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    Aspartame synthesis
    2.
    发明授权
    Aspartame synthesis 失效
    天冬甜素合成

    公开(公告)号：US4656304A

    公开(公告)日：1987-04-07

    申请号：US614150

    申请日：1984-05-25

    申请人： Ernesto Oppici ,  Franco Dallatomasina ,  Pietro Giardino

    发明人： Ernesto Oppici ,  Franco Dallatomasina ,  Pietro Giardino

    IPC分类号： C07C231/00 ,  A23L27/30 ,  C07K5/072 ,  C07K5/075 ,  C07C101/02

    CPC分类号： C07K5/0613

    摘要： A process for the preparation of the N-L-.alpha.-aspartyl-L-phenylalanine 1-methyl ester (aspartame) which is characterized by adding phosphoric acid and a lower alkyl alcohol to the reaction mixture containing N-formyl .alpha.-L-aspartyl- and .beta.-L-aspartyl-L-phenyl-alanine methyl ester and only one of the resultant deformylated isomers, i.e. aspartame phosphate precipitates.The .alpha.-isomer phosphate is collected by filtration and converted to free aspartame by treatment with a base.

    摘要翻译： 制备NL-α-天门冬酰基-L-苯丙氨酸1-甲酯（阿斯巴甜）的方法，其特征在于向含有N-甲酰基α-L-天冬氨酰基的反应混合物中加入磷酸和低级烷基醇 β-L-天冬氨酰基-L-苯基 - 丙氨酸甲酯和仅一种所得的去甲基化异构体，即阿斯巴甜磷酸盐沉淀物。 通过过滤收集α-异构体磷酸酯，并用碱处理转化成游离的阿斯巴甜。

    Process for purifying Tylosin
    3.
    发明授权
    Process for purifying Tylosin 失效
    纯化泰乐菌素的方法

    公开(公告)号：US4568740A

    公开(公告)日：1986-02-04

    申请号：US594318

    申请日：1984-03-28

    申请人： Ernesto Oppici ,  Onorino G. Rosa ,  Carlo Varesio ,  Giovanni Lazzari ,  Danillo Fabris

    发明人： Ernesto Oppici ,  Onorino G. Rosa ,  Carlo Varesio ,  Giovanni Lazzari ,  Danillo Fabris

    IPC分类号： C12P19/62 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Disclosed is a process for purifying Tylosin by selective adsorption of the fermentation broth previously brought to 7.5-10.0 pH on polymeric resins and by subsequent deadsorption of the purified product with a aqueous-alcoholic or aqueous-acetonic solution and further purification of the eluate by filtration through macroreticular weak anion resins.

    摘要翻译： 公开了一种通过选择性吸附先前在聚合物树脂上达到7.5-10.0 pH的发酵液并通过随后用含水醇或水性乙酰水溶液对纯化产物进行吸附来纯化泰乐菌素的方法，并通过过滤进一步纯化洗脱液 通过大网络弱阴离子树脂。

    Process for preparing .alpha.-aminoalcohols
    6.
    发明授权
    Process for preparing .alpha.-aminoalcohols 失效
    制备{60-氨基醇的方法

    公开(公告)号：US3953513A

    公开(公告)日：1976-04-27

    申请号：US521997

    申请日：1974-11-08

    申请人： Ernesto Oppici

    发明人： Ernesto Oppici

    IPC分类号： C07C43/14 ,  C07C20060101 ,  C07C41/00 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/04 ,  C07C215/08 ,  C07C301/00 ,  C07C303/28 ,  C07C309/73 ,  C07C89/02

    CPC分类号： C07C215/08

    摘要： Process for preparing an .alpha.-aminoalcohol of formula ##EQU1## wherein R represents hydrogen or alkyl of from 1 to 5 carbon atoms, which comprises contacting a compound of formula ##EQU2## wherein R has the same meaning as above, with an alcohol of formula R'-OH wherein R' represents benzyl or the group ##EQU3## in which R" and R"' are independently selected from hydrogen and alkyl of from 1 to 4 carbon atoms in an organic solvent, in the presence of a basic catalyst, at from about 140.degree. to about 170.degree.C., treating the obtained product of formula ##EQU4## wherein R and R' have the above meanings, with at least an equimolecular amount of a p-toluene-sulfonyl halide, at from about -5.degree. to about 20.degree.C. in the presence of a tertiary organic nitrogen-containing base and reacting in a closed system the resulting compound of formula ##EQU5## wherein R and R' are as above defined, with an excess of gaseous ammonia, in the presence of an inert organic solvent, at from about 95.degree. to about 120.degree.C. and recovering the resulting product as its acid addition salt.

    摘要翻译： 制备式R-CH-CH 2 OH | NH 2的α-氨基醇的方法，其中R表示氢或1至5个碳原子的烷基，其包括使式R-CH-CH 2 ANGLE O的化合物接触，其中R具有 与上述相同的含有式R'-OH的醇，其中R'表示苄基或基团R“ANGLE C = CH-CH 2 -R”，其中R“和R”'独立地选自 氢和在有机溶剂中，在碱性催化剂存在下，在约140至约170℃下具有1至4个碳原子的烷基，处理所得到的式R-CH-CH 2 -OR' OH，其中R和R'具有上述含义，在至少等摩尔量的对甲苯磺酰卤中，在约-5至约20℃下，在叔有机含氮碱存在下，和 在封闭体系中反应所得的式R-CH-CH 2 -OR'| OO | ANGLE S-O的化合物，其中R和R'如上所定义，与过量的气态弹药 在惰性有机溶剂的存在下，在约95℃至约120℃下回收所得产物作为其酸加成盐。

    Method for extracting phenylalanine from broths of bioconversion
    7.
    发明授权
    Method for extracting phenylalanine from broths of bioconversion 失效
    从生物转化肉汤中提取苯丙氨酸的方法

    公开(公告)号：US4668821A

    公开(公告)日：1987-05-26

    申请号：US827676

    申请日：1986-02-10

    申请人： Onorino G. Rosa ,  Carlo Varesio ,  Ernesto Oppici

    发明人： Onorino G. Rosa ,  Carlo Varesio ,  Ernesto Oppici

    IPC分类号： C12P13/22 ,  C07C99/12

    CPC分类号： C12P13/222

    摘要： The invention discloses a method for extracting phenylalanine from the broths obtained by enzymatic processes; this method consists in flocculating and filtering the broth, concentrating the filtrate followed by filtering off the resulting cinnamic acid, decolorating and concentrating the filtrate to obtain phenylalanine crystals at a very pure degree.

    摘要翻译： 本发明公开了一种通过酶法从肉汤中提取苯丙氨酸的方法; 该方法包括絮凝和过滤肉汤，浓缩滤液，滤出所得肉桂酸，脱色并浓缩滤液，以非常纯的度得到苯丙氨酸晶体。