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公开(公告)号:US20210155644A1
公开(公告)日:2021-05-27
申请号:US17158547
申请日:2021-01-26
Applicant: Fujifilm Corporation
Inventor: Hidenobu Kuniyoshi , Takehiro Yamane , Takayuki Yamakawa , Hideyasu Fujiwara , Eiichi Kodama
IPC: C07F9/6561 , A61P31/20 , C07F9/6574
Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides an anti-adenoviral agent including a compound represented by General Formula [1] (in the formula, R1 represents a hydrogen atom, a halogen atom, an amino group which may be substituted, a monocyclic nitrogen-containing heterocyclic ring group which may be substituted (provided that a nitrogen atom forming the ring is bonded to a carbon atom to which R1 is bonded), a monocyclic nitrogen- and oxygen-containing heterocyclic ring group which may be substituted (provided that a nitrogen atom forming the ring is bonded to a carbon atom to which R1 is bonded), a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; and X represents an oxygen atom or a sulfur atom) or a salt thereof.
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公开(公告)号:US12202850B2
公开(公告)日:2025-01-21
申请号:US18296151
申请日:2023-04-05
Applicant: FUJIFILM Corporation
Inventor: Hidenobu Kuniyoshi , Takehiro Yamane , Takayuki Yamakawa , Shintaro Tanabe , Hideyasu Fujiwara , Eiichi Kodama
IPC: A61K31/683 , A61P31/20 , C07F9/6561
Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.
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公开(公告)号:US09051310B2
公开(公告)日:2015-06-09
申请号:US14317001
申请日:2014-06-27
Applicant: FUJIFILM Corporation
Inventor: Hideyasu Fujiwara , Shinsuke Mizumoto , Yohei Kubo , Hiyoku Nakata , Shinji Hagiwara , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Tomoyuki Mashiko , Mari Yamamoto
IPC: C07D213/82 , C07D413/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D405/04
CPC classification number: C07D413/12 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.
Abstract translation: 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 根据本发明,提供由下式(I)表示的烟酰胺衍生物或其盐,其中R 1为下式(II-1),(III-1)或(IV- 1)(其中R3,R4,R5,n和X1具有与说明书中描述的相同的定义),R2是吡啶基,吲唑基,苯基,吡唑并吡啶基,苯并异恶唑基,嘧啶基或喹啉基, 具有至少一个取代基。
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公开(公告)号:US20230295202A1
公开(公告)日:2023-09-21
申请号:US18296151
申请日:2023-04-05
Applicant: FUJIFILM Corporation
Inventor: Hidenobu KUNIYOSHI , Takehiro Yamane , Takayuki Yamakawa , Shintaro Tanabe , Hideyasu Fujiwara , Eiichi Kodama
IPC: C07F9/6561 , A61K31/683 , A61P31/20
CPC classification number: C07F9/65616 , A61K31/683 , A61P31/20
Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1]
(in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.-
公开(公告)号:US20210147456A1
公开(公告)日:2021-05-20
申请号:US17158520
申请日:2021-01-26
Applicant: FUJIFILM Corporation
Inventor: Hidenobu KUNIYOSHI , Takehiro Yamane , Takayuki Yamakawa , Shintaro Tanabe , Hideyasu Fujiwara , Eiichi Kodama
IPC: C07F9/6561
Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.
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