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公开(公告)号：US10562888B2
公开(公告)日：2020-02-18
申请号：US15566527
申请日：2016-04-13
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Moniz , Kristen Sanders , Arani Chanda , Kenshi Yoshida
IPC: C07D403/12 , A61K31/505
Abstract: A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.
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公开(公告)号：US20210024541A1
公开(公告)日：2021-01-28
申请号：US17021544
申请日：2020-09-15
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Yoshiaki Ohashi , Tamaki Hoshikawa , Nobuaki Sato , Ikuo Kushida
IPC: C07D495/22 , A61P25/00 , A61P25/28 , A61P25/16
Abstract: Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
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公开(公告)号：US09334239B2
公开(公告)日：2016-05-10
申请号：US14438366
申请日：2013-12-19
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Masaharu Gotoda , Kenshi Yoshida , Nao Shibuguchi
IPC: C07D215/48
CPC classification number: C07D215/48 , C07B2200/13
Abstract: The invention provides an amorphous form of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
Abstract translation: 本发明提供无定形形式的4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺。
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公开(公告)号：US11498916B2
公开(公告)日：2022-11-15
申请号：US16722838
申请日：2019-12-20
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Moniz , Kristen Sanders , Arani Chanda , Kenshi Yoshida , Ming-Hong Hao , Dominic Reynolds , Sudeep Prajapati , Anand Selvaraj , Takashi Satoh , John Wang
IPC: C07D403/12 , C07D239/48 , A61K31/505
Abstract: A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-y1)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.
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公开(公告)号：US11420980B2
公开(公告)日：2022-08-23
申请号：US17021544
申请日：2020-09-15
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Yoshiaki Ohashi , Tamaki Hoshikawa , Nobuaki Sato , Ikuo Kushida
IPC: C07D495/22 , A61P25/28 , A61P25/00 , A61P25/16
Abstract: Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
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Patent Agency Ranking
公开(公告)号：US20160002165A1
公开(公告)日：2016-01-07
申请号：US14768520
申请日：2014-03-10
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kenshi Yoshida , Ikuo Kushida
IPC: C07D211/58 , C07C59/50
CPC classification number: C07D211/58 , C07C59/50 , C07D401/12
Abstract: An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof.
Abstract translation: 2 - [（3S，4R）-1 - {[2-氯-6-（三氟甲基）苯基]甲基} -3 - {[1-（环己-1-烯-1-基甲基） 哌啶-4-基]氨基甲酰基} -4-甲基吡咯烷-3-基]乙酸及其结晶。
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公开(公告)号：US20150291532A1
公开(公告)日：2015-10-15
申请号：US14438366
申请日：2013-12-19
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Masaharu Gotoda , Kenshi Yoshida , Nao Shibuguchi
IPC: C07D215/48
CPC classification number: C07D215/48 , C07B2200/13
Abstract: The invention provides an amorphous form of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
Abstract translation: 本发明提供无定形形式的4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺。
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公开(公告)号：US09951047B2
公开(公告)日：2018-04-24
申请号：US15500429
申请日：2015-08-17
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Shunsuke Ozaki , Kenshi Yoshida
IPC: C07D401/14 , A61K31/44 , C07C55/10 , C07C55/02
CPC classification number: C07D401/14 , A61K31/4545 , C07B2200/13 , C07C55/02 , C07C55/10
Abstract: The present invention provides salts consisting of an organocarboxylic acid selected from the group consisting of succinic acid and maleic acid and a compound represented by formula (I) and crystals thereat which can be used as bulk materials for pharmaceuticals.
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公开(公告)号：US20170217935A1
公开(公告)日：2017-08-03
申请号：US15500429
申请日：2015-08-17
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Shunsuke Ozaki , Kenshi Yoshida
IPC: C07D401/14 , C07C55/02 , C07C55/10
CPC classification number: C07D401/14 , A61K31/4545 , C07B2200/13 , C07C55/02 , C07C55/10
Abstract: The present invention provides salts consisting of an organocarboxylic acid selected from the group consisting of succinic acid and maleic acid and a compound represented by formula (I) and crystals thereat which can be used as bulk materials for pharmaceuticals.
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公开(公告)号：US09550732B2
公开(公告)日：2017-01-24
申请号：US14768520
申请日：2014-03-10
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Ikuo Kushida
IPC: C07D211/58 , C07D401/12 , C07C59/50
CPC classification number: C07D211/58 , C07C59/50 , C07D401/12
Abstract: An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof.
Abstract translation: 2 - [（3S，4R）-1 - {[2-氯-6-（三氟甲基）苯基]甲基} -3 - {[1-（环己-1-烯-1-基甲基） 哌啶-4-基]氨基甲酰基} -4-甲基吡咯烷-3-基]乙酸及其结晶。
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