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    2-Cyano indan-1,3-diones
    2.
    发明授权
    2-Cyano indan-1,3-diones 失效
    2-氰基茚满-1,3-二酮

    公开(公告)号：US4012407A

    公开(公告)日：1977-03-15

    申请号：US572226

    申请日：1975-04-28

    申请人： Frank Peter Doyle ,  Barrie Christian Charles Cantello ,  Derek Richard Buckle ,  Harry Smith

    发明人： Frank Peter Doyle ,  Barrie Christian Charles Cantello ,  Derek Richard Buckle ,  Harry Smith

    IPC分类号： C07C49/67 ,  C07C255/45 ,  C07D307/56 ,  C07D311/42 ,  C07C121/75 ,  C07C121/76

    CPC分类号： C07C247/00 ,  C07C49/67 ,  C07C2103/16

    摘要： Pharmaceutical compositions are produced comprising as the active ingredient a compound of the formula ##STR1## or a pharmaceutically acceptable, nontoxic salt thereof or hydrate thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is a bond or an oxygen atom, is combined with a pharmaceutically acceptable, nontoxic inert diluent or carrier. Those compounds wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all simultaneously hydrogen are novel.When X is a bond, the compounds may be prepared by reacting an appropriately substituted 3-dyanomethylene phthalide with a base and, thereafter, if desired, converting the compound to a salt. When X is an oxygen atom, the compounds may be prepared by reacting a suitably substituted benzene derivative with an activated carbonyl group having a carbanion of the formula NC--CH--R, wherein R is a carboxylic acid ester group, and thereafter, if desired, converting the compound into a salt.

    摘要翻译： 制备药物组合物，其包含作为活性成分的式IMA化合物或其药学上可接受的无毒盐或其水合物，其中R 1，R 2，R 3和R 4各自为氢，卤素，低级烷基或低级烷氧基，或 R 1，R 2，R 3和R 4中的任何两个与它们连接的碳原子一起形成取代或未取代的碳环，并且X是键或氧原子与药学上可接受的无毒的 惰性稀释剂或载体。 其中R1，R2，R3和R4不全部同时为氢的那些化合物是新的。