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1.发明公开公开(公告)号：US20240226257A9
公开(公告)日：2024-07-11
申请号：US18492705
申请日：2023-10-23
发明人： Justin J. Taylor , Denise Galloway , Paul Nghiem , David Koelle , Haroldo Rodriguez , Joseph Carter
IPC分类号： A61K39/00 , A61K45/06 , A61P35/00 , C07K16/28 , G01N33/533 , G01N33/574
CPC分类号： A61K39/001111 , A61K45/06 , A61P35/00 , C07K16/2809 , G01N33/533 , G01N33/57492 , A61K2039/53 , G01N2333/7051
摘要： Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses. Related diagnostics are also described
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公开(公告)号：US20240150444A1
公开(公告)日：2024-05-09
申请号：US18548017
申请日：2022-02-25
CPC分类号： C07K16/1027 , A61P31/12 , A61K38/00 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Antibodies that protect against respiratory viral infections including human parainfluenza viruses (HPIV), respiratory syncytial virus (RSV), and human metapneumovirus (HMPV) are described. Certain antibodies disclosed herein neutralize more than one virus (e.g., RSV and HMPV). The binding fragments of the antibodies can be engineered into numerous formats including those that provide simultaneous protection against multiple viruses.
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公开(公告)号：US20240052013A1
公开(公告)日：2024-02-15
申请号：US18264749
申请日：2022-02-08
发明人： Justin J. Taylor , Laila Shehata , Marti Tooley
IPC分类号： C07K14/705 , C07K16/10 , C07K16/08 , C07K16/12 , C07K16/24 , C12N5/0781 , A61K39/00
CPC分类号： C07K14/70578 , C07K16/1027 , C07K16/10 , C07K16/1018 , C07K16/081 , C07K16/085 , C07K16/087 , C07K16/1282 , C07K16/241 , C07K14/70503 , C12N5/0635 , A61K39/4612 , A61K39/4622 , A61K39/4637 , C07K2319/03 , C07K2317/622 , C07K2319/02 , A61K2239/26 , A61K2239/22
摘要： Systems and methods to link CD40 signaling to antigen binding, independently of CD40 ligand binding are described. The systems and methods include fusion proteins including an extracellular antigen binding domain linked to an intracellular CD40 signaling domain.
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4.发明公开公开(公告)号：US20240131132A1
公开(公告)日：2024-04-25
申请号：US18492705
申请日：2023-10-22
发明人： Justin J. Taylor , Denise Galloway , Paul Nghiem , David Koelle , Haroldo Rodriguez , Joseph Carter
IPC分类号： A61K39/00 , A61K45/06 , A61P35/00 , C07K16/28 , G01N33/533 , G01N33/574
CPC分类号： A61K39/001111 , A61K45/06 , A61P35/00 , C07K16/2809 , G01N33/533 , G01N33/57492 , A61K2039/53 , G01N2333/7051
摘要： Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses. Related diagnostics are also described
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5.发明授权公开(公告)号：US11578118B2
公开(公告)日：2023-02-14
申请号：US16757707
申请日：2018-10-19
摘要： Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which no vaccinations are currently available; provide protection against infectious agents when patients are otherwise immune-suppressed; and/or provide a benefit provided by a therapeutic antibody, such as in the treatment of autoimmune disorders.
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6.发明公开公开(公告)号：US20230250159A1
公开(公告)日：2023-08-10
申请号：US18166151
申请日：2023-02-08
CPC分类号： C07K16/1027 , A61K35/17 , C07K16/082 , C07K16/085 , C07K16/087 , C07K16/088 , C07K16/1018 , C07K16/1045 , C07K16/1282 , C07K16/241 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2510/00 , C12N2750/14143 , C12N2800/80
摘要： Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which no vaccinations are currently available; provide protection against infectious agents when patients are otherwise immune-suppressed; and/or provide a benefit provided by a therapeutic antibody, such as in the treatment of autoimmune disorders.
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