公开(公告)号：US20060035270A1

公开(公告)日：2006-02-16

申请号：US11249847

申请日：2005-10-13

申请人： Frank Lee ,  Xun Meng ,  John Chan ,  Shengsheng Zhang ,  Stephen Benkovic

发明人： Frank Lee ,  Xun Meng ,  John Chan ,  Shengsheng Zhang ,  Stephen Benkovic

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00

CPC分类号： C40B30/04 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C12Q1/48 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6842 ,  G01N33/6851 ,  Y02A90/26

摘要： Disclosed are methods for reliably detecting the presence of proteins in a sample by the use of capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins in the sample. Arrays comprising these capture agents are also provided.

摘要翻译： 公开的是通过使用识别和与样品中一组蛋白质唯一特征的识别序列相互作用的捕获剂来可靠地检测样品中蛋白质的存在的方法。 还提供了包含这些捕获剂的阵列。

公开(公告)号：US20060014212A1

公开(公告)日：2006-01-19

申请号：US11066967

申请日：2005-02-25

申请人： Stephen Benkovic ,  John Chan ,  Frank Lee ,  Xun Meng ,  Neal Gordon

发明人： Stephen Benkovic ,  John Chan ,  Frank Lee ,  Xun Meng ,  Neal Gordon

IPC分类号： G01N33/53 ,  G06F19/00

CPC分类号： B82Y5/00 ,  B82Y10/00 ,  G01N33/6842 ,  G16B30/00

摘要： Disclosed are reagents and methods for reliably detecting the presence and measuring the amount of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.

摘要翻译： 公开了用于可靠地检测样品的存在和测量蛋白质的量的试剂和方法，所述蛋白质包括通过使用一种或多种捕获剂在样品中具有各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质， 识别和与样品中蛋白质或蛋白质组（蛋白质组表位标签或PET）的独特特征的识别序列相互作用。 还提供了包含这些捕获剂或PET的阵列。

公开(公告)号：US20060178862A1

公开(公告)日：2006-08-10

申请号：US11332837

申请日：2006-01-13

申请人： John Chan ,  John Schwartz ,  Joseph Jacobson ,  Frank Lee

发明人： John Chan ,  John Schwartz ,  Joseph Jacobson ,  Frank Lee

IPC分类号： G06G7/48 ,  G06G7/58

CPC分类号： G06F17/50

摘要： A preferred embodiment of the present invention comprises computer-implemented methods for providing user assistance in biomachine design that, first, retrieve one or more digitally-represented candidate design items stored in a bioengineering knowledge base by translating requirements provided for a biomachine according to a bioengineering domain model into queries to the knowledge base for design items capable of implementing the biomachine according to the domain model; then second, construct one or more digitally-represented candidate biomachines from the candidate design items by arranging part information represented in the candidate design items according to a selected structure, and next evaluate the candidate biomachines according to bioengineering operability knowledge associated with the candidate design items, wherein operability knowledge associated with a design item specifies requirements for that item to inter-operate with other design items. The methods may backtrack. If at least one candidate biomachine has not been satisfactorily evaluated, the methods backtracking to one or more of these steps. The invention further encompasses variations of these methods, systems and program products performing these methods, data products including digital representations of design knowledge used by these methods, data products with digital representations of designed biomachines. Also encompassed are further steps of constructing or synthesizing biomachines along with the actual biomachines themselves.

摘要翻译： 本发明的优选实施例包括用于在生物加工设计中提供用户帮助的计算机实现的方法，其首先通过根据生物工程翻译为生物加工提供的要求来检索存储在生物工程知识库中的一个或多个数字化表示的候选设计项目 领域模型，根据领域模型，对能够实现生物加工的设计项目的知识库进行查询; 然后第二，通过根据所选择的结构布置在候选设计项目中表示的部分信息，从候选设计项目构建一个或多个数字化表示的候选生物加工，然后根据与候选设计项目相关联的生物工程可操作性知识来评估候选生物加工 其中与设计项目相关联的操作性知识指定该项目与其他设计项目进行互操作的要求。 方法可能会回溯。 如果至少一个候选生物加工未得到令人满意的评估，则该方法回溯到一个或多个这些步骤。 本发明还包括执行这些方法的这些方法，系统和程序产品的变体，包括由这些方法使用的设计知识的数字表示的数据产品，具有设计的生物加工的数字表示的数据产品。 还包括构建或合成生物加工以及实际生物加工本身的进一步步骤。

公开(公告)号：US20230349414A1

公开(公告)日：2023-11-02

申请号：US18220663

申请日：2023-07-11

申请人： John Chan ,  Rong Chen

发明人： John Chan ,  Rong Chen

IPC分类号： F16B39/282 ,  F16B39/24 ,  F16B35/04

CPC分类号： F16B39/282 ,  F16B39/24 ,  F16B35/041

摘要： An anti-loosening fastener includes a bolt including a head and a screw tail, a first washer configured to fit around the screw tail of the bolt, a first nut configured to screw onto the screw tail of the bolt, a second nut configured to screw onto the screw tail of the bolt, a first cutting surface located on the screw tail of the bolt. A first surface of the first washer includes one or more wedge-shaped helical teeth, and a first surface of the first nut includes one or more wedge-shaped helical teeth. The bolt, the first washer, the first nut, the second nut, and the cutting surface are capable of affixing a component. The anti-loosening fastener may also include a second cutting surface located on the screw tail of the bolt.

