公开(公告)号：US20100144867A1

公开(公告)日：2010-06-10

申请号：US12520386

申请日：2007-12-19

申请人： Francis Barany ,  Yu-Wei Cheng ,  Philip Paty ,  Daniel Notterman

发明人： Francis Barany ,  Yu-Wei Cheng ,  Philip Paty ,  Daniel Notterman

IPC分类号： A61K31/27 ,  C12Q1/68 ,  A61K31/07 ,  A61K31/10

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/16

摘要： The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.

摘要翻译： 本发明涉及使用卵磷脂：视黄醇酰基转移酶（LRAT）基因启动子甲基化状态评估受试者的癌症状态的方法。 还公开了分析和定量LRAT基因启动子甲基化水平的方法。 本发明还涉及通过评估LRAT mRNA表达和LRAT蛋白表达来测定患有癌症的受试者的预后的方法。 还公开了癌症检测，诊断，预后和治疗方法。

公开(公告)号：US09090941B2

公开(公告)日：2015-07-28

申请号：US12520386

申请日：2007-12-19

申请人： Francis Barany ,  Yu-Wei Cheng ,  Philip Paty ,  Daniel Notterman

发明人： Francis Barany ,  Yu-Wei Cheng ,  Philip Paty ,  Daniel Notterman

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/16

摘要： The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.

摘要翻译： 本发明涉及使用卵磷脂：视黄醇酰基转移酶（LRAT）基因启动子甲基化状态评价受试者的癌症状态的方法。 还公开了分析和定量LRAT基因启动子甲基化水平的方法。 本发明还涉及通过评估LRAT mRNA表达和LRAT蛋白表达来测定患有癌症的受试者的预后的方法。 还公开了癌症检测，诊断，预后和治疗方法。

公开(公告)号：US20080306276A1

公开(公告)日：2008-12-11

申请号：US11760985

申请日：2007-06-11

申请人： Win-Long Chia ,  Yu-Wei Cheng

发明人： Win-Long Chia ,  Yu-Wei Cheng

IPC分类号： C07D213/02

CPC分类号： C07D213/84

摘要： The invention relates to a facile synthesis of a series of 2-(4′-alkoxyphenyl)-5-cyanopyridine liquid crystal compounds which are represented by the following formula (I): wherein CnH2n+1 is a linear alkyl group having 2-12 carbon atoms. The synthesis of the liquid crystalline 2-(4′-alkoxyphenyl)-5-cyanopyridine is completed in a two-step reaction. First, a Grignard reagent (such as 4-alkoxyphenylmagnesium bromide) is added to a 3-cyanopyridinium salt (such as N-phenyloxycarbonyl-3-cyanopyridinium chloride) to get a 1,2-dihydropyridine. Then, the 1,2-dihydropyridine is oxidized with o-chloronil to obtain the 2-(4′-alkoxyphenyl)-5-cyanopyridine.

摘要翻译： 本发明涉及一种由下式（I）表示的一系列2-（4'-烷氧基苯基）-5-氰基吡啶液晶化合物的简便合成：其中C n H 2n + 1是具有2-12个碳原子的直链烷基 碳原子。 液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成在两步反应中完成。 首先，向3-氰基吡啶鎓盐（如N-苯氧基羰基-3-氰基吡啶鎓氯化物）中加入格氏试剂（如4-烷氧基苯基溴化镁），得到1,2-二氢吡啶。 然后，用邻氯苯酚氧化1,2-二氢吡啶，得到2-（4'-烷氧基苯基）-5-氰基吡啶。

公开(公告)号：US08785115B2

公开(公告)日：2014-07-22

申请号：US13370226

申请日：2012-02-09

申请人： Hung-Yi Wu ,  Yuan-Chi Pai ,  Yu-Wei Cheng ,  Chang-Mao Wang

发明人： Hung-Yi Wu ,  Yuan-Chi Pai ,  Yu-Wei Cheng ,  Chang-Mao Wang

IPC分类号： G03F7/42

CPC分类号： H01L21/31133 ,  H01L21/32139 ,  H01L21/823842 ,  H01L21/823864

摘要： A photoresist removal method is described. A substrate having thereon a positive photoresist layer to be removed is provided. The positive photoresist layer is UV-exposed without using a photomask. A development liquid is used to remove the UV-exposed positive photoresist layer. The substrate as provided may further have thereon a sacrificial masking layer under the positive photoresist layer. The sacrificial masking layer is removed after the UV-exposed positive photoresist layer is removed.

