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公开(公告)号：US09670540B2
公开(公告)日：2017-06-06
申请号：US14234011
申请日：2012-07-23
申请人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
发明人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
CPC分类号： C12Q1/6874 , C12Q1/6806 , G01N33/585 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2563/131 , C12Q2565/543
摘要： The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
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2.发明授权Facile synthesis of a series of liquid crystalline 2-(4′-alkoxyphenyl)-5-cyanopyridines 有权一系列液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成公开(公告)号：US07872143B2
公开(公告)日：2011-01-18
申请号：US11760985
申请日：2007-06-11
申请人： Win-Long Chia , Yu-Wei Cheng
发明人： Win-Long Chia , Yu-Wei Cheng
IPC分类号： C07D213/85
CPC分类号： C07D213/84
摘要： The invention relates to a facile synthesis of a series of 2-(4′-alkoxyphenyl)-5-cyanopyridine liquid crystal compounds which are represented by the following formula (I): wherein CnH2n+1 is a linear alkyl group having 2-12 carbon atoms. The synthesis of the liquid crystalline 2-(4′-alkoxyphenyl)-5-cyanopyridine is completed in a two-step reaction. First, a Grignard reagent (such as 4-alkoxyphenylmagnesium bromide) is added to a 3-cyanopyridinium salt (such as N-phenyloxycarbonyl-3-cyanopyridinium chloride) to get a 1,2-dihydropyridine. Then, the 1,2-dihydropyridine is oxidized with o-chloronil to obtain the 2-(4′-alkoxyphenyl)-5-cyanopyridine.
摘要翻译： 本发明涉及一种由下式（I）表示的一系列2-（4'-烷氧基苯基）-5-氰基吡啶液晶化合物的简便合成：其中C n H 2n + 1是具有2-12个碳原子的直链烷基 碳原子。 液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成在两步反应中完成。 首先，向3-氰基吡啶鎓盐（如N-苯氧基羰基-3-氰基吡啶鎓氯化物）中加入格氏试剂（如4-烷氧基苯基溴化镁），得到1,2-二氢吡啶。 然后，用邻氯苯酚氧化1,2-二氢吡啶，得到2-（4'-烷氧基苯基）-5-氰基吡啶。
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3.发明授权Use of lecithin:retinol acyl transferase gene promoter methylation in evaluating the cancer state of subject 有权使用卵磷脂：视黄醇酰基转移酶基因启动子甲基化评估受试者的癌症状态公开(公告)号：US09090941B2
公开(公告)日：2015-07-28
申请号：US12520386
申请日：2007-12-19
申请人： Francis Barany , Yu-Wei Cheng , Philip Paty , Daniel Notterman
发明人： Francis Barany , Yu-Wei Cheng , Philip Paty , Daniel Notterman
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
摘要： The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.