公开(公告)号：US20080006549A1

公开(公告)日：2008-01-10

申请号：US11825981

申请日：2007-07-09

申请人： John Chan

发明人： John Chan

IPC分类号： A61C17/22

CPC分类号： A61C17/225 ,  A61C17/22 ,  A61C17/221 ,  A61C2202/00 ,  H01H9/06 ,  H01H15/102 ,  H01H25/00

摘要： An actuator assembly and packaging feature for an electric toothbrush is disclosed. The actuator assembly includes a positionable member accessible along the outer surface of the toothbrush body. The actuator assembly further includes a spring member retained within the interior of the toothbrush body which urges a cam member against the underside of the positionable member. The positionable member defines an aperture extending through its midsection within which is disposed a depressible member. The depressible member has an outer end which is also accessible along the outer surface of the toothbrush body. Upon pressing the depressible member, the cam member and spring are urged against an electrical circuit provided within the body of the toothbrush which is used to selectively operate a motor and drive mechanism to move one or more sets of bristles. The actuator assembly additionally includes a feature of providing a raised region along an outer surface of the positionable member which guards against accidental or unintentional depressing of the depressible member. The packaging feature relates to a member formed in a package cover that is suitably sized and positioned over the depressible member of the actuator so that the cover, when pressed, may momentarily activate the toothbrush within the package.

摘要翻译： 公开了一种用于电动牙刷的致动器组件和包装特征。 致动器组件包括可沿着牙刷本体的外表面接近的可定位构件。 致动器组件还包括保持在牙刷本体内部的弹簧构件，其将凸轮构件推压抵靠可定位构件的下侧。 可定位构件限定延伸穿过其中部的孔，在其中设置有可压下的构件。 可压下的构件具有外端，其也可以沿着牙刷本体的外表面接近。 在按压可按压的构件时，凸轮构件和弹簧被推靠在设置在牙刷主体内的电路，该电路用于选择性地操作马达和驱动机构以移动一组或多组刷毛。 致动器组件还包括沿着可定位构件的外表面提供凸起区域的特征，其防止可压下构件的意外或无意的压下。 包装特征涉及形成在包装盖中的构件，其被适当地定尺寸并且被定位在致动器的可压下构件上方，使得盖被按压时可以暂时激活包装内的牙刷。

公开(公告)号：US20060257822A1

公开(公告)日：2006-11-16

申请号：US11488204

申请日：2006-07-18

申请人： Chanchal Ghosh ,  Satyanarayana Majeti ,  Aleksey Pinyayev ,  John Chan ,  Alan Willey

发明人： Chanchal Ghosh ,  Satyanarayana Majeti ,  Aleksey Pinyayev ,  John Chan ,  Alan Willey

IPC分类号： A61C5/00

CPC分类号： A61C17/222 ,  A46B15/0002 ,  A46B15/0036 ,  A46B2200/1066 ,  A61C1/088 ,  A61C17/22 ,  A61C17/3436 ,  A61C17/349 ,  A61C19/063 ,  A61C19/066 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0651 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/49113 ,  H01L2924/00014

摘要： Disclosed is a method for providing an oral care benefit by combining the use of an oral care composition with an electric toothbrush having an electrically powered element disposed thereon. In particular methods are described for using an electric toothbrush comprising a light emitting element, with oral care compositions to provide tooth whitening and stain removal.

摘要翻译： 公开了一种通过组合使用口腔护理组合物与其上设置有电力元件的电动牙刷来提供口腔护理益处的方法。 具体描述了使用包括发光元件的电动牙刷和口腔护理组合物来提供牙齿增白和去污的方法。

公开(公告)号：US20060117505A1

公开(公告)日：2006-06-08

申请号：US11295907

申请日：2005-12-07

申请人： John Chan

发明人： John Chan

IPC分类号： A61C17/22

CPC分类号： A61C17/3472 ,  A61C17/349

摘要： An electric toothbrush is provided. The electric toothbrush has a handle, a head with a carriers and a longitudinal axis, and a neck disposed between the handle and the head. A motor is disposed within the handle. A shaft is operatively connected to the motor. The shaft is operatively connected to the carrier to move the carrier in a first motion. The carrier is capable of moving in a second motion when subjected to user forces.

