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    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
    2.
    发明申请
    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof 审中-公开
    双环杂环，含有这些化合物的药物组合物，其用途及其制备方法

    公开(公告)号：US20110136806A1

    公开(公告)日：2011-06-09

    申请号：US13027669

    申请日：2011-02-15

    申请人： Frank HIMMELSBACH ,  Birgit JUNG

    发明人： Frank HIMMELSBACH ,  Birgit JUNG

    IPC分类号： A61K31/5377 ,  C07D401/12 ,  C07D413/14 ,  C07D239/94 ,  A61K31/517 ,  A61P1/00 ,  A61P35/00 ,  A61P11/00

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

    摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re and X are as defined in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, in particular, the physiologically-acceptable salts thereof with inorganic and organic acids with useful pharmacological properties, in particular, an inhibitory effect on signal transduction brought about by tyrosine kinases, the use thereof for the treatment of diseases, in particular of tumour diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and airways and production thereof.

    摘要翻译： 本发明涉及通式（I）的双环杂环，其中Ra，Rb，Rc，Rd，Re和X如权利要求1所定义，互变异构体，立体异构体，其混合物和盐，特别是生理上可接受的 其与具有有用药理学性质的无机和有机酸的盐，特别是对由酪氨酸激酶引起的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生症（BPH），疾病 的肺和气道及其生产。

    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production
    3.
    发明申请
    Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production 有权
    含有所述化合物的螺环杂环药物及其制备方法及其制备方法

    公开(公告)号：US20130281461A1

    公开(公告)日：2013-10-24

    申请号：US13920389

    申请日：2013-06-18

    申请人： Frank HIMMELSBACH ,  Birgit JUNG ,  Ralf LOTZ

    发明人： Frank HIMMELSBACH ,  Birgit JUNG ,  Ralf LOTZ

    IPC分类号： C07D403/12

    CPC分类号： C07D403/12

    摘要： The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式（I）的互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐的螺环杂环，其具有有价值的药理学性质，特别是对 由酪氨酸激酶介导的信号转导，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途及其制备。

    QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    4.
    发明申请
    QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
    喹诺酮衍生物和含有它们的药物组合物

    公开(公告)号：US20100010023A1

    公开(公告)日：2010-01-14

    申请号：US12563340

    申请日：2009-09-21

    申请人： Frank HIMMELSBACH ,  Elke LANGKOPF ,  Stefan BLECH ,  Birgit JUNG ,  Anke BAUM ,  Flavio SOLCA

    发明人： Frank HIMMELSBACH ,  Elke LANGKOPF ,  Stefan BLECH ,  Birgit JUNG ,  Anke BAUM ,  Flavio SOLCA

    IPC分类号： A61K31/517 ,  C07D239/94 ,  C07D413/02 ,  C07D405/02 ,  A61P35/00

    CPC分类号： C07D405/12 ,  C07D239/94

    摘要： A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group; Rb is a dimethylamino, N-methyl-N-ethylamino, diethylamino, N-methyl-N-isopropylamino, N-methyl-N-cyclopropylamino, N-methyl-N-(2-methoxyethyl)amino, N-ethyl-N-(2-methoxyethyl)amino, bis(2-methoxyethyl)amino, morpholino, N-methyl-N-(tetra-hydrofuran-3-yl)amino, N-methyl-N-(tetrahydrofuran-2-ylmethyl)amino, N-methyl-N-(tetra-hydrofuran-3-ylmethyl)amino, N-methyl-N-(tetrahydropyran-4-yl)amino, or N-methyl-N-(tetrahydropyran-4-ylmethyl)amino group; and Rc is a cyclopropylmethoxy, cyclobutyloxy, cyclopentyloxy, tetrahydrofuran-3-yloxy, tetrahydrofuran-2-ylmethoxy, tetrahydrofuran-3-ylmethoxy, tetrahydropyran-4-yloxy, or tetrahydropyran-4-ylmethoxy group, or a tautomer, stereoisomer, or salt thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 通式I的化合物，其中：R a是苄基，1-苯乙基或3-氯-4-氟苯基; Rb是二甲基氨基，N-甲基-N-乙基氨基，二乙基氨基，N-甲基-N-异丙基氨基，N-甲基-N-环丙基氨基，N-甲基-N-（2-甲氧基乙基）氨基，N-乙基-N- （2-甲氧基乙基）氨基，双（2-甲氧基乙基）氨基，吗啉代，N-甲基-N-（四氢呋喃-3-基）氨基，N-甲基-N-（四氢呋喃-2-基甲基）氨基，N - 甲基-N-（四氢呋喃-3-基甲基）氨基，N-甲基-N-（四氢吡喃-4-基）氨基或N-甲基-N-（四氢吡喃-4-基甲基）氨基; Rc为环丙基甲氧基，环丁氧基，环戊氧基，四氢呋喃-3-基氧基，四氢呋喃-2-基甲氧基，四氢呋喃-3-基甲氧基，四氢吡喃-4-基氧基或四氢吡喃-4-基甲氧基，或互变异构体，立体异构体或盐 特别是其具有有价值的药理学特性的无机或有机酸或碱的生理上可接受的盐，特别是对由酪氨酸激酶介导的信号转导的抑制作用，它们在治疗疾病尤其是肿瘤疾病和肺疾病中的用途 和气道及其制备。

