-
![Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide](/abs-image/US/2019/04/16/US10259817B2/abs.jpg.150x150.jpg)
公开(公告)号：US10259817B2
公开(公告)日：2019-04-16
申请号：US15577858
申请日：2016-06-21
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Ikuo Kushida , Yoko Ito
IPC: C07D487/04 , A61K31/53 , A61P35/00
Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.
-
公开(公告)号：US20210323972A1
公开(公告)日：2021-10-21
申请号：US16605424
申请日：2018-05-07
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Ikuo Kushida , Yoko Ito , Masaaki Matsuda
IPC: C07D491/147
Abstract: The present invention provides a crystal of the compound represented by formula (I) having applicability as a drug substance of pharmaceuticals.
-
公开(公告)号：US20250051322A1
公开(公告)日：2025-02-13
申请号：US18722917
申请日：2023-01-12
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Ikuo Kushida , Yoko Ito , So Yasui , Takashi Fukuyama , Nobuaki Sato , Taro Asaba
IPC: C07D451/02 , A61K31/506
Abstract: Crystals of compounds represented by formula (I) having potential as drug substances for pharmaceuticals, as well as salts of compounds represented by formula (I) and their crystals.
-
公开(公告)号：US11420980B2
公开(公告)日：2022-08-23
申请号：US17021544
申请日：2020-09-15
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Yoshiaki Ohashi , Tamaki Hoshikawa , Nobuaki Sato , Ikuo Kushida
IPC: C07D495/22 , A61P25/28 , A61P25/00 , A61P25/16
Abstract: Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
-
公开(公告)号：US20160002165A1
公开(公告)日：2016-01-07
申请号：US14768520
申请日：2014-03-10
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kenshi Yoshida , Ikuo Kushida
IPC: C07D211/58 , C07C59/50
CPC classification number: C07D211/58 , C07C59/50 , C07D401/12
Abstract: An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof.
Abstract translation: 2 - [（3S，4R）-1 - {[2-氯-6-（三氟甲基）苯基]甲基} -3 - {[1-（环己-1-烯-1-基甲基） 哌啶-4-基]氨基甲酰基} -4-甲基吡咯烷-3-基]乙酸及其结晶。
-
Patent Agency Ranking
公开(公告)号：US20210024541A1
公开(公告)日：2021-01-28
申请号：US17021544
申请日：2020-09-15
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Yoshiaki Ohashi , Tamaki Hoshikawa , Nobuaki Sato , Ikuo Kushida
IPC: C07D495/22 , A61P25/00 , A61P25/28 , A61P25/16
Abstract: Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals.
-
![Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide](/abs-image/US/2018/05/24/US20180141950A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180141950A1
公开(公告)日：2018-05-24
申请号：US15577858
申请日：2016-06-21
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Ikuo Kushida , Yoko Ito
IPC: C07D487/04 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04 , A61K31/53 , A61P35/00 , C07B2200/13
Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl} methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.
-
公开(公告)号：US11691990B2
公开(公告)日：2023-07-04
申请号：US17058406
申请日：2019-08-14
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jun Niijima , Hirofumi Kuroda , So Yasui , Yoko Ito , Ikuo Kushida
IPC: C07D519/00 , A61P35/00 , C07F9/6587 , C07H21/00 , A61K31/7084
CPC classification number: C07D519/00 , C07B2200/13
Abstract: The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.
-
![Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide](/abs-image/US/2019/03/05/US10221183B2/abs.jpg.150x150.jpg)
公开(公告)号：US10221183B2
公开(公告)日：2019-03-05
申请号：US15577858
申请日：2016-06-21
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Ikuo Kushida , Yoko Ito
IPC: C07D487/04 , A61K31/53 , A61P35/00
Abstract: The present invention provides a crystal of (6S,9aS)-N-benzyl-8-({6-[3-4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.
-
公开(公告)号：US09550732B2
公开(公告)日：2017-01-24
申请号：US14768520
申请日：2014-03-10
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kenshi Yoshida , Ikuo Kushida
IPC: C07D211/58 , C07D401/12 , C07C59/50
CPC classification number: C07D211/58 , C07C59/50 , C07D401/12
Abstract: An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof.
Abstract translation: 2 - [（3S，4R）-1 - {[2-氯-6-（三氟甲基）苯基]甲基} -3 - {[1-（环己-1-烯-1-基甲基） 哌啶-4-基]氨基甲酰基} -4-甲基吡咯烷-3-基]乙酸及其结晶。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.037 seconds)