摘要翻译： 描述光致抗蚀剂去除方法。 提供其上具有要去除的正性光致抗蚀剂层的基板。 正光致抗蚀剂层在不使用光掩模的情况下被UV曝光。 使用显影液来除去UV曝光的正性光致抗蚀剂层。 所提供的基底还可以在正光致抗蚀剂层下方具有牺牲掩模层。 在除去UV曝光的正性光致抗蚀剂层之后去除牺牲掩模层。

公开(公告)号：US20130210237A1

公开(公告)日：2013-08-15

申请号：US13370226

申请日：2012-02-09

申请人： Hung-Yi Wu ,  Yuan-Chi Pai ,  Yu-Wei Cheng ,  Chang-Mao Wang

发明人： Hung-Yi Wu ,  Yuan-Chi Pai ,  Yu-Wei Cheng ,  Chang-Mao Wang

IPC分类号： H01L21/306

CPC分类号： H01L21/31133 ,  H01L21/32139 ,  H01L21/823842 ,  H01L21/823864

摘要： A photoresist removal method is described. A substrate having thereon a positive photoresist layer to be removed is provided. The positive photoresist layer is UV-exposed without using a photomask. A development liquid is used to remove the UV-exposed positive photoresist layer. The substrate as provided may further have thereon a sacrificial masking layer under the positive photoresist layer. The sacrificial masking layer is removed after the UV-exposed positive photoresist layer is removed.

摘要翻译： 描述光致抗蚀剂去除方法。 提供其上具有要去除的正性光致抗蚀剂层的基板。 正光致抗蚀剂层在不使用光掩模的情况下被UV曝光。 使用显影液来除去UV曝光的正性光致抗蚀剂层。 所提供的基底还可以在正光致抗蚀剂层下方具有牺牲掩模层。 在除去UV曝光的正性光致抗蚀剂层之后去除牺牲掩模层。

公开(公告)号：US07872143B2

公开(公告)日：2011-01-18

申请号：US11760985

申请日：2007-06-11

申请人： Win-Long Chia ,  Yu-Wei Cheng

发明人： Win-Long Chia ,  Yu-Wei Cheng

IPC分类号： C07D213/85

CPC分类号： C07D213/84

摘要： The invention relates to a facile synthesis of a series of 2-(4′-alkoxyphenyl)-5-cyanopyridine liquid crystal compounds which are represented by the following formula (I): wherein CnH2n+1 is a linear alkyl group having 2-12 carbon atoms. The synthesis of the liquid crystalline 2-(4′-alkoxyphenyl)-5-cyanopyridine is completed in a two-step reaction. First, a Grignard reagent (such as 4-alkoxyphenylmagnesium bromide) is added to a 3-cyanopyridinium salt (such as N-phenyloxycarbonyl-3-cyanopyridinium chloride) to get a 1,2-dihydropyridine. Then, the 1,2-dihydropyridine is oxidized with o-chloronil to obtain the 2-(4′-alkoxyphenyl)-5-cyanopyridine.

摘要翻译： 本发明涉及一种由下式（I）表示的一系列2-（4'-烷氧基苯基）-5-氰基吡啶液晶化合物的简便合成：其中C n H 2n + 1是具有2-12个碳原子的直链烷基 碳原子。 液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成在两步反应中完成。 首先，向3-氰基吡啶鎓盐（如N-苯氧基羰基-3-氰基吡啶鎓氯化物）中加入格氏试剂（如4-烷氧基苯基溴化镁），得到1,2-二氢吡啶。 然后，用邻氯苯酚氧化1,2-二氢吡啶，得到2-（4'-烷氧基苯基）-5-氰基吡啶。