    METHODS OF TREATING DISEASES USING QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    7.
    发明申请
    METHODS OF TREATING DISEASES USING QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
    使用喹唑啉衍生物和含有它们的药物组合物治疗疾病的方法

    公开(公告)号：US20110046168A1

    公开(公告)日：2011-02-24

    申请号：US12914003

    申请日：2010-10-28

    申请人： Frank HIMMELSBACH ,  Elke LANGKOPF ,  Stefan BLECH ,  Birgit JUNG ,  Anke BAUM ,  Flavio SOLCA

    发明人： Frank HIMMELSBACH ,  Elke LANGKOPF ,  Stefan BLECH ,  Birgit JUNG ,  Anke BAUM ,  Flavio SOLCA

    IPC分类号： A61K31/517 ,  A61P35/00 ,  A61P1/00 ,  A61P11/00 ,  A61P17/06

    CPC分类号： C07D405/12 ,  C07D239/94

    摘要： A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group; Rb is a dimethylamino, N-methyl-N-ethylamino, diethylamino, N-methyl-N-isopropylamino, N-methyl-N-cyclopropylamino, N-methyl-N-(2-methoxyethyl)amino, N-ethyl-N-(2-methoxyethyl)amino, bis(2-methoxyethyl)amino, morpholino, N-methyl-N-(tetrahydrofuran-3-yl)amino, N-methyl-N-(tetrahydrofuran-2-ylmethyl)amino, N-methyl-N-(tetrahydrofuran-3-ylmethyl)amino, N-methyl-N-(tetrahydropyran-4-yl)amino, or N-methyl-N-(tetrahydropyran-4-ylmethyl)amino group; and Rc is a cyclopropylmethoxy, cyclobutyloxy, cyclopentyloxy, tetrahydrofuran-3-yloxy, tetrahydrofuran-2-ylmethoxy, tetrahydrofuran-3-ylmethoxy, tetrahydropyran-4-yloxy, or tetrahydropyran-4-ylmethoxy group, or a tautomer, stereoisomer, or salt thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.

    摘要翻译： 通式I的化合物，其中：R a是苄基，1-苯乙基或3-氯-4-氟苯基; Rb是二甲基氨基，N-甲基-N-乙基氨基，二乙基氨基，N-甲基-N-异丙基氨基，N-甲基-N-环丙基氨基，N-甲基-N-（2-甲氧基乙基）氨基，N-乙基-N- （2-甲氧基乙基）氨基，双（2-甲氧基乙基）氨基，吗啉代，N-甲基-N-（四氢呋喃-3-基）氨基，N-甲基-N-（四氢呋喃-2-基甲基）氨基，N-甲基 -N-（四氢呋喃-3-基甲基）氨基，N-甲基-N-（四氢吡喃-4-基）氨基或N-甲基-N-（四氢吡喃-4-基甲基）氨基; Rc为环丙基甲氧基，环丁氧基，环戊氧基，四氢呋喃-3-基氧基，四氢呋喃-2-基甲氧基，四氢呋喃-3-基甲氧基，四氢吡喃-4-基氧基或四氢吡喃-4-基甲氧基，或互变异构体，立体异构体或盐 特别是其具有有价值的药理学特性的无机或有机酸或碱的生理上可接受的盐，特别是对由酪氨酸激酶介导的信号转导的抑制作用，它们在治疗疾病尤其是肿瘤疾病和肺疾病中的用途 和气道及其制备。