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公开(公告)号：US20240060068A1
公开(公告)日：2024-02-22
申请号：US18256428
申请日：2021-12-10
申请人： Francis G. FANG , Dai-Shik KIM , Hyeong Wook CHOI , Yoshinori TAKAHASHI , Kenji KIKUTA , Hikaru KAWASHIMA , Toshiki KUROKAWA , Tamaki HOSHIKAWA , Mingde SHAN , John WANG , Eisai R&D Management Co., Ltd.
发明人： Francis G. Fang , Dae-Shik Kim , Hyeong Wook Choi , Yoshinori Takahashi , Kenji Kikuta , Hikaru Kawashima , Wataru Itano , Toshiki Kurokawa , Tamaki Hoshikawa , Mingde SHAN , John Wang
IPC分类号： C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , C07H21/04 , C12N2310/341 , C12N2310/3233 , C12N2310/315
摘要： Gapmers or pharmaceutically acceptable salt of the gapmers and methods of making the gapmers are provided. The gapmers include a gap region that contains deoxyribonucleosides linked to each other by phosphorothioate bonds, a 5′ wing region positioned at the 5′ end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds, and a 3′ wing region positioned at the 3′ end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds. Antisense oligonucleotides are also provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription.
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公开(公告)号：US20190071452A1
公开(公告)日：2019-03-07
申请号：US16122116
申请日：2018-09-05
发明人： Yoshiaki Ohashi , Yoshihiko Norimine , Tamaki Hoshikawa , Yu Yoshida , Yoshihisa Kobayashi , Nobuhiro Sato , Koji Hagiwara
IPC分类号： C07D495/22 , A61P25/28 , A61P25/16
摘要： The present invention provides compounds represented by formulas (I) to (VI) or pharmaceutically acceptable salts thereof.
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公开(公告)号：US11420980B2
公开(公告)日：2022-08-23
申请号：US17021544
申请日：2020-09-15
IPC分类号： C07D495/22 , A61P25/28 , A61P25/00 , A61P25/16
摘要： Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
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公开(公告)号：US11267821B2
公开(公告)日：2022-03-08
申请号：US16807335
申请日：2020-03-03
发明人： Yoshiaki Ohashi , Yoshihiko Norimine , Tamaki Hoshikawa , Yu Yoshida , Yoshihisa Kobayashi , Nobuhiro Sato , Koji Hagiwara , Nobuaki Sato , Shinsuke Hirota , Takaaki Harada , Hikaru Yoshimura
IPC分类号： C07D495/22 , A61K31/551 , A61P25/00 , C07D491/22 , C07D491/147
摘要： The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:
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公开(公告)号：US10239889B1
公开(公告)日：2019-03-26
申请号：US16122116
申请日：2018-09-05
发明人： Yoshiaki Ohashi , Yoshihiko Norimine , Tamaki Hoshikawa , Yu Yoshida , Yoshihisa Kobayashi , Nobuhiro Sato , Koji Hagiwara
IPC分类号： A61K31/551 , A61P25/00 , C07D495/22 , A61P25/16 , A61P25/28
摘要： The present invention provides compounds represented by formulas (1) to (VI) or pharmaceutically acceptable salts thereof:
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公开(公告)号：US11358972B2
公开(公告)日：2022-06-14
申请号：US16807335
申请日：2020-03-03
发明人： Yoshiaki Ohashi , Yoshihiko Norimine , Tamaki Hoshikawa , Yu Yoshida , Yoshihisa Kobayashi , Nobuhiro Sato , Koji Hagiwara , Nobuaki Sato , Shinsuke Hirota , Takaaki Harada , Hikaru Yoshimura
IPC分类号： C07D495/22 , A61K31/551 , A61P25/00 , C07D491/22 , C07D491/147
摘要： The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:
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公开(公告)号：US20210024541A1
公开(公告)日：2021-01-28
申请号：US17021544
申请日：2020-09-15
IPC分类号： C07D495/22 , A61P25/00 , A61P25/28 , A61P25/16
摘要： Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
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公开(公告)号：US20200283452A1
公开(公告)日：2020-09-10
申请号：US16807335
申请日：2020-03-03
发明人： Yoshiaki Ohashi , Yoshihiko Norimine , Tamaki Hoshikawa , Yu Yoshida , Yoshihisa Kobayashi , Nobuhiro Sato , Koji Hagiwara , Nobuaki Sato , Shinsuke Hirota , Takaaki Harada , Hikaru Yoshimura
IPC分类号： C07D495/22 , C07D491/147 , C07D491/22
摘要： The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:
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