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    Angiogenic agents from plant extracts, gallic acid, and derivatives
    1.
    发明申请
    Angiogenic agents from plant extracts, gallic acid, and derivatives 有权
    来自植物提取物，没食子酸和衍生物的血管生成剂

    公开(公告)号：US20070031332A1

    公开(公告)日：2007-02-08

    申请号：US10559091

    申请日：2004-05-27

    申请人： Frank Greenway ,  Zhijun Liu ,  Eugene Woltering

    发明人： Frank Greenway ,  Zhijun Liu ,  Eugene Woltering

    IPC分类号： A61K51/00 ,  A61K38/21 ,  A61K38/18 ,  A61K31/7024 ,  A61K31/454 ,  A61M36/14

    CPC分类号： A61K31/192 ,  A61K31/454 ,  A61K31/7024 ,  A61K36/40 ,  A61K36/44 ,  A61K36/708 ,  A61K36/73

    摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.

    摘要翻译： 已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。 没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。 已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。 发现没食子酸的各种衍生物抑制血管生成。 中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。 石榴提取物显示抑制脂肪组织中的血管发生。 来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

    Nasally administered appetite suppressant
    2.
    发明申请
    Nasally administered appetite suppressant 审中-公开
    鼻胃食欲抑制剂

    公开(公告)号：US20070020194A1

    公开(公告)日：2007-01-25

    申请号：US11449417

    申请日：2006-06-08

    申请人： Frank Greenway ,  Linda Young

    发明人： Frank Greenway ,  Linda Young

    IPC分类号： A61L9/04 ,  A61K31/4745 ,  A61K31/4166 ,  A61K31/137 ,  A61K31/24

    CPC分类号： A61K31/137 ,  A61K31/24 ,  A61K31/4166 ,  A61K31/4745

    摘要： Methods are described for suppressing appetite through the intranasal administration of a sodium channel blocker. It has long been known that smell and taste are an important part of how the body prepares for a meal, for example the cephalic phase of insulin release before a meal. Depressing the sense of smell or taste in subjects prior to meals leads to decreased food intake, which ultimately leads to weight loss. The ability to deliver drugs to the CSF via intranasal application also provide anorexiant central effect.

    摘要翻译： 描述了通过鼻内施用钠通道阻断剂来抑制食欲的方法。 长期以来人们已经知道，嗅觉和味道是身体如何准备饭菜的重要部分，例如饭前胰岛素释放的头部相位。 在饭前沮丧的受试者的嗅觉或味觉会导致食物摄取减少，最终导致体重下降。 通过鼻内应用将药物递送至CSF的能力也提供了厌氧中心作用。

    Compositions comprising terpene compounds for treating negative sensory phenomena
    3.
    发明授权
    Compositions comprising terpene compounds for treating negative sensory phenomena 有权
    包含用于治疗阴性感觉现象的萜烯化合物的组合物

    公开(公告)号：US09415023B2

    公开(公告)日：2016-08-16

    申请号：US13058762

    申请日：2009-08-13

    申请人： Alexander McLellan ,  Frank Greenway

    发明人： Alexander McLellan ,  Frank Greenway

    IPC分类号： A61K31/045 ,  A61K31/121 ,  A61K31/122 ,  A61K31/22 ,  A61K31/351

    CPC分类号： A61K31/045 ,  A61K9/0014 ,  A61K31/121 ,  A61K31/122 ,  A61K31/22 ,  A61K31/351

    摘要： Compositions comprising terpene compounds for the treatment of negative sensory phenomena (NSP). Negative sensory phenomena is characterized by a decreased ability to sense light touch, pin prick, vibration, temperature, pain and/or reduced proprioception. The terpene compounds are preferably aromatic terpene compounds such as geraniol and citronellol and analogs thereof. The terpenes may also be used in combination. The terpenes are derived form plant essential oils or are manufactured synthetically.

    摘要翻译： 包含用于治疗阴性感觉现象（NSP）的萜烯化合物的组合物。 负感觉现象的特征在于感测轻触感，针刺，振动，温度，疼痛和/或减少本体感觉的能力下降。 萜烯化合物优选为芳族萜烯化合物，例如香叶醇和香茅醇及其类似物。 萜烯也可以组合使用。 萜烯衍生自植物精油或合成制成。

    Nasally administered appetite suppressants
    6.
    发明申请
    Nasally administered appetite suppressants 审中-公开
    鼻胃食欲抑制剂

