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    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS
    1.
    发明公开
    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS 审中-公开

    公开(公告)号：US20240117001A1

    公开(公告)日：2024-04-11

    申请号：US18486417

    申请日：2023-10-13

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

    IPC: C07K14/705 ,  G01N33/50

    CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

    Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

    Method of identifying malodor modulating compounds
    2.
    发明授权
    Method of identifying malodor modulating compounds 有权

    公开(公告)号：US11787847B2

    公开(公告)日：2023-10-17

    申请号：US16492115

    申请日：2018-03-08

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

    IPC: C07K14/705 ,  G01N33/50

    CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

    Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

    Use of volatile compounds to modulate the perception of floral muguet
    3.
    发明授权
    Use of volatile compounds to modulate the perception of floral muguet 有权

    公开(公告)号：US11951197B2

    公开(公告)日：2024-04-09

    申请号：US17294655

    申请日：2019-12-17

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Christie Delaura ,  Casey Trimmer ,  Lily Wu ,  Aleksey Dumer ,  Florian De Nanteuil

    IPC: A61K8/33 ,  A61Q13/00

    CPC classification number: A61K8/33 ,  A61Q13/00

    Abstract: Described herein are compositions and/or ingredients that increase a subject's perception of floral muguet compounds, methods for intensifying a subject's perception of floral muguet compounds, as well as perfumed articles or perfuming compositions including as an active ingredient, at least one compound selected from octanal; (E)-dec-2-enal, 2-phenylpropanal; (E)-but-2-enal; 3-methylbenzaldehyde; 3-(1,3-benzodioxol-5-yl)-2-methylpropanal; (±)-3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, (±)-4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, and mixtures thereof; heptanal, 4-Propan-2-ylbenzaldehyde; (3R)-3,7-dimethyloct-6-enal; (+)-(3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (+)-(3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, and mixtures thereof; hexanal; 2,6-dimethylhept-5-enal; benzaldehyde; 2-methyl-3-(4-methylphenyl)propanal; 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, and mixtures thereof; 4-ethylbenzaldehyde; 6-methoxy-2,6-dimethylheptanal; (E)-non-2-enal; and combinations thereof.

    Method of identifying musk compounds
    4.
    发明授权
    Method of identifying musk compounds 有权

    公开(公告)号：US10913787B2

    公开(公告)日：2021-02-09

    申请号：US15580476

    申请日：2016-06-09

    Applicant: Firmenich SA

    Inventor： Patrick Pfister ,  Matthew Rogers

    IPC: C07K14/72 ,  G01N33/50

    Abstract: Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.

    USE OF VOLATILE COMPOUNDS TO MODULATE THE PERCEPTION OF FLORAL MUGUET
    6.
    发明申请
    USE OF VOLATILE COMPOUNDS TO MODULATE THE PERCEPTION OF FLORAL MUGUET 有权

    公开(公告)号：US20220008302A1

    公开(公告)日：2022-01-13

    申请号：US17294655

    申请日：2019-12-17

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Christie Delaura ,  Casey Trimmer ,  Lily Wu ,  Aleksey Dumer ,  Florian De Nanteuil

    IPC: A61K8/33 ,  A61Q13/00

    Abstract: Described herein are compositions and/or ingredients that increase a subject's perception of floral muguet compounds, methods for intensifying a subject's perception of floral muguet compounds, as well as perfumed articles or perfuming compositions including as an active ingredient, at least one compound selected from octanal; (E)-dec-2-enal, 2-phenylpropanal; (E)-but-2-enal; 3-methylbenzaldehyde; 3-(1,3-benzodioxol-5-yl)-2-methylpropanal; (±)-3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, (±)-4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, and mixtures thereof; heptanal, 4-Propan-2-ylbenzaldehyde; (3R)-3,7-dimethyloct-6-enal; (+)-(3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (+)-(3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, and mixtures thereof; hexanal; 2,6-dimethylhept-5-enal; benzaldehyde; 2-methyl-3-(4-methylphenyl)propanal; 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, and mixtures thereof; 4-ethylbenzaldehyde; 6-methoxy-2,6-dimethylheptanal; (E)-non-2-enal; and combinations thereof.

    USE OF VOLATILE COMPOUNDS TO MODULATE THE PERCEPTION OF FLORAL MUGUET
    7.
    发明公开
    USE OF VOLATILE COMPOUNDS TO MODULATE THE PERCEPTION OF FLORAL MUGUET 审中-公开

    公开(公告)号：US20240238177A1

    公开(公告)日：2024-07-18

    申请号：US18606967

    申请日：2024-03-15

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Christie Delaura ,  Casey Trimmer ,  Lily Wu ,  Aleksey Dumer ,  Florian De Nanteuil

    IPC: A61K8/33 ,  A61Q13/00

    CPC classification number: A61K8/33 ,  A61Q13/00

    Abstract: Described herein are compositions and/or ingredients that increase a subject's perception of floral muguet compounds, methods for intensifying a subject's perception of floral muguet compounds, as well as perfumed articles or perfuming compositions including as an active ingredient, at least one compound selected from octanal; (E)-dec-2-enal, 2-phenylpropanal; (E)-but-2-enal; 3-methylbenzaldehyde; 3-(1,3-benzodioxol-5-yl)-2-methylpropanal; (±)-3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, (±)-4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, and mixtures thereof; heptanal, 4-Propan-2-ylbenzaldehyde; (3R)-3,7-dimethyloct-6-enal; (+)-(3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (+)-(3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, and mixtures thereof; hexanal; 2,6-dimethylhept-5-enal; benzaldehyde; 2-methyl-3-(4-methylphenyl)propanal; 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, and mixtures thereof; 4-ethylbenzaldehyde; 6-methoxy-2,6-dimethylheptanal; (E)-non-2-enal; and combinations thereof.

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