-
公开(公告)号：US5424314A
公开(公告)日：1995-06-13
申请号：US207361
申请日：1994-03-07
IPC分类号： A61K31/435 , A61K31/4375 , A61P9/00 , A61P9/10 , A61P25/24 , A61P25/26 , A61P25/28 , C07D461/00 , A61K31/445
CPC分类号： C07D461/00
摘要： A compound in all racemic or optionally active forms selected from the group consisting of a compound of the formula ##STR1## where the substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-anoxic activity and a novel process and intermediates for their preparation.
摘要翻译： 所有外消旋或任选活性形式的化合物，其选自下列化合物：其中取代基如说明书中所定义，及其无毒的药学上可接受的具有抗缺氧性的酸加成盐 活动和一个新的工艺和中间体的准备。
-
公开(公告)号：US4975427A
公开(公告)日：1990-12-04
申请号：US415196
申请日：1989-09-29
IPC分类号： A61K31/54 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , C07D209/14 , C07D417/06 , C07D513/14 , C07D513/22
CPC分类号： C07D417/06 , C07D209/14 , C07D513/14
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms, hydroxy, trifluoromethyl and nitro, n is 0,1 or 2 and the group: ##STR2## in all possible racemic or optically active isomer forms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic, anti-anoxic and anti-ischemic neuronal protective properties.
摘要翻译： 选自下列化合物的化合物：其中R 1和R 2分别选自氢，卤素，具有1至5个碳原子的烷基和烷氧基，羟基，三氟甲基和硝基 ，所有可能的外消旋或旋光异构体形式的n为0,1或2，并且组：
+ TR 及其具有止痛，抗缺氧和抗缺血的无毒的药学上可接受的酸加成盐 神经元保护性质。 -
公开(公告)号：US6004979A
公开(公告)日：1999-12-21
申请号：US71586
申请日：1998-05-01
IPC分类号： A61K31/47 , C07D215/06 , C07D215/12 , C07D215/22 , C07D215/233 , C07D215/36 , C07D215/44 , C07D237/28 , C07D239/74 , C07D401/10
CPC分类号： C07D215/233 , C07D215/06 , C07D215/12 , C07D215/36 , C07D215/44 , C07D237/28 , C07D239/74 , C07D401/10
摘要： Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.
摘要翻译： 具有所有可能的外消旋，对映异构体和非对映异构体形式的式的化合物及其与具有拮抗血管紧张素II受体的酸和碱的无毒的药学上可接受的盐，以及它们的性质的方法和新的中间体。
-
公开(公告)号：US5478938A
公开(公告)日：1995-12-26
申请号：US216035
申请日：1994-03-22
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P15/00 , A61P25/28 , A61P27/06 , C07C229/30 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/22 , C07D215/233 , C07D215/48 , C07D217/12 , C07D217/18 , C07D217/22 , C07D217/24 , C07D217/26 , C07D237/28 , C07D237/30 , C07D239/72 , C07D241/40 , C07D401/06 , C07D403/06
CPC分类号： C07D215/233 , C07C229/30 , C07D215/12 , C07D215/48 , C07D217/18 , C07D217/22 , C07D237/28
摘要： Novel bicyclic compounds in all possible racemic, enantiomeric and diasteroisomeric forms of the formula ##STR1## having antagonistic properties for angiotensin II receptors and novel intermediates and process for their preparation.
摘要翻译： 新型双环化合物具有所有可能的外消旋，对映异构体和非对映体形式，具有血管紧张素II受体和新型中间体的拮抗性质及其制备方法。
-
公开(公告)号：US5817674A
公开(公告)日：1998-10-06
申请号：US583637
申请日：1996-01-05
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/28 , A61P43/00 , C07D215/06 , C07D215/12 , C07D215/22 , C07D215/233 , C07D215/36 , C07D215/44 , C07D215/48 , C07D217/04 , C07D217/22 , C07D237/22 , C07D237/28 , C07D239/72 , C07D239/74 , C07D241/40 , C07D401/10 , A61K31/395
CPC分类号： C07D215/233 , C07D215/06 , C07D215/12 , C07D215/36 , C07D215/44 , C07D237/28 , C07D239/74 , C07D401/10
摘要： Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.
摘要翻译： 具有所有可能的外消旋，对映异构体和非对映异构体形式的式的化合物及其与具有拮抗血管紧张素II受体的酸和碱的无毒的药学上可接受的盐，以及它们的性质的方法和新的中间体。
-
公开(公告)号：US5324839A
公开(公告)日：1994-06-28
申请号：US832003
申请日：1992-02-06
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P15/00 , A61P25/28 , A61P27/06 , C07C229/30 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/22 , C07D215/233 , C07D215/48 , C07D217/12 , C07D217/18 , C07D217/22 , C07D217/24 , C07D217/26 , C07D237/28 , C07D237/30 , C07D239/72 , C07D241/40 , A61K31/41 , A61K31/42 , A61K31/425 , C07D401/10 , C07D403/02
CPC分类号： C07D215/233 , C07C229/30 , C07D215/12 , C07D215/48 , C07D217/18 , C07D217/22 , C07D237/28
摘要： Novel bicyclic compounds in all possible racemic, enantiomeric and diasteroisomeric forms of the formula ##STR1## having antagonistic properties for angiotensin II receptors and novel intermediates and process for their preparation.
