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    Heterocyclic tetracyclic tetrahydrofuran derivatives
    6.
    发明授权
    Heterocyclic tetracyclic tetrahydrofuran derivatives 有权
    杂环四环四氢呋喃衍生物

    公开(公告)号：US08404729B2

    公开(公告)日：2013-03-26

    申请号：US13028596

    申请日：2011-02-16

    申请人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    发明人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    IPC分类号： A61K31/34 ,  C07D307/93

    CPC分类号： C07D495/04 ,  C07D491/14 ,  C07D495/14

    摘要： This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders for their production. The compounds according to the invention can be represented by general Formula (I) and comprise also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.

    摘要翻译： 本发明涉及对5-羟色胺受体，特别是5-HT2A和5-HT2C受体，对多巴胺受体，特别是多巴胺D2受体和去甲肾上腺素再吸收抑制性质的结合亲和力的新型取代的杂环四环四氢呋喃衍生物，包含根据 本发明，其用作药物，特别是用于预防和/或治疗一系列精神和神经障碍，特别是用于其生产的某些精神病性，心血管和胃肠功能障碍。 根据本发明的化合物可以由通式（I）表示，并且还包括其药学上可接受的酸或碱加成盐，其立体化学异构形式，其N-氧化物形式及其前药，其中所有取代基定义为 在权利要求1中。

    HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES
    8.
    发明申请
    HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES 有权
    杂环四取代四氢呋喃衍生物

    公开(公告)号：US20110144094A1

    公开(公告)日：2011-06-16

    申请号：US13028596

    申请日：2011-02-16

    申请人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    发明人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    IPC分类号： A61K31/55 ,  C07D495/14 ,  A61K31/38 ,  C07D495/04 ,  A61K31/381 ,  C07D401/14 ,  A61K31/4535 ,  C07D471/10 ,  A61K31/438 ,  C07D405/14 ,  A61K31/4025 ,  C07D403/14 ,  A61K31/496 ,  C07D471/14 ,  A61P25/00

    CPC分类号： C07D495/04 ,  C07D491/14 ,  C07D495/14

    摘要： This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production.The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.

    摘要翻译： 本发明涉及对5-羟色胺受体，特别是5-HT2A和5-HT2C受体，对多巴胺受体，特别是多巴胺D2受体和去甲肾上腺素再吸收抑制性质的结合亲和力的新型取代的杂环四环四氢呋喃衍生物，包含根据 本发明作为药物的用途，特别是用于预防和/或治疗一系列精神病和神经障碍，特别是某些精神病，心血管和胃肠功能紊乱及其制备方法。 根据本发明的化合物可以由通式（I）表示，并且还包括其药学上可接受的酸或碱加成盐，其立体化学异构形式，其N-氧化物形式及其前药，其中所有取代基定义为 在权利要求1中。

    Unsaturated tetracyclic tetrahydrofuran derivatives
    10.
    发明授权
    Unsaturated tetracyclic tetrahydrofuran derivatives 失效
    不饱和四环四氢呋喃衍生物

    公开(公告)号：US08022102B2

    公开(公告)日：2011-09-20

    申请号：US11571090

    申请日：2005-06-21

    申请人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    发明人： José Maria Cid-Núñez ,  Antonius Adrianus Hendrikus Petrus Megens ,  Andrés Avelino Trabanco-Suárez

    IPC分类号： A61K31/343 ,  C07D307/93

    CPC分类号： C07D307/935 ,  C07D303/10 ,  C07D317/26 ,  C07D333/80 ,  C07D335/04 ,  C07D405/06 ,  C07D405/12 ,  C07D491/04 ,  C07D491/10 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14

    摘要： This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production.The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substitutents are defined as in Claim 1.

    摘要翻译： 本发明涉及对5-羟色胺受体，特别是5-HT2A和5-HT2C受体具有结合亲和性，对多巴胺受体，特别是多巴胺D2受体和去甲肾上腺素再摄取抑制性质的新型取代的不饱和四环四氢呋喃衍生物，包含根据 本发明作为药物的用途，特别是用于预防和/或治疗一系列精神病和神经障碍，特别是某些精神病，心血管和胃肠功能紊乱及其制备方法。 根据本发明的化合物可以由通式（I）表示，还包括其药学上可接受的酸或碱加成盐，其立体化学异构形式，其N-氧化物形式及其前药，其中所有取代基定义为 在权利要求1中。