公开(公告)号：US20250009924A1

公开(公告)日：2025-01-09

申请号：US18892456

申请日：2024-09-22

Applicant: Firmenich SA

Inventor： Matthew Rogers ,  Christian Margot ,  Christine Vuilleumier ,  Ben Smith ,  Sanja Fitzgerald ,  Maud Reiter ,  Stefano Nicolai

IPC: A61L9/01 ,  A61L9/012 ,  C07C35/32 ,  C07C43/168 ,  C07C43/174 ,  C11B9/00 ,  C11D3/00 ,  C11D3/20

Abstract: The present invention relates to the field of malodor counteraction. More particularly, it concerns malodor masking ingredient having an indane moiety (as defined in formula (I)), as well as malodor masking compositions comprising such ingredients.

公开(公告)号：US20220218860A1

公开(公告)日：2022-07-14

申请号：US17591250

申请日：2022-02-02

Applicant: FIRMENICH SA

Inventor： Matthew Rogers ,  Christian Margot ,  Christine Vuilleumier ,  Ben Smith ,  Sanja Fitzgerald ,  Maud Reiter ,  Stefano Nicolai

IPC: A61L9/01 ,  C11B9/00 ,  C11D3/00 ,  C11D3/20 ,  A61L9/012 ,  C07C43/174 ,  C07C35/32 ,  C07C43/168

Abstract: The present invention relates to the field of malodor counteraction. More particularly, it concerns malodor masking ingredient having an indane moiety (as defined in formula (I)), as well as malodor masking compositions comprising such ingredients.

公开(公告)号：US10913787B2

公开(公告)日：2021-02-09

申请号：US15580476

申请日：2016-06-09

Applicant: Firmenich SA

Inventor： Patrick Pfister ,  Matthew Rogers

IPC: C07K14/72 ,  G01N33/50

Abstract: Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.

公开(公告)号：US20240117001A1

公开(公告)日：2024-04-11

申请号：US18486417

申请日：2023-10-13

Applicant: FIRMENICH SA

Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

IPC: C07K14/705 ,  G01N33/50

CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

公开(公告)号：US11787847B2

公开(公告)日：2023-10-17

申请号：US16492115

申请日：2018-03-08

Applicant: FIRMENICH SA

Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

IPC: C07K14/705 ,  G01N33/50

CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

公开(公告)号：US12048783B2

公开(公告)日：2024-07-30

申请号：US16628120

申请日：2018-07-05

Applicant: FIRMENICH SA

Inventor： Monica Bandera ,  Sanja Fitzgerald ,  Yang Huang ,  Matthew Rogers ,  Ben Smith

IPC: A61L9/01 ,  A01N43/40 ,  A61K8/49 ,  A61Q15/00

CPC classification number: A61L9/01 ,  A01N43/40 ,  A61K8/4926 ,  A61Q15/00 ,  A61L2209/21

Abstract: The invention relates to malodor masking compositions and/or ingredients, methods for counteracting or masking malodors, and perfuming compositions having odor masking properties comprising 2, 4-dialkyl substituted pyridines for formula (I).

公开(公告)号：US11921105B2

公开(公告)日：2024-03-05

申请号：US16639307

申请日：2018-12-20

Applicant: FIRMENICH SA

Inventor： Patrick Pfister ,  Matthew Rogers ,  Lily Wu ,  Christian Margot

IPC: G01N33/50

CPC classification number: G01N33/502 ,  G01N2333/726

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to assays and methods for screening and identifying compositions and/or ingredients that intensify a subject's perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound.

公开(公告)号：US11744785B2

公开(公告)日：2023-09-05

申请号：US16760031

申请日：2018-11-21

Applicant: Firmenich SA

Inventor： Huey-Ling Kao ,  Stefan Alexander Ruider ,  Ben Smith ,  Gary Marr ,  Matthew Rogers ,  Mushhood Sheikh ,  Zhenan Wu ,  Patrick Pfister ,  Anthony Alexander Birkbeck ,  Julien Coulomb

IPC: A61Q15/00 ,  A61K8/33 ,  A61K8/31 ,  A61K8/34 ,  A61K8/368 ,  A61K8/41 ,  A61K8/49 ,  C11B9/00 ,  C11C5/00 ,  A61K8/35

CPC classification number: A61K8/33 ,  A61K8/31 ,  A61K8/347 ,  A61K8/35 ,  A61K8/368 ,  A61K8/41 ,  A61K8/4926 ,  A61K8/4973 ,  C11B9/0034 ,  C11B9/0042 ,  C11B9/0057 ,  C11C5/002

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

公开(公告)号：US11530366B2

公开(公告)日：2022-12-20

申请号：US16761795

申请日：2018-12-20

Applicant: Firmenich SA

Inventor： Patrick Pfister ,  Matthew Rogers ,  Jana Pika ,  Florian De Nanteuil ,  Nicholas O'Leary ,  Christie Delaura

IPC: C11B9/00 ,  A61K8/35

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subjects perception of musk compounds, methods for intensifying a subjects perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).

公开(公告)号：US20200002399A1

公开(公告)日：2020-01-02

申请号：US16492115

申请日：2018-03-08

Applicant: FIRMENICH SA

Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

IPC: C07K14/705 ,  G01N33/50

Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid N sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.