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公开(公告)号：US06764697B1
公开(公告)日：2004-07-20
申请号：US09023574
申请日：1998-02-13
IPC分类号： A61K922
CPC分类号： A61K9/0004 , A61K31/275 , A61K31/277 , A61K31/401 , A61K31/4422 , A61K31/554 , A61K38/556
摘要： A dosage form is disclosed comprising means for delaying the delivery of drug from the dosage form following the administration of the dosage form to a patient in need of drug therapy.
摘要翻译： 公开了一种剂型，其包括在将剂型施用给需要药物治疗的患者之后延迟药物从剂型递送的方法。
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公开(公告)号：US5955103A
公开(公告)日：1999-09-21
申请号：US871748
申请日：1997-06-09
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K47/34
CPC分类号： A61K31/00 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K9/0004 , Y10S514/964
摘要： A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
摘要翻译： 公开了用于递送抗癫痫药物的剂型，该剂型包括用于维持剂型和抗癫痫药物的完整性的层压壁。
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公开(公告)号：US06342249B1
公开(公告)日：2002-01-29
申请号：US09470088
申请日：1999-12-22
IPC分类号： A61K922
CPC分类号： A61K9/0065 , A61K9/0004 , A61K9/1075 , A61K9/1611 , A61K9/1617 , A61K9/2009 , A61K9/2072 , A61K9/2095 , A61K9/501
摘要： Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
摘要翻译： 通过将含有液体活性剂制剂的多孔颗粒分散在渗透的推层剂型中来提供液体，活性剂制剂的控制释放。 剂型可以提供活性剂的连续或脉动递送。
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4.发明授权公开(公告)号：US06419952B2
公开(公告)日：2002-07-16
申请号：US09866036
申请日：2001-05-25
IPC分类号： A61K948
CPC分类号： A61K9/0004
摘要： A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.
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公开(公告)号：US06595951B1
公开(公告)日：2003-07-22
申请号：US09575074
申请日：2000-05-19
申请人： Patrick S. -L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
发明人： Patrick S. -L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
IPC分类号： A61M3700
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及用于口服活性剂递送装置的封闭系统。 该装置包括具有第一端和第二端的细长管状构件。 闭合系统包括适于允许活化剂在变形时输送的可变形闭合装置。 闭合系统防止溢出并维持装置内剂量的完整性。 在使用中，封闭系统变形并与管状构件的第二端分离，液体被拉入构件的第一端，并且液体和活性剂从构件的第二端被拉出并进入 病人的嘴。
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公开(公告)号：US06797283B1
公开(公告)日：2004-09-28
申请号：US09469399
申请日：1999-12-22
IPC分类号： A61K924
CPC分类号： A61K9/0065 , Y10S424/06 , Y10S514/836 , Y10S514/866 , Y10S514/884 , Y10S514/909 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use. The active agent dosage form is a multilayer core, often bilayer, formed of polymer matrices that swell upon contact with the fluids of the stomach. At least one layer of the multilayered dosage form includes an active agent. A portion of the polymer matrices are surrounded by a band of insoluble material that prevents the covered portion of the polymer matrices from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
摘要翻译： 本发明涉及一种多层剂型，其适于保留在胃中并且可用于将活性剂延长递送至使用的流体环境。 活性剂剂型是由与胃液接触时膨胀的聚合物基质形成的多层芯，通常是双层的。 至少一层多层剂型包括活性剂。 聚合物基质的一部分被不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并且提供具有足够刚度以抵抗胃收缩和延迟排出 剂型，直到基本上所有的活性剂已被分配。
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公开(公告)号：US5830501A
公开(公告)日：1998-11-03
申请号：US964548
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US06596314B2
公开(公告)日：2003-07-22
申请号：US10022300
申请日：2001-12-14
IPC分类号： A61K922
CPC分类号： A61K9/0065 , A61K9/0004 , A61K9/1075 , A61K9/1611 , A61K9/1617 , A61K9/2009 , A61K9/2072 , A61K9/2095 , A61K9/501
摘要： Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
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公开(公告)号：US6106845A
公开(公告)日：2000-08-22
申请号：US299740
申请日：1999-04-27
CPC分类号： A61K9/0092 , A47G21/183 , A61J7/0038
摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.
摘要翻译： 本发明涉及一种用于将活性剂制剂的离散单元递送至患者的口服活性剂递送系统和方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持剂的活性剂制剂室在第一端置于流体中，并在第二端置于患者口中。 当患者在房间的第二端上浸泡时，递送活性剂。
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公开(公告)号：US5698224A
公开(公告)日：1997-12-16
申请号：US266045
申请日：1994-06-27
申请人： George V. Guittard , Jerry D. Childers , Patrick S. -L. Wong , Fernando E. Gumucio , David J. Kidney
发明人： George V. Guittard , Jerry D. Childers , Patrick S. -L. Wong , Fernando E. Gumucio , David J. Kidney
CPC分类号： A61K31/00 , A61K45/06 , A61K9/0004 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： A dosage form is disclosed for administering 10 ng to 1200 mg tacrine to a patient in need of tacrine therapy.
摘要翻译： 公开了给需要他克林治疗的患者施用10ng至1200mg他克林的剂型。
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