摘要翻译： 新型双环化合物具有所有可能的外消旋，对映异构体和非对映体形式，具有血管紧张素II受体和新型中间体的拮抗性质及其制备方法。
-
7.发明授权Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them 失效其作为药物和含有它们的药物组合物的二十二碳三烯酸的取代衍生物
公开(公告)号：US5093337A
公开(公告)日：1992-03-03
申请号：US391511
申请日：1989-07-18
IPC分类号： C07D461/00 , A61K20060101 , A61K31/435 , A61K31/445 , A61K31/475 , A61K31/495 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/24 , A61P25/26 , C07D20060101
CPC分类号： C07D461/00
摘要： The invention concerns compounds of formula (I); ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, identical or different, stand for hydrogen, halogen, alkyl or alkoxy (C.sub.1-5), hydroxy, trifluoromethyl, nitro, amino, alkylamino, dialkylamino, acylamino, R.sub.1, R.sub.2 and R.sub.3 being unable to stand for hydrogen simultaneously and in which (a) stands for (b), (c), or (d), all possible isomeric forms of said products of formula (I) being racemic or optically active, as well as their additional salts with acids, their preparation and the new intermediate products obtained, their application as drugs in particular nootropes, antidepressants, neuronal protectors, anti-anoxics, anti-ischemics, and the compositions containing them.
摘要翻译： PCT No.PCT / FR88 / 00562 Sec。 371日期：1989年7月18日 102（e）日期1989年7月18日PCT提交1988年11月16日PCT公布。 出版物WO89 / 04830 日期：1989年6月1日。本发明涉及式（I）化合物。 其中R1，R2和R3相同或不同，代表氢，卤素，烷基或烷氧基（C1-5），羟基，三氟甲基，硝基，氨基，烷基氨基，二烷基氨基，酰基氨基， R1，R2和R3不能同时代表氢，其中（a）代表（b），（c）或（d），所有式（I）产物的所有可能的异构形式是外消旋或光学活性的 以及它们与酸的附加盐，它们的制备和获得的新的中间产物，它们作为药物特别是助推剂，抗抑郁药，神经元保护剂，抗缺氧剂，抗缺血剂以及含有它们的组合物的应用。
-
8.发明授权
公开(公告)号：US4904655A
公开(公告)日：1990-02-27
申请号：US302810
申请日：1989-01-26
IPC分类号： C07D209/14 , A61K31/535 , A61P25/04 , A61P25/06 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/12 , C07D209/18 , C07D413/06 , C07D498/14 , C07D498/22
CPC分类号： C07D498/22
摘要： Novel compounds selected from the group consisting of all possible racemic or optically active forms of compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, -OH, -CF.sub.3 and -NO.sub.2 and ##STR2## is selected from the group consisting of ##STR3## and their non-toxic, pharmaceutically acceptable acid addition salts having a very good analgesic activity as well as antidepressive, neuronal protective, anti-anoxic, anti-ischemic and no-otropic activities.
摘要翻译： 选自下列化合物的新化合物：所有可能的外消旋或旋光活性形式的下式化合物其中R 1和R 2分别选自氢，烷基和1至5个碳原子的烷基，-OH ，-CF 3和-NO 2和
选自 及其无毒的药学上可接受的具有非常好的镇痛活性的酸加成盐以及抗抑郁，神经元保护，抗缺氧，抗 - 缺血和非嗜性活动。 -
9.发明授权Substituted derivatives of 20,21-dinoreburnamenine, their preparation process and the new intermediates thus obtained, their use as medicaments and the pharmaceutical compositions containing them 失效取代的衍生物20,21-二内啡宁，其制备方法和由此获得的新中间体，它们作为药物的用途和含有它们的药物组合物
公开(公告)号：US5332748A
公开(公告)日：1994-07-26
申请号：US5662
申请日：1993-01-19
IPC分类号： C07D461/00 , A61K20060101 , A61K31/435 , A61K31/445 , A61K31/475 , A61K31/495 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/24 , A61P25/26 , C07D20060101 , A61K31/44
CPC分类号： C07D461/00
摘要： A compound and all possible racemic or optically active isomer forms, selected from the group consisting of compound of the formula ##STR1## wherein the substituents are defined as set forth in the application as filed. Useful for treating cerebral insufficiencies of anoxic or ischemic origin.
摘要翻译： 选自下列化合物的化合物和所有可能的外消旋或旋光异构体形式，其中取代基定义如申请所述。 用于治疗缺氧或缺血起源的脑功能不全。
-
10.发明授权Method of treating depression with optically active isomers of 20,21-dinoreburnamenines 失效用20,21-二辛胺盐酸光学活性异构体治疗抑郁症的方法
公开(公告)号：US5034396A
公开(公告)日：1991-07-23
申请号：US271733
申请日：1988-11-15
IPC分类号： A61K31/435 , A61P9/00 , A61P9/10 , A61P25/24 , A61P25/26 , A61P25/28 , C07D461/00
CPC分类号： C07D461/00
摘要： A compound selected from the group consisting of optically active isomers of a racemic compound of the formula ##STR1## wherein the 3-hydrogen and 16-hydrogen are trans and ##STR2## is selected from the group consisting of ##STR3## with the --OH being .alpha. or .beta. and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant activity and an affinity for alpha.sub.2 adrenergic receptors,
摘要翻译： 选自下列化学式的旋光化合物的旋光异构体的化合物其中3-氢和16-氢是反式的，且＆lt; IMAGE＆gt;选自＆lt; IMAGE＆gt;与 - OH是α或β及其无毒的药学上可接受的酸加成盐，其具有抗抑郁活性和对α2肾上腺素能受体的亲和力，
-
-
-
-
-
-
-
-
-
搜索结果
75 条记录 (耗时 0.041 秒)
