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    Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them
    1.
    发明授权
    Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them 失效
    固定在肽聚合物上的胞壁酰肽和含有它们的药物组合物

    公开(公告)号：US4401659A

    公开(公告)日：1983-08-30

    申请号：US111701

    申请日：1980-01-14

    申请人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Louis Chedid ,  Jean Choay ,  Michael Sela ,  Edgar Lederer

    发明人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Louis Chedid ,  Jean Choay ,  Michael Sela ,  Edgar Lederer

    IPC分类号： C08G69/00 ,  C07K9/00 ,  C08G69/10 ,  C08G69/48 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K9/005 ,  Y10S930/19 ,  Y10S930/29

    摘要： A polymer of peptidic type formed by a chain formed from aminoacyl residues preferably derived of at least one of the amino-acid residues selected from the class consisting of .alpha.,.gamma.-diaminobutyric acid, ornithine, lysine, homo-lysine, of which the lateral amino functions portionally carry peptide branches of which the aminoacyl residues are preferably derived of those selected from the class consisting of alanine, glycine, .alpha.-aminobutyric acid, valine, leucine and proline, the above-said peptide polymer having an average molecular weight comprised between about 50,000 and 250,000, and to which are bound covalently, muramyl-peptide units of which the two first aminoacid residues bound to the muramyl group are stereoisomers of the D series, the second aminoacid residue having the structure of the glutamic acid.This product is useful as anti-infectious agent.

    摘要翻译： 由氨基酰基残基形成的链形成的肽类聚合物优选衍生自选自α，γ-二氨基丁酸，鸟氨酸，赖氨酸，同型赖氨酸中的至少一种氨基酸残基，其侧向 氨基功能分别携带肽分支，氨基酰基残基优选衍生自选自丙氨酸，甘氨酸，α-氨基丁酸，缬氨酸，亮氨酸和脯氨酸的那些，上述肽聚合物的平均分子量包括在 约50,000和250,000，并且共价键合的两个第一氨基酸残基与胞壁酰氨基结合的胞壁酰肽单元是D系的立体异构体，具有谷氨酸结构的第二氨基酸残基。 本品作为抗感染剂有用。

    Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives
    6.
    发明授权
    Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives 失效
    由N-乙酰胞壁酰基-L-丙氨酰-D-谷氨酸衍生物构成的免疫和抗感染佐剂

    公开(公告)号：US4153684A

    公开(公告)日：1979-05-08

    申请号：US775215

    申请日：1977-03-07

    申请人： Francoise Audibert ,  Louis Chedid ,  Pierre Lefrancier ,  Jean Choay ,  Edgar Lederer

    发明人： Francoise Audibert ,  Louis Chedid ,  Pierre Lefrancier ,  Jean Choay ,  Edgar Lederer

    IPC分类号： A61K39/39 ,  C07H15/04 ,  A61K37/02 ,  C07C103/52

    CPC分类号： C07H15/04 ,  A61K39/39 ,  A61K2039/5555

    摘要： The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglutamine and of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutamic acid, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-(.alpha.-methylamide)-glutamic and 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-isoglutamine, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-glutamic acid and their derivatives. They are particularly useful to prepare adjuvant medicinal compositions, used for increasing the efficiency of vaccines.

    摘要翻译： 本发明涉及作为免疫佐剂有效的新的水溶性物质。 这些助剂是2-（2-乙酰氨基-2-脱氧-3-OD-吡喃葡萄糖基）-D-丙酰基-L-丙氨酰-D-糖苷的甲基，乙基或丙基酯和2-（2-乙酰氨基 -2-脱氧-3-OD-吡喃葡萄糖基）-D-丙酰基-L-丙氨酰-D-谷氨酸，2-（2-乙酰氨基-2-脱氧-3-OD-吡喃葡萄糖基）-D-丙酰基-L 2-丙酰基-D-（α-甲基酰胺） - 谷氨酸和2-（2-乙酰氨基-2-脱氧-3-OD-吡喃葡萄糖基）-D-丙酰基-L-丝氨酰-D-异谷氨酰胺，2- 乙酰氨基-2-脱氧-3-OD-吡喃葡萄糖基）-D-丙酰基-L-丝氨酰-D-葡萄糖酸及其衍生物。 它们对于制备用于提高疫苗效率的辅助药物组合物特别有用。

    Oligomers of compounds of the muramyl-peptide type and medicaments containing them
    10.
    发明授权
    Oligomers of compounds of the muramyl-peptide type and medicaments containing them 失效
    胞壁酰胺类化合物的低聚物和含有它们的药物

    公开(公告)号：US4461761A

    公开(公告)日：1984-07-24

    申请号：US410727

    申请日：1982-08-23

    申请人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Edgar Sache ,  Louis Chedid ,  Jean Choay ,  Edgar Lederer

    发明人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Edgar Sache ,  Louis Chedid ,  Jean Choay ,  Edgar Lederer

    IPC分类号： A61K39/39 ,  C07K9/00 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K9/005

    摘要： The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the peptide type including at least two aminoacyl residues, the first being selected from among: L-alanyl, L-arginyl, L-asparagyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-methionyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-valyl, and the second aminoacyl is D-glutamyl or D-isoglutaminyl. They are useful for their immunoregulator properties and for the preparation of pharmaceutical compositions.

    摘要翻译： 新产品是不含N-乙酰葡糖胺单元的水溶性低聚物，其单体元素包括衍生自其中固定有至少两个氨酰基残基的肽类链的基团，第一 选自：L-丙氨酰，L-精氨酰，L-天冬酰胺基，L-组氨酰基，L-羟基脯氨酰，L-异亮氨酰，L-亮氨酰，L-甲硫氨酰，L-苯丙氨酰，L-脯氨酰，L-丝氨酰，L - 苏氨酰基，L-色氨酸，L-缬氨酰，第二氨酰基是D-谷氨酰或D-异谷氨酰胺基。 它们可用于其免疫调节剂性质和药物组合物的制备。