摘要翻译： 本发明涉及使用卵磷脂：视黄醇酰基转移酶（LRAT）基因启动子甲基化状态评价受试者的癌症状态的方法。 还公开了分析和定量LRAT基因启动子甲基化水平的方法。 本发明还涉及通过评估LRAT mRNA表达和LRAT蛋白表达来测定患有癌症的受试者的预后的方法。 还公开了癌症检测，诊断，预后和治疗方法。
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公开(公告)号：US20150099642A1
公开(公告)日：2015-04-09
申请号：US14234011
申请日：2012-07-23
申请人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Malgorzata A. Witek , Daniel San-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
发明人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Malgorzata A. Witek , Daniel San-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6806 , G01N33/585 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2563/131 , C12Q2565/543
摘要： The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
摘要翻译： 本发明涉及用于捕获，扩增和鉴定样品中多个靶核苷酸序列中的一个或多个的方法。 本发明进一步涉及包括具有多个孔或柱的固体支持物和连接到孔或支柱上的多个寡核苷酸的装置。 本发明的其它方面涉及制造这种装置的方法。
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5.发明申请METHODS FOR IDENTIFYING GENES WHICH PREDICT DISEASE OUTCOME FOR PATIENTS WITH COLON CANCER 审中-公开识别患有结肠癌患者预防疾病的基因的方法公开(公告)号：US20110257034A1
公开(公告)日：2011-10-20
申请号：US13123689
申请日：2009-10-13
申请人： Francis Barany , Owen Parker , Manny D. Bacolod , Sarah F. Giardina , Yu-wei Cheng , Daniel A. Notterman , Gunter S. Schemmann , Philip B. Paty , Monib Zirvi
发明人： Francis Barany , Owen Parker , Manny D. Bacolod , Sarah F. Giardina , Yu-wei Cheng , Daniel A. Notterman , Gunter S. Schemmann , Philip B. Paty , Monib Zirvi
CPC分类号： G01N33/57419
摘要： Closures for containers and methods for using same are provided. In a general embodiment/the present disclosure provides a closure having a top portion (12), a bottom portion (14) and a side portion (16), an aperture (18) extending though the closure, a projection (20) extending from the closure and at least two rib members (36) on an interior of the projection. The projection may also include a cover (22). In another embodiment, a method for using a closure includes inserting a. spike member into a projection, piercing a membrane that hermetically seals a medical container, pushing rib members within the projection to center the spike member inserted into the projection, and tearing the membrane to create a vent hole in the membrane.
摘要翻译： 提供容器的封闭件和使用容器的方法。 在一般实施例中，本公开提供了一种具有顶部部分（12），底部部分（14）和侧部部分（16）的封闭件，通过封闭件延伸的孔口（18） 所述封闭件和所述突起的内部上的至少两个肋构件（36）。 突起还可以包括盖（22）。 在另一个实施例中，一种使用闭合件的方法包括： 突出部件突入，刺穿密封医疗容器的膜，推动突起内的肋构件以使插入突起中的钉构件居中，并撕裂膜以在隔膜中形成通气孔。
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公开(公告)号：US08785115B2
公开(公告)日：2014-07-22
申请号：US13370226
申请日：2012-02-09
申请人： Hung-Yi Wu , Yuan-Chi Pai , Yu-Wei Cheng , Chang-Mao Wang
发明人： Hung-Yi Wu , Yuan-Chi Pai , Yu-Wei Cheng , Chang-Mao Wang
IPC分类号： G03F7/42
CPC分类号： H01L21/31133 , H01L21/32139 , H01L21/823842 , H01L21/823864
摘要： A photoresist removal method is described. A substrate having thereon a positive photoresist layer to be removed is provided. The positive photoresist layer is UV-exposed without using a photomask. A development liquid is used to remove the UV-exposed positive photoresist layer. The substrate as provided may further have thereon a sacrificial masking layer under the positive photoresist layer. The sacrificial masking layer is removed after the UV-exposed positive photoresist layer is removed.
摘要翻译： 描述光致抗蚀剂去除方法。 提供其上具有要去除的正性光致抗蚀剂层的基板。 正光致抗蚀剂层在不使用光掩模的情况下被UV曝光。 使用显影液来除去UV曝光的正性光致抗蚀剂层。 所提供的基底还可以在正光致抗蚀剂层下方具有牺牲掩模层。 在除去UV曝光的正性光致抗蚀剂层之后去除牺牲掩模层。
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公开(公告)号：US20130210237A1
公开(公告)日：2013-08-15
申请号：US13370226
申请日：2012-02-09
申请人： Hung-Yi Wu , Yuan-Chi Pai , Yu-Wei Cheng , Chang-Mao Wang
发明人： Hung-Yi Wu , Yuan-Chi Pai , Yu-Wei Cheng , Chang-Mao Wang
IPC分类号： H01L21/306
CPC分类号： H01L21/31133 , H01L21/32139 , H01L21/823842 , H01L21/823864
摘要： A photoresist removal method is described. A substrate having thereon a positive photoresist layer to be removed is provided. The positive photoresist layer is UV-exposed without using a photomask. A development liquid is used to remove the UV-exposed positive photoresist layer. The substrate as provided may further have thereon a sacrificial masking layer under the positive photoresist layer. The sacrificial masking layer is removed after the UV-exposed positive photoresist layer is removed.
