或CR 10; X 11，X 12和X 13可以相同或不同，并且选自N或C 11 ; 其制备方法，含有它们的药物组合物及其在医药中的用途。

公开(公告)号：US20080300969A1

公开(公告)日：2008-12-04

申请号：US11568853

申请日：2006-05-15

申请人： Deqiang Zhang ,  Xiangdong Wang ,  Haifeng Cui ,  Zhengjun Zhang ,  Chonghui Uang ,  Xiaoyi Dong

发明人： Deqiang Zhang ,  Xiangdong Wang ,  Haifeng Cui ,  Zhengjun Zhang ,  Chonghui Uang ,  Xiaoyi Dong

IPC分类号： G06Q30/00

CPC分类号： H04M3/42 ,  G06Q30/0241 ,  G06Q30/0277 ,  G06Q40/00 ,  H04M3/42017 ,  H04M3/4878

摘要： The present invention discloses an Advertisement Platform (ADP), including an ADP Switch Point (ADP-SP), a voice playing unit and a service logic supporting unit; wherein the ADP-SP connects a call from a calling LS or an MS and initiates an advertisement service call to the service logic supporting unit; upon receiving the advertisement service call from the ADP-SP, the service logic supporting unit returns advertisement service instruction to the ADP-SP after parsing the advertisement service call; upon receiving the advertisement service instruction returned by the service logic supporting unit, the ADP-SP instructs the voice playing unit to play a ring back tone which includes advertisement according to the advertisement service instruction and connects a voice channel used for the voice playing unit playing advertisement with the calling voice channel or the MS voice channel. The present invention also discloses a system and method for playing advertisement.

摘要翻译： 本发明公开了一种广告平台（ADP），包括ADP交换点（ADP-SP），语音播放单元和业务逻辑支持单元; 其中所述ADP-SP连接来自主叫LS或MS的呼叫，并向所述业务逻辑支持单元发起广告业务呼叫; 在接收到来自ADP-SP的广告服务呼叫之后，服务逻辑支持单元在解析广告服务呼叫之后向ADP-SP返回广告服务指令; ADP-SP在接收到业务逻辑支持单元返回的广告业务指令后，指示语音播放单元根据广告业务指示播放包含广告的回铃音，并连接用于播放声音的单元播放的语音信道 广播与主叫语音信道或MS语音信道。 本发明还公开了播放广告的系统和方法。

公开(公告)号：US20080234261A1

公开(公告)日：2008-09-25

申请号：US10574676

申请日：2004-10-06

申请人： Dennis Lee ,  Robert A. Stavenger ,  Krista A. Goodman ,  Mark A. Hilfiker ,  Haifeng Cui ,  Andrew Q. Viet ,  Joseph P. Marino

发明人： Dennis Lee ,  Robert A. Stavenger ,  Krista A. Goodman ,  Mark A. Hilfiker ,  Haifeng Cui ,  Andrew Q. Viet ,  Joseph P. Marino

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/437 ,  A61P9/00 ,  A61K31/496

CPC分类号： C07D471/04

摘要： Novel inhibitors of Rho-kinases are disclosed.

摘要翻译： 公开了Rho激酶的新型抑制剂。

公开(公告)号：US20070123561A1

公开(公告)日：2007-05-31

申请号：US10574675

申请日：2004-10-06

申请人： Dennis Lee ,  Robert Stavenger ,  Krista Goodman ,  Mark Hilfiker ,  Haifeng Cui ,  Joseph Marino

发明人： Dennis Lee ,  Robert Stavenger ,  Krista Goodman ,  Mark Hilfiker ,  Haifeng Cui ,  Joseph Marino

IPC分类号： C07D471/02 ,  A61K31/4745

CPC分类号： C07D471/04

摘要： Novel inhibitors of Rho-kinases are disclosed.

摘要翻译： 公开了Rho激酶的新型抑制剂。