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1.发明授权Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof 失效噻吩-2-甲酰胺衍生物，其制备和治疗应用公开(公告)号：US07462631B2
公开(公告)日：2008-12-09
申请号：US11400702
申请日：2006-04-07
IPC分类号： A61K31/453 , A61K31/405 , A61K31/381 , C07D333/24
CPC分类号： C07D333/38 , C07D409/12
摘要： The invention discloses and claims a compound of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R11 are as defined herein. Further embodiments of the invention include a method of preparation of a compound of formula (I), its pharmaceutical composition and a method of treatment of a disease using a compound of formula (I).
摘要翻译： 本发明公开并要求具有式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 11如本文所定义。 本发明的其它实施方案包括制备式（I）化合物的方法，其药物组合物和使用式（I）化合物治疗疾病的方法。
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![N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application](/abs-image/US/2009/09/15/US07589120B2/abs.jpg.150x150.jpg)
2.发明授权N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application 失效N - [（4,5-二苯基-2-噻吩基）甲基]磺酰胺衍生物及其治疗应用公开(公告)号：US07589120B2
公开(公告)日：2009-09-15
申请号：US11775557
申请日：2007-07-10
IPC分类号： A61K31/38 , C07D333/12 , C07D409/00
CPC分类号： C07D409/12 , C07D333/20 , C07D333/34
摘要： The invention relates to compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic application.
摘要翻译： 本发明涉及式（I）化合物：其中X，R 1，R 2，R 3和R 4如本文所述。 本发明还涉及一种制备上述化合物及其治疗应用的方法。
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![N-[(4,5-DIPHENYL-2-THIENYL)METHYL]AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION](/abs-image/US/2008/01/10/US20080009543A1/abs.jpg.150x150.jpg)
3.发明申请N-[(4,5-DIPHENYL-2-THIENYL)METHYL]AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 失效N - [（4,5-二苯基-2-苯基）甲基]胺衍生物及其制备及其治疗应用公开(公告)号：US20080009543A1
公开(公告)日：2008-01-10
申请号：US11832162
申请日：2007-08-01
IPC分类号： A61K31/381 , C07D333/22
CPC分类号： C07D333/20
摘要： The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是对应于式（I）的化合物：其中X，R 1，R 2，R 3和R 3， SUB> 4 如本文所述。 本发明还涉及一种制备和应用所述化合物作为大麻素CB1受体拮抗剂的方法。
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![N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application](/abs-image/US/2010/03/30/US07687537B2/abs.jpg.150x150.jpg)
4.发明授权N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application 失效N - [（4,5-二苯基-2-噻吩基）甲基]胺衍生物及其制备方法及其应用公开(公告)号：US07687537B2
公开(公告)日：2010-03-30
申请号：US11832162
申请日：2007-08-01
IPC分类号： A61K31/38 , C07D333/08
CPC分类号： C07D333/20
摘要： The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是对应于式（I）的化合物：其中X，R 1，R 2，R 3和R 4如本文所述。 本发明还涉及一种制备和应用所述化合物作为大麻素CB1受体拮抗剂的方法。
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5.发明申请Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof 失效噻吩-2-甲酰胺衍生物，其制备和治疗应用公开(公告)号：US20060264470A1
公开(公告)日：2006-11-23
申请号：US11400702
申请日：2006-04-07
IPC分类号： A61K31/453 , A61K31/405 , C07D409/02
CPC分类号： C07D333/38 , C07D409/12
摘要： The invention discloses and claims a compound of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R11 are as defined herein. Further embodiments of the invention include a method of preparation of a compound of formula (I), its pharmaceutical composition and a method of treatment of a disease using a compound of formula (I).
摘要翻译： 本发明公开并要求具有式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 11， / SUB>如本文所定义。 本发明的其它实施方案包括制备式（I）化合物的方法，其药物组合物和使用式（I）化合物治疗疾病的方法。
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6.发明授权Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof 有权噻吩-2-甲酰胺衍生物，其制备及其治疗用途公开(公告)号：US08410137B2
公开(公告)日：2013-04-02
申请号：US13057043
申请日：2009-07-30
申请人： Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
发明人： Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
IPC分类号： A61K31/445 , C07D409/06
CPC分类号： C07D409/06 , C07D409/14
摘要： The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n′—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
摘要翻译： 本发明的主题是对应于式（I）的化合物，其中：R 1和R 2与它们所连接的氮原子一起构成含有4至7个原子的饱和杂环基团，其优选被取代; 两个取代基R 3和R 6中的一个是Y-A-R 9基团; Y是氧原子或-S（O）n'-或-OSO 2基团; A是未取代的（C 1 -C 4）亚烷基; R9是-OR19，-CH3，-NR19R20，-CONR19R20，-NR15COR19，-S（O）nR21或-NR13SO2R21基团; -R10是氢原子或（C1-C4）烷基。 本发明还涉及式（I）化合物的制备方法和治疗用途。
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公开(公告)号：US08680102B2
公开(公告)日：2014-03-25
申请号：US12942780
申请日：2010-11-09
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。
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公开(公告)号：US20110152320A1
公开(公告)日：2011-06-23
申请号：US12942780
申请日：2010-11-09
IPC分类号： A61K31/4545 , C07D401/14 , C07D401/06 , A61K31/454 , A61P29/00 , A61P25/04 , A61P35/00 , A61P1/00 , A61P19/02 , A61P25/16 , A61P25/28
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。
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![N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists](/abs-image/US/2010/03/09/US07674821B2/abs.jpg.150x150.jpg)
9.发明授权N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists 失效N - [（4,5-二苯基-3-烷基-2-噻吩基）甲基]胺[酰胺，磺酰胺，氨基甲酸酯和尿素）衍生物作为大麻素CB1受体拮抗剂公开(公告)号：US07674821B2
公开(公告)日：2010-03-09
申请号：US11764378
申请日：2007-06-18
IPC分类号： A61K31/381 , C07D333/22
CPC分类号： C07D333/20
摘要： The invention concerns compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also concerns a method for preparing said compounds and their use as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还涉及制备所述化合物的方法及其作为大麻素CB1受体拮抗剂的用途。
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公开(公告)号：US07381727B2
公开(公告)日：2008-06-03
申请号：US11625616
申请日：2007-01-22
IPC分类号： A61K31/4025 , A61K31/445 , A61K31/496 , C07D207/30 , C07D401/02 , C07D403/02
CPC分类号： C07D409/12 , C07D207/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds and their therapeutic use.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 9， 如本文所定义。 本发明还涉及制备所述化合物的方法及其治疗用途。
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