摘要翻译： 提供电动牙刷。 电动牙刷具有手柄，具有托架和纵向轴线的头部以及设置在手柄和头部之间的颈部。 电机设置在手柄内。 轴可操作地连接到电动机。 轴可操作地连接到载体以在第一运动中移动载体。 当受到使用者的力量时，载体能够以第二动作移动。

公开(公告)号：US20060048315A1

公开(公告)日：2006-03-09

申请号：US11220219

申请日：2005-09-06

申请人： John Chan ,  Douglas Gall

发明人： John Chan ,  Douglas Gall

IPC分类号： A61C17/22

CPC分类号： A61C17/349 ,  A61C17/3436 ,  A61C17/3454

摘要： An electric toothbrush is provided. The electric toothbrush has a handle, a head with first and second bristle holders and a longitudinal axis, and a neck disposed between the handle and the head. A motor is disposed within the handle. A shaft is operatively connected to the motor. The shaft pivots in a side-to-side direction and is operatively connected to the first and second bristle holders to move the second bristle holder in a side-to-side direction and to oscillate the first bristle holder about an axis generally perpendicular to the longitudinal axis of the head.

摘要翻译： 提供电动牙刷。 电动牙刷具有手柄，头部具有第一和第二刷毛保持器和纵向轴线，以及设置在手柄和头部之间的颈部。 电机设置在手柄内。 轴可操作地连接到电动机。 轴以一个侧向方向枢转并且可操作地连接到第一和第二刷毛保持器以使第二刷毛支架沿着侧向方向移动，并使第一刷毛支架围绕大致垂直于 头部纵轴。

公开(公告)号：US20050273952A1

公开(公告)日：2005-12-15

申请号：US11206542

申请日：2005-08-18

申请人： John Chan ,  Wang Ping

发明人： John Chan ,  Wang Ping

IPC分类号： A46B9/04 ,  A46B13/02 ,  A61C17/22 ,  A61C17/34

CPC分类号： A46B9/04 ,  A46B13/02 ,  A46B15/0032 ,  A61C17/222 ,  A61C17/3436 ,  A61C17/3445 ,  A61C17/349

摘要： An electric toothbrush is provided. The electric toothbrush has an elongate body having a handle, a head, and a neck extending between the handle and the head. The body has an interior chamber with a motor. A shaft is operatively connected to the motor. A first movable bristle carrier is disposed on the head. The shaft is operatively connected to the first bristle carrier to impart motion thereto. The first bristle carrier has a first composite tuft formed from a plurality of closely spaced bristle tufts and a plurality of second bristle tufts. The second tufts have a height that is greater than a height of the first composite tuft. The bristles of the first composite tuft having free ends and the bristles of the second tufts having free ends. The total surface area of the bristles of the first composite tuft is greater than the total surface area of the bristles of the second tufts, and the plurality of second tufts are disposed adjacent a portion of a perimeter of the composite tuft to form a first recessed region.

摘要翻译： 提供电动牙刷。 电动牙刷具有细长主体，其具有手柄，头部和在手柄和头部之间延伸的颈部。 车身有一个带有马达的内室。 轴可操作地连接到电动机。 第一可移动的刷毛载体设置在头部上。 轴可操作地连接到第一刷毛载体以赋予其运动。 第一刷毛载体具有由多个紧密间隔的刷毛簇和多个第二刷毛簇形成的第一复合刷毛簇。 第二簇具有大于第一复合簇的高度的高度。 具有自由端的第一复合簇的刷毛和具有自由端的第二簇的刷毛。 第一复合毛簇的刷毛的总表面积大于第二毛簇的刷毛的总表面积，并且多个第二毛簇邻近复合毛簇的周边的一部分设置，以形成第一凹陷 地区。

公开(公告)号：US20050066459A1

公开(公告)日：2005-03-31

申请号：US10887644

申请日：2004-07-09

申请人： Aleksey Pinyayev ,  John Chan

发明人： Aleksey Pinyayev ,  John Chan

IPC分类号： A61C17/22 ,  A61C17/26 ,  A61C17/34 ,  A61C19/06 ,  A61N5/06

CPC分类号： A61C17/34 ,  A61C17/22 ,  A61C17/26 ,  A61C19/063 ,  A61C19/066 ,  A61N2005/0651

摘要： Disclosed is an electric toothbrush having an electrically powered element disposed on the head, and at least one removable and replaceable component. In particular is disclosed an electric toothbrush having removable and replaceable bristle holder, which can be removed and replaced without removing the electrically powered element from the head of the toothbrush.

摘要翻译： 公开了一种电动牙刷，其具有设置在头部上的电动元件，以及至少一个可拆卸和可更换部件。 具体地，公开了一种具有可移除和可替换的刷毛支架的电动牙刷，其可以被移除和更换，而不从牙刷的头部移除电动元件。