摘要翻译： 描述光致抗蚀剂去除方法。 提供其上具有要去除的正性光致抗蚀剂层的基板。 正光致抗蚀剂层在不使用光掩模的情况下被UV曝光。 使用显影液来除去UV曝光的正性光致抗蚀剂层。 所提供的基底还可以在正光致抗蚀剂层下方具有牺牲掩模层。 在除去UV曝光的正性光致抗蚀剂层之后去除牺牲掩模层。
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8.发明申请USE OF LECITHIN:RETINOL ACYL TRANSFERASE GENE PROMOTER METHYLATION IN EVALUATING THE CANCER STATE OF SUBJECT 有权LECITHIN的使用：用于评估患者癌症状态的催乳素ACYL转移基因促进甲基化公开(公告)号：US20100144867A1
公开(公告)日：2010-06-10
申请号：US12520386
申请日：2007-12-19
申请人： Francis Barany , Yu-Wei Cheng , Philip Paty , Daniel Notterman
发明人： Francis Barany , Yu-Wei Cheng , Philip Paty , Daniel Notterman
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
摘要： The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed.
摘要翻译： 本发明涉及使用卵磷脂：视黄醇酰基转移酶（LRAT）基因启动子甲基化状态评估受试者的癌症状态的方法。 还公开了分析和定量LRAT基因启动子甲基化水平的方法。 本发明还涉及通过评估LRAT mRNA表达和LRAT蛋白表达来测定患有癌症的受试者的预后的方法。 还公开了癌症检测，诊断，预后和治疗方法。
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9.发明申请FACILE SYNTHESIS OF A SERIES OF LIQUID CRYSTALLINE 2-(4'-ALKOXYPHENYL)-5-CYANOPYRIDINES 有权一系列液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成公开(公告)号：US20080306276A1
公开(公告)日：2008-12-11
申请号：US11760985
申请日：2007-06-11
申请人： Win-Long Chia , Yu-Wei Cheng
发明人： Win-Long Chia , Yu-Wei Cheng
IPC分类号： C07D213/02
CPC分类号： C07D213/84
摘要： The invention relates to a facile synthesis of a series of 2-(4′-alkoxyphenyl)-5-cyanopyridine liquid crystal compounds which are represented by the following formula (I): wherein CnH2n+1 is a linear alkyl group having 2-12 carbon atoms. The synthesis of the liquid crystalline 2-(4′-alkoxyphenyl)-5-cyanopyridine is completed in a two-step reaction. First, a Grignard reagent (such as 4-alkoxyphenylmagnesium bromide) is added to a 3-cyanopyridinium salt (such as N-phenyloxycarbonyl-3-cyanopyridinium chloride) to get a 1,2-dihydropyridine. Then, the 1,2-dihydropyridine is oxidized with o-chloronil to obtain the 2-(4′-alkoxyphenyl)-5-cyanopyridine.
摘要翻译： 本发明涉及一种由下式（I）表示的一系列2-（4'-烷氧基苯基）-5-氰基吡啶液晶化合物的简便合成：其中C n H 2n + 1是具有2-12个碳原子的直链烷基 碳原子。 液晶2-（4'-烷氧基苯基）-5-氰基吡啶的合成在两步反应中完成。 首先，向3-氰基吡啶鎓盐（如N-苯氧基羰基-3-氰基吡啶鎓氯化物）中加入格氏试剂（如4-烷氧基苯基溴化镁），得到1,2-二氢吡啶。 然后，用邻氯苯酚氧化1,2-二氢吡啶，得到2-（4'-烷氧基苯基）-5-氰基吡啶。
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