摘要:
The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.
摘要:
Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.
摘要:
A benzoazine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group, carbamoyl group, acyl group, nitro group, carboxy group, or sulfonamide group; R.sup.2 and R.sup.3 may be the same or different and each individually represents a hydrogen atom or an alkyl group, or R.sup.2 and R.sup.3 indicate in combination an alkylene group having 2-7 carbon atoms; R.sup.4 and R.sup.5 may be the same or different and each individually represents a hydrogen atom or an alkyl group; X denotes O, S, or N--R.sup.6 (wherein R.sup.6 represents a hydrogen atom, an alkyl group, or an aryl group or pyridyl group which may have a substituent); m is an integer from 0 to 4; and n is an integer from 1 to 3, or a salt of the benzoazine derivative. The compound exhibits superior effects for reducing blood glucose value, plasma insulin value, and plasma triglyceride value, and is useful as a medicament for preventing or treating diabetes, hyperlipidemia, and obesity.
摘要翻译:由下式(1)表示的苯并嗪衍生物,其中R1表示烷基,烷氧基,卤素原子,卤代烷基,氨基,羟基,可具有取代基的苄氧基,氰基 ,氨基甲酰基,酰基,硝基,羧基或磺酰胺基; R2和R3可以相同或不同,各自独立地表示氢原子或烷基,或R2和R3组合表示具有2-7个碳原子的亚烷基; R 4和R 5可以相同或不同,各自独立地表示氢原子或烷基; X表示O,S或N-R6(其中R6表示氢原子,烷基或可具有取代基的芳基或吡啶基); m为0〜4的整数; n为1〜3的整数,或苯并嗪衍生物的盐。 该化合物对于降低血糖值,血浆胰岛素值和血浆甘油三酯值具有优异的效果,并且可用作预防或治疗糖尿病,高脂血症和肥胖症的药物。
摘要:
A quality improvement system using an FMEA table of the invention includes a defect data collecting unit to collect defect data about a defect in a manufacturing or inspection process and an FMEA table update unit to update the FMEA table online based on the data collected by the defect data collecting unit. The FMEA table includes a failure mode, the number of occurrences of the failure mode, and an effect caused by the failure mode. The FMEA table update unit includes an FMEA table editing unit to edit the FMEA table. The FMEA table editing unit edits the number of occurrences of the failure mode when a row including a set of an occurred failure mode and an effect corresponding to the occurred failure mode is previously defined in the FMEA table, and inserts the row into the FMEA table when the row is not defined in the FMEA table.
摘要:
A method of providing a program for a printed board packaging line is disclosed. A board packaging line coordinating computer downloads the service contract information and the application program contained in the contract information from an application server, and defines the board packaging line covered by the program and the device configuration of the line. The device configuration thus defined is uploaded to the application server, which, based on the device configuration thus uploaded, searches a prepared device driver group for a required device driver. This device driver is downloaded and set in each device by the board packaging line coordinating computer.
摘要:
A quality improvement system using an FMEA table of the invention includes a defect data collecting unit to collect defect data about a defect in a manufacturing or inspection process and an FMEA table update unit to update the FMEA table online based on the data collected by the defect data collecting unit. The FMEA table includes a failure mode, the number of occurrences of the failure mode, and an effect caused by the failure mode. The FMEA table update unit includes an FMEA table editing unit to edit the FMEA table. The FMEA table editing unit edits the number of occurrences of the failure mode when a row including a set of an occurred failure mode and an effect corresponding to the occurred failure mode is previously defined in the FMEA table, and inserts the row into the FMEA table when the row is not defined in the FMEA table.
摘要:
A method of providing a program for a printed board packaging line is disclosed. A board packaging line coordinating computer downloads the service contract information and the application program contained in the contract information from an application server, and defines the board packaging line covered by the program and the device configuration of the line. The device configuration thus defined is uploaded to the application server, which, based on the device configuration thus uploaded, searches a prepared device driver group for a required device driver. This device driver is downloaded and set in each device by the board packaging line coordinating computer.