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Patent Agency Ranking
公开(公告)号：US10436698B2
公开(公告)日：2019-10-08
申请号：US16230570
申请日：2018-12-21
Applicant: Fluidigm Corporation
Inventor： Dmitry R. Bandura , Vladimir I. Baranov , Scott D. Tanner
Abstract: An analytical instrument has a sample introduction system for generating a stream of particles from a sample. An ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles. The instrument can be adapted to measure the amount of many different tags, for example at least five different tags, at the same time to facilitate multi-parametric analysis of cells and other particles.
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公开(公告)号：US20190195771A1
公开(公告)日：2019-06-27
申请号：US16230570
申请日：2018-12-21
Applicant: Fluidigm Corporation
Inventor： Dmitry R. Bandura , Vladimir I. Baranov , Scott D. Tanner
CPC classification number: G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
Abstract: An analytical instrument has a sample introduction system for generating a stream of particles from a sample. An ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles. The instrument can be adapted to measure the amount of many different tags, for example at least five different tags, at the same time to facilitate multi-parametric analysis of cells and other particles.
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公开(公告)号：US10180386B2
公开(公告)日：2019-01-15
申请号：US15888871
申请日：2018-02-05
Applicant: Fluidigm Corporation
Inventor： Dmitry R. Bandura , Vladimir I. Baranov , Scott D. Tanner
Abstract: A method for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. Particles or element tags associated with particles can be vaporized, atomized, and ionized, such as with an inductively coupled plasma device or a glow discharge device. The vaporized, atomized, and ionized particles or element tags can be analyzed using mass spectrometry, such as using a time of flight mass spectrometer or a magnetic sector mass spectrometer. The amount of at least one element in individual particles can be measured through mass analysis. The amount of many different tags, for example at least five different tags, can be measured at the same time to facilitate multi-parametric analysis of cells and other particles. The vaporized, atomized, and ionized particles or element tags can be pretreated in an ion pretreatment system to filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough.
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公开(公告)号：US20180195948A1
公开(公告)日：2018-07-12
申请号：US15888871
申请日：2018-02-05
Applicant: Fluidigm Corporation
Inventor： Dmitry R. Bandura , Vladimir I. Baranov , Scott D. Tanner
CPC classification number: G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
Abstract: A method for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. Particles or element tags associated with particles can be vaporized, atomized, and ionized, such as with an inductively coupled plasma device or a glow discharge device. The vaporized, atomized, and ionized particles or element tags can be analyzed using mass spectrometry, such as using a time of flight mass spectrometer or a magnetic sector mass spectrometer. The amount of at least one element in individual particles can be measured through mass analysis. The amount of many different tags, for example at least five different tags, can be measured at the same time to facilitate multi-parametric analysis of cells and other particles. The vaporized, atomized, and ionized particles or element tags can be pretreated in an ion pretreatment system to filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough.
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公开(公告)号：US20200240895A1
公开(公告)日：2020-07-30
申请号：US16844373
申请日：2020-04-09
Applicant: Fluidigm Corporation
Inventor： Dmitry R. Bandura , Vladimir I. Baranov , Scott D. Tanner
Abstract: An analytical instrument has a sample introduction system for generating a stream of particles from a sample. An ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles. The instrument can be adapted to measure the amount of many different tags, for example at least five different tags, at the same time to facilitate multi-parametric analysis of cells and other particles.
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