Benzoazine derivative or salt thereof and pharmaceutical compostion
comprising the same
    1.
    发明授权
    Benzoazine derivative or salt thereof and pharmaceutical compostion comprising the same 失效
    苯并嗪衍生物或其盐和包含其的药物组合物

    公开(公告)号:US5710152A

    公开(公告)日:1998-01-20

    申请号:US791269

    申请日:1997-01-30

    CPC分类号: C07D417/12

    摘要: A benzoazine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group, carbamoyl group, acyl group, nitro group, carboxy group, or sulfonamide group; R.sup.2 and R.sup.3 may be the same or different and each individually represents a hydrogen atom or an alkyl group, or R.sup.2 and R.sup.3 indicate in combination an alkylene group having 2-7 carbon atoms; R.sup.4 and R.sup.5 may be the same or different and each individually represents a hydrogen atom or an alkyl group; X denotes O, S, or N--R.sup.6 (wherein R.sup.6 represents a hydrogen atom, an alkyl group, or an aryl group or pyridyl group which may have a substituent); m is an integer from 0 to 4; and n is an integer from 1 to 3, or a salt of the benzoazine derivative. The compound exhibits superior effects for reducing blood glucose value, plasma insulin value, and plasma triglyceride value, and is useful as a medicament for preventing or treating diabetes, hyperlipidemia, and obesity.

    摘要翻译: 由下式(1)表示的苯并嗪衍生物,其中R1表示烷基,烷氧基,卤素原子,卤代烷基,氨基,羟基,可具有取代基的苄氧基,氰基 ,氨基甲酰基,酰基,硝基,羧基或磺酰胺基; R2和R3可以相同或不同,各自独立地表示氢原子或烷基,或R2和R3组合表示具有2-7个碳原子的亚烷基; R 4和R 5可以相同或不同,各自独立地表示氢原子或烷基; X表示O,S或N-R6(其中R6表示氢原子,烷基或可具有取代基的芳基或吡啶基); m为0〜4的整数; n为1〜3的整数,或苯并嗪衍生物的盐。 该化合物对于降低血糖值,血浆胰岛素值和血浆甘油三酯值具有优异的效果,并且可用作预防或治疗糖尿病,高脂血症和肥胖症的药物。