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公开(公告)号:US20110165230A1
公开(公告)日:2011-07-07
申请号:US13048412
申请日:2011-03-15
申请人: Franz Xaver HEINZ , Christian MANDL
发明人: Franz Xaver HEINZ , Christian MANDL
IPC分类号: A61K39/12 , A61K39/29 , A61K9/127 , A61K9/14 , A61P31/14 , A61P37/04 , A61P31/00 , C12N7/04 , C07H21/00
CPC分类号: C07K14/005 , A61K35/13 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161
摘要: Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterised in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
摘要翻译: 公开了一种包含黄病毒突变体的减毒黄病毒活疫苗,其特征在于黄病毒突变体在衣壳蛋白中具有至少大于4个连续氨基酸的缺失,其中羧基末端疏水区不受缺失影响。