    公开(公告)号：US20070020195A1

    公开(公告)日：2007-01-25

    申请号：US11449418

    申请日：2006-06-08

    申请人： Frank Greenway ,  Michael Cowley ,  Linda Young

    发明人： Frank Greenway ,  Michael Cowley ,  Linda Young

    IPC分类号： A61L9/04 ,  A61K31/522 ,  A61K31/4745 ,  A61K31/4166 ,  A61K31/165 ,  A61K31/137

    CPC分类号： A61K31/137 ,  A61K31/165 ,  A61K31/4166 ,  A61K31/4745 ,  A61K31/522 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods are described for suppressing appetite through the intranasal administration of a sodium channel blocker. It has long been known that smell and taste are an important part of how the body prepares for a meal, for example the cephalic phase of insulin release before a meal. Depressing the sense of smell or taste in subjects prior to meals leads to decreased food intake, which ultimately leads to weight loss. The ability to deliver drugs to the CSF via intranasal application also provides anorexiant central effect.

    摘要翻译： 描述了通过鼻内施用钠通道阻断剂来抑制食欲的方法。 长期以来人们已经知道，嗅觉和味道是身体如何准备饭菜的重要部分，例如饭前胰岛素释放的头部相位。 在饭前沮丧的受试者的嗅觉或味觉会导致食物摄取减少，最终导致体重下降。 通过鼻内应用将药物递送到CSF的能力也提供了厌氧中心作用。

    COMPOSITIONS COMPRISING TERPENE COMPOUNDS FOR TREATING NEGATIVE SENSORY PHENOMENA
    8.
    发明申请
    COMPOSITIONS COMPRISING TERPENE COMPOUNDS FOR TREATING NEGATIVE SENSORY PHENOMENA 审中-公开
    包含化合物的组合物用于处理负离子传感器

    公开(公告)号：US20160317466A1

    公开(公告)日：2016-11-03

    申请号：US15207704

    申请日：2016-07-12

    申请人： Alexander McLellan ,  Frank Greenway

    发明人： Alexander McLellan ,  Frank Greenway

    IPC分类号： A61K31/045 ,  A61K9/00

    CPC分类号： A61K31/045 ,  A61K9/0014 ,  A61K31/121 ,  A61K31/122 ,  A61K31/22 ,  A61K31/351

    摘要： Compositions comprising terpene compounds for the treatment of negative sensory phenomena (NSP). Negative sensory phenomena is characterized by a decreased ability to sense light touch, pin prick, vibration, temperature, pain and/or reduced proprioception. The terpene compounds are preferably aromatic terpene compounds such as geraniol and citronellol and analogs thereof. The terpenes may also be used in combination. The terpenes are derived form plant essential oils or are manufactured synthetically.

    摘要翻译： 包含用于治疗阴性感觉现象（NSP）的萜烯化合物的组合物。 负感觉现象的特征在于感测轻触感，针刺，振动，温度，疼痛和/或减少本体感觉的能力下降。 萜烯化合物优选为芳族萜烯化合物，例如香叶醇和香茅醇及其类似物。 萜烯也可以组合使用。 萜烯衍生自植物精油或合成制成。

    COMPOSITION AND METHOD FOR INHIBITION OF NERVE TRANSMISSION
    10.
    发明申请
    COMPOSITION AND METHOD FOR INHIBITION OF NERVE TRANSMISSION 有权
    用于抑制神经传递的组合物和方法

    公开(公告)号：US20110257255A1

    公开(公告)日：2011-10-20

    申请号：US12537095

    申请日：2009-08-06

    申请人： Alexander McLellan ,  Frank Greenway

    发明人： Alexander McLellan ,  Frank Greenway

    IPC分类号： A61K31/045 ,  A61P25/00 ,  A61K31/22 ,  A61K31/122 ,  A61K31/351 ,  A61K31/11

    CPC分类号： A61K31/045 ,  A61K31/121 ,  A61K31/122 ,  A61K31/22 ,  A61K31/351 ,  A61K36/185

    摘要： The presently claimed and disclosed invention(s) provides a therapeutically effective composition and method of inhibiting nerve cell transmission. In a preferred embodiment of the presently claimed and disclosed invention(s), the treatment of neuropathic pain utilizing terpene compounds isolated from plant essential oils or manufactured synthetically is detailed. These compounds, such as geraniol and citronellol, as well as chemical analogs thereof, used in combination or individually, can be used alone or in a composition with a pharmaceutically acceptable carrier in a suitable dosage form.

    摘要翻译： 本发明的权利要求和公开的发明提供了抑制神经细胞传播的治疗有效的组合物和方法。 在本发明权利要求和公开的发明的优选实施方案中，使用从植物精油中分离或合成制备的萜烯化合物治疗神经性疼痛是详细的。 这些化合物，如香叶醇和香茅醇，以及其组合或单独使用的化学类似物，可以单独使用或与药学上可接受的载体以合适的剂